NUB1 (negative regulator of ubiquitin like proteins 1)

2007-02-01  

Identity

HGNC
LOCATION
7q36.1
LOCUSID
ALIAS
BS4,NUB1L,NYREN18
FUSION GENES

Other Information

Locus ID:

NCBI: 51667
MIM: 607981
HGNC: 17623
Ensembl: ENSG00000013374

Variants:

dbSNP: 51667
ClinVar: 51667
TCGA: ENSG00000013374
COSMIC: NUB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000013374ENST00000413040H3BM14
ENSG00000013374ENST00000460712H7C5N1
ENSG00000013374ENST00000468404F8WDB6
ENSG00000013374ENST00000470229Q9Y5A7
ENSG00000013374ENST00000470316F8WDL9
ENSG00000013374ENST00000480714H7C5E1
ENSG00000013374ENST00000483358C9JRT6
ENSG00000013374ENST00000568733H3BM74

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
235250432013Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance.36
128169482003Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L.22
123747622002The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1.21
168773562006NUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1.20
224341922012FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis.19
167074962006The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10.15
153476462004The Leber congenital amaurosis protein AIPL1 modulates the nuclear translocation of NUB1 and suppresses inclusion formation by NUB1 fragments.11
229658772012NUB1 modulation of GSK3β reduces tau aggregation.9
262607932015NEDD8 Ultimate Buster 1 Long (NUB1L) Protein Suppresses Atypical Neddylation and Promotes the Proteasomal Degradation of Misfolded Proteins.9
150814062004Abolished interaction of NUB1 with mutant AIPL1 involved in Leber congenital amaurosis.8

Citation

Dessen P

NUB1 (negative regulator of ubiquitin like proteins 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43669/nub1