NUCB1 (nucleobindin 1)

2007-07-01  

Identity

HGNC
NUCB1
LOCATION
19q13.33
LOCUSID
4924
ALIAS
CALNUC,NUC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4924
MIM: 601323
HGNC: 8043
Ensembl: ENSG00000104805

Variants:

dbSNP: 4924
ClinVar: 4924
TCGA: ENSG00000104805
COSMIC: NUCB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104805ENST00000405315Q02818
ENSG00000104805ENST00000407032Q02818
ENSG00000104805ENST00000411700C9J3C1
ENSG00000104805ENST00000424608H7BZI1
ENSG00000104805ENST00000443560F8WB20
ENSG00000104805ENST00000451312C9JBD3
ENSG00000104805ENST00000452087C9JKZ2

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
216536972011G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs.27
176867662007Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation.21
173900152007Autoantibodies to Ca2+ binding protein Calnuc is a potential marker in colon cancer detection.12
196569462009A novel endoplasmic reticulum export signal: proline at the +2-position from the signal peptide cleavage site.12
152877312004Structural studies on the Ca2+-binding domain of human nucleobindin (calnuc).11
249953402014Decreased plasma nesfatin-1 level is related to the thyroid dysfunction in patients with type 2 diabetes mellitus.11
206793422010Nucleobindin 1 is a calcium-regulated guanine nucleotide dissociation inhibitor of G{alpha}i1.10
181547332008Modulation of nucleobindin-1 and nucleobindin-2 by caspases.8
225425272012Nucleobindin 1 caps human islet amyloid polypeptide protofibrils to prevent amyloid fibril formation.6
279971582017Chaperone-like Activity of Calnuc Prevents Amyloid Aggregation.3

Citation

Dessen P

NUCB1 (nucleobindin 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47594/nucb1