Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NUCKS1 (nuclear casein kinase and cyclin dependent kinase substrate 1)

Identity

Alias_symbol (synonym)NUCKS
Other aliasJC7
HGNC (Hugo) NUCKS1
LocusID (NCBI) 64710
Atlas_Id 51557
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 205712819 and ends at 205750244 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BMS1 (10q11.21) / NUCKS1 (1q32.1)GGA2 (16p12.2) / NUCKS1 (1q32.1)IL13RA1 (Xq24) / NUCKS1 (1q32.1)
IL1RN (2q13) / NUCKS1 (1q32.1)NUCKS1 (1q32.1) / ASRGL1 (11q12.3)NUCKS1 (1q32.1) / CCDC97 (19q13.2)
NUCKS1 (1q32.1) / NUCKS1 (1q32.1)NUCKS1 (1q32.1) / PM20D1 (1q32.1)NUCKS1 (1q32.1) / SEMA3D (7q21.11)
NUCKS1 (1q32.1) / TBL1X (Xp22.31)NUCKS1 (1q32.1) / TNFRSF10C (8p21.3)NUCKS1 (1q32.1) / WNK1 (12p13.33)
PIGN (18q21.33) / NUCKS1 (1q32.1)NUCKS1 1q32.1 / PM20D1 1q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NUCKS1   29923
Cards
Entrez_Gene (NCBI)NUCKS1  64710  nuclear casein kinase and cyclin dependent kinase substrate 1
AliasesJC7; NUCKS
GeneCards (Weizmann)NUCKS1
Ensembl hg19 (Hinxton)ENSG00000069275 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000069275 [Gene_View]  chr1:205712819-205750244 [Contig_View]  NUCKS1 [Vega]
ICGC DataPortalENSG00000069275
TCGA cBioPortalNUCKS1
AceView (NCBI)NUCKS1
Genatlas (Paris)NUCKS1
WikiGenes64710
SOURCE (Princeton)NUCKS1
Genetics Home Reference (NIH)NUCKS1
Genomic and cartography
GoldenPath hg38 (UCSC)NUCKS1  -     chr1:205712819-205750244 -  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NUCKS1  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblNUCKS1 - 1q32.1 [CytoView hg19]  NUCKS1 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBINUCKS1 [Mapview hg19]  NUCKS1 [Mapview hg38]
OMIM611912   
Gene and transcription
Genbank (Entrez)AA760780 AB049824 AF130080 AJ012584 AK025133
RefSeq transcript (Entrez)NM_022731
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NUCKS1
Cluster EST : UnigeneHs.744865 [ NCBI ]
CGAP (NCI)Hs.744865
Alternative Splicing GalleryENSG00000069275
Gene ExpressionNUCKS1 [ NCBI-GEO ]   NUCKS1 [ EBI - ARRAY_EXPRESS ]   NUCKS1 [ SEEK ]   NUCKS1 [ MEM ]
Gene Expression Viewer (FireBrowse)NUCKS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64710
GTEX Portal (Tissue expression)NUCKS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H1E3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H1E3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H1E3
Splice isoforms : SwissVarQ9H1E3
PhosPhoSitePlusQ9H1E3
Domains : Interpro (EBI)NUCKS1   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)NUCKS1
DMDM Disease mutations64710
Blocks (Seattle)NUCKS1
SuperfamilyQ9H1E3
Human Protein AtlasENSG00000069275
Peptide AtlasQ9H1E3
HPRD11406
IPIIPI00022145   IPI00844197   IPI00910634   IPI00514586   IPI00001359   
Protein Interaction databases
DIP (DOE-UCLA)Q9H1E3
IntAct (EBI)Q9H1E3
FunCoupENSG00000069275
BioGRIDNUCKS1
STRING (EMBL)NUCKS1
ZODIACNUCKS1
Ontologies - Pathways
QuickGOQ9H1E3
Ontology : AmiGOdouble-strand break repair via homologous recombination  chromatin  nuclear chromatin  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  cellular glucose homeostasis  chromatin binding  double-stranded DNA binding  single-stranded DNA binding  RNA binding  nucleus  nucleolus  cytoplasm  regulation of DNA replication  chromatin organization  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription factor binding  release from viral latency  replication fork processing  gene conversion  interstrand cross-link repair  positive regulation by host of viral transcription  positive regulation by host of viral genome replication  positive regulation of transcription from RNA polymerase II promoter  regulation of insulin receptor signaling pathway  positive regulation of insulin receptor signaling pathway  regulation of DNA strand elongation  cellular response to X-ray  modulation by host of RNA binding by virus  modulation by host of viral RNA-binding transcription factor activity  
Ontology : EGO-EBIdouble-strand break repair via homologous recombination  chromatin  nuclear chromatin  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  cellular glucose homeostasis  chromatin binding  double-stranded DNA binding  single-stranded DNA binding  RNA binding  nucleus  nucleolus  cytoplasm  regulation of DNA replication  chromatin organization  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription factor binding  release from viral latency  replication fork processing  gene conversion  interstrand cross-link repair  positive regulation by host of viral transcription  positive regulation by host of viral genome replication  positive regulation of transcription from RNA polymerase II promoter  regulation of insulin receptor signaling pathway  positive regulation of insulin receptor signaling pathway  regulation of DNA strand elongation  cellular response to X-ray  modulation by host of RNA binding by virus  modulation by host of viral RNA-binding transcription factor activity  
NDEx NetworkNUCKS1
Atlas of Cancer Signalling NetworkNUCKS1
Wikipedia pathwaysNUCKS1
Orthology - Evolution
OrthoDB64710
GeneTree (enSembl)ENSG00000069275
Phylogenetic Trees/Animal Genes : TreeFamNUCKS1
HOVERGENQ9H1E3
HOGENOMQ9H1E3
Homologs : HomoloGeneNUCKS1
Homology/Alignments : Family Browser (UCSC)NUCKS1
Gene fusions - Rearrangements
Fusion : MitelmanNUCKS1/PM20D1 [1q32.1/1q32.1]  
Fusion: TCGANUCKS1 1q32.1 PM20D1 1q32.1 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNUCKS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NUCKS1
dbVarNUCKS1
ClinVarNUCKS1
1000_GenomesNUCKS1 
Exome Variant ServerNUCKS1
ExAC (Exome Aggregation Consortium)NUCKS1 (select the gene name)
Genetic variants : HAPMAP64710
Genomic Variants (DGV)NUCKS1 [DGVbeta]
DECIPHERNUCKS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNUCKS1 
Mutations
ICGC Data PortalNUCKS1 
TCGA Data PortalNUCKS1 
Broad Tumor PortalNUCKS1
OASIS PortalNUCKS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNUCKS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNUCKS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NUCKS1
DgiDB (Drug Gene Interaction Database)NUCKS1
DoCM (Curated mutations)NUCKS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NUCKS1 (select a term)
intoGenNUCKS1
Cancer3DNUCKS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611912   
Orphanet
MedgenNUCKS1
Genetic Testing Registry NUCKS1
NextProtQ9H1E3 [Medical]
TSGene64710
GENETestsNUCKS1
Target ValidationNUCKS1
Huge Navigator NUCKS1 [HugePedia]
snp3D : Map Gene to Disease64710
BioCentury BCIQNUCKS1
ClinGenNUCKS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64710
Chemical/Pharm GKB GenePA142671244
Clinical trialNUCKS1
Miscellaneous
canSAR (ICR)NUCKS1 (select the gene name)
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNUCKS1
EVEXNUCKS1
GoPubMedNUCKS1
iHOPNUCKS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:47:37 CEST 2017

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