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NUCB2 (nucleobindin 2)

Identity

Alias_symbol (synonym)NEFA
Other aliasHEL-S-109
HGNC (Hugo) NUCB2
LocusID (NCBI) 4925
Atlas_Id 46341
Location 11p15.1  [Link to chromosome band 11p15]
Location_base_pair Starts at 17276718 and ends at 17331865 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CD46 (1q32.2) / NUCB2 (11p15.1)EIF4G2 (11p15.3) / NUCB2 (11p15.1)NUCB2 (11p15.1) / IMPA2 (18p11.21)
NUCB2 (11p15.1) / NUCB2 (11p15.1)NUCB2 (11p15.1) / PAK3 (Xq23)EIF4G2 11p15.3 / NUCB2 11p15.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NUCB2   8044
Cards
Entrez_Gene (NCBI)NUCB2  4925  nucleobindin 2
AliasesHEL-S-109; NEFA
GeneCards (Weizmann)NUCB2
Ensembl hg19 (Hinxton)ENSG00000070081 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000070081 [Gene_View]  chr11:17276718-17331865 [Contig_View]  NUCB2 [Vega]
ICGC DataPortalENSG00000070081
TCGA cBioPortalNUCB2
AceView (NCBI)NUCB2
Genatlas (Paris)NUCB2
WikiGenes4925
SOURCE (Princeton)NUCB2
Genetics Home Reference (NIH)NUCB2
Genomic and cartography
GoldenPath hg38 (UCSC)NUCB2  -     chr11:17276718-17331865 +  11p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NUCB2  -     11p15.1   [Description]    (hg19-Feb_2009)
EnsemblNUCB2 - 11p15.1 [CytoView hg19]  NUCB2 - 11p15.1 [CytoView hg38]
Mapping of homologs : NCBINUCB2 [Mapview hg19]  NUCB2 [Mapview hg38]
OMIM608020   
Gene and transcription
Genbank (Entrez)AB231311 AF052642 AF052643 AF052644 AF450266
RefSeq transcript (Entrez)NM_001330227 NM_005013
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NUCB2
Cluster EST : UnigeneHs.654599 [ NCBI ]
CGAP (NCI)Hs.654599
Alternative Splicing GalleryENSG00000070081
Gene ExpressionNUCB2 [ NCBI-GEO ]   NUCB2 [ EBI - ARRAY_EXPRESS ]   NUCB2 [ SEEK ]   NUCB2 [ MEM ]
Gene Expression Viewer (FireBrowse)NUCB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4925
GTEX Portal (Tissue expression)NUCB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP80303   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP80303  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP80303
Splice isoforms : SwissVarP80303
PhosPhoSitePlusP80303
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    NUCB2   
Domain families : Pfam (Sanger)EF-hand_7 (PF13499)   
Domain families : Pfam (NCBI)pfam13499   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)NUCB2
DMDM Disease mutations4925
Blocks (Seattle)NUCB2
SuperfamilyP80303
Human Protein AtlasENSG00000070081
Peptide AtlasP80303
HPRD09726
IPIIPI00009123   IPI00922708   IPI00979363   IPI00976039   IPI00983455   IPI00979165   IPI00978037   IPI00980065   IPI00982588   IPI00982023   IPI00977950   
Protein Interaction databases
DIP (DOE-UCLA)P80303
IntAct (EBI)P80303
FunCoupENSG00000070081
BioGRIDNUCB2
STRING (EMBL)NUCB2
ZODIACNUCB2
Ontologies - Pathways
QuickGOP80303
Ontology : AmiGODNA binding  calcium ion binding  protein binding  extracellular space  nuclear envelope  endoplasmic reticulum  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  cytosol  plasma membrane  extracellular exosome  
Ontology : EGO-EBIDNA binding  calcium ion binding  protein binding  extracellular space  nuclear envelope  endoplasmic reticulum  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  cytosol  plasma membrane  extracellular exosome  
NDEx NetworkNUCB2
Atlas of Cancer Signalling NetworkNUCB2
Wikipedia pathwaysNUCB2
Orthology - Evolution
OrthoDB4925
GeneTree (enSembl)ENSG00000070081
Phylogenetic Trees/Animal Genes : TreeFamNUCB2
HOVERGENP80303
HOGENOMP80303
Homologs : HomoloGeneNUCB2
Homology/Alignments : Family Browser (UCSC)NUCB2
Gene fusions - Rearrangements
Fusion : MitelmanEIF4G2/NUCB2 [11p15.3/11p15.1]  [t(11;11)(p15;p15)]  
Fusion: TCGAEIF4G2 11p15.3 NUCB2 11p15.1 THCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNUCB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NUCB2
dbVarNUCB2
ClinVarNUCB2
1000_GenomesNUCB2 
Exome Variant ServerNUCB2
ExAC (Exome Aggregation Consortium)NUCB2 (select the gene name)
Genetic variants : HAPMAP4925
Genomic Variants (DGV)NUCB2 [DGVbeta]
DECIPHERNUCB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNUCB2 
Mutations
ICGC Data PortalNUCB2 
TCGA Data PortalNUCB2 
Broad Tumor PortalNUCB2
OASIS PortalNUCB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNUCB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNUCB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NUCB2
DgiDB (Drug Gene Interaction Database)NUCB2
DoCM (Curated mutations)NUCB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NUCB2 (select a term)
intoGenNUCB2
Cancer3DNUCB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608020   
Orphanet
MedgenNUCB2
Genetic Testing Registry NUCB2
NextProtP80303 [Medical]
TSGene4925
GENETestsNUCB2
Target ValidationNUCB2
Huge Navigator NUCB2 [HugePedia]
snp3D : Map Gene to Disease4925
BioCentury BCIQNUCB2
ClinGenNUCB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4925
Chemical/Pharm GKB GenePA31826
Clinical trialNUCB2
Miscellaneous
canSAR (ICR)NUCB2 (select the gene name)
Probes
Litterature
PubMed100 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNUCB2
EVEXNUCB2
GoPubMedNUCB2
iHOPNUCB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:02:06 CEST 2017

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