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NUDT1 (nudix hydrolase 1)

Identity

Alias_namesMTH1
nudix (nucleoside diphosphate linked moiety X)-type motif 1
Other alias
HGNC (Hugo) NUDT1
LocusID (NCBI) 4521
Atlas_Id 41590
Location 7p22.3  [Link to chromosome band 7p22]
Location_base_pair Starts at 2281857 and ends at 2290780 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATP6V1E1 (22q11.21) / NUDT1 (7p22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NUDT1   8048
Cards
Entrez_Gene (NCBI)NUDT1  4521  nudix hydrolase 1
AliasesMTH1
GeneCards (Weizmann)NUDT1
Ensembl hg19 (Hinxton)ENSG00000106268 [Gene_View]  chr7:2281857-2290780 [Contig_View]  NUDT1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000106268 [Gene_View]  chr7:2281857-2290780 [Contig_View]  NUDT1 [Vega]
ICGC DataPortalENSG00000106268
TCGA cBioPortalNUDT1
AceView (NCBI)NUDT1
Genatlas (Paris)NUDT1
WikiGenes4521
SOURCE (Princeton)NUDT1
Genetics Home Reference (NIH)NUDT1
Genomic and cartography
GoldenPath hg19 (UCSC)NUDT1  -     chr7:2281857-2290780 +  7p22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NUDT1  -     7p22.3   [Description]    (hg38-Dec_2013)
EnsemblNUDT1 - 7p22.3 [CytoView hg19]  NUDT1 - 7p22.3 [CytoView hg38]
Mapping of homologs : NCBINUDT1 [Mapview hg19]  NUDT1 [Mapview hg38]
OMIM600312   
Gene and transcription
Genbank (Entrez)AB025233 AB025234 AB025235 AB025236 AB025237
RefSeq transcript (Entrez)NM_002452 NM_198948 NM_198949 NM_198950 NM_198952 NM_198953 NM_198954
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007819 NW_004929329
Consensus coding sequences : CCDS (NCBI)NUDT1
Cluster EST : UnigeneHs.534331 [ NCBI ]
CGAP (NCI)Hs.534331
Alternative Splicing GalleryENSG00000106268
Gene ExpressionNUDT1 [ NCBI-GEO ]   NUDT1 [ EBI - ARRAY_EXPRESS ]   NUDT1 [ SEEK ]   NUDT1 [ MEM ]
Gene Expression Viewer (FireBrowse)NUDT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4521
GTEX Portal (Tissue expression)NUDT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36639   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36639  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36639
Splice isoforms : SwissVarP36639
Catalytic activity : Enzyme3.6.1.55 [ Enzyme-Expasy ]   3.6.1.553.6.1.55 [ IntEnz-EBI ]   3.6.1.55 [ BRENDA ]   3.6.1.55 [ KEGG ]   
PhosPhoSitePlusP36639
Domaine pattern : Prosite (Expaxy)NUDIX (PS51462)    NUDIX_BOX (PS00893)   
Domains : Interpro (EBI)Nudix_hydrolase    NUDIX_hydrolase_CS    NUDIX_hydrolase_dom    NUDIX_hydrolase_dom-like    OxG-triPHTase   
Domain families : Pfam (Sanger)NUDIX (PF00293)   
Domain families : Pfam (NCBI)pfam00293   
Conserved Domain (NCBI)NUDT1
DMDM Disease mutations4521
Blocks (Seattle)NUDT1
PDB (SRS)1IRY    3Q93    3WHW    3ZR0    3ZR1    4C9W    4C9X    4N1T    4N1U   
PDB (PDBSum)1IRY    3Q93    3WHW    3ZR0    3ZR1    4C9W    4C9X    4N1T    4N1U   
PDB (IMB)1IRY    3Q93    3WHW    3ZR0    3ZR1    4C9W    4C9X    4N1T    4N1U   
PDB (RSDB)1IRY    3Q93    3WHW    3ZR0    3ZR1    4C9W    4C9X    4N1T    4N1U   
Structural Biology KnowledgeBase1IRY    3Q93    3WHW    3ZR0    3ZR1    4C9W    4C9X    4N1T    4N1U   
SCOP (Structural Classification of Proteins)1IRY    3Q93    3WHW    3ZR0    3ZR1    4C9W    4C9X    4N1T    4N1U   
CATH (Classification of proteins structures)1IRY    3Q93    3WHW    3ZR0    3ZR1    4C9W    4C9X    4N1T    4N1U   
SuperfamilyP36639
Human Protein AtlasENSG00000106268
Peptide AtlasP36639
HPRD02634
IPIIPI00004392   IPI00759578   IPI00759462   IPI00396056   IPI00915321   
Protein Interaction databases
DIP (DOE-UCLA)P36639
IntAct (EBI)P36639
FunCoupENSG00000106268
BioGRIDNUDT1
STRING (EMBL)NUDT1
ZODIACNUDT1
Ontologies - Pathways
QuickGOP36639
Ontology : AmiGOGTPase activity  protein binding  nucleus  cytoplasm  mitochondrion  mitochondrial matrix  cytosol  purine nucleotide catabolic process  dGTP catabolic process  DNA repair  response to oxidative stress  8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity  snoRNA binding  nucleobase-containing small molecule catabolic process  8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity  8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity  GTP diphosphatase activity  DNA protection  2-hydroxy-adenosine triphosphate pyrophosphatase activity  2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity  dATP catabolic process  metal ion binding  ATP diphosphatase activity  m7G(5')pppN diphosphatase activity  extracellular exosome  
Ontology : EGO-EBIGTPase activity  protein binding  nucleus  cytoplasm  mitochondrion  mitochondrial matrix  cytosol  purine nucleotide catabolic process  dGTP catabolic process  DNA repair  response to oxidative stress  8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity  snoRNA binding  nucleobase-containing small molecule catabolic process  8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity  8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity  GTP diphosphatase activity  DNA protection  2-hydroxy-adenosine triphosphate pyrophosphatase activity  2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity  dATP catabolic process  metal ion binding  ATP diphosphatase activity  m7G(5')pppN diphosphatase activity  extracellular exosome  
NDEx NetworkNUDT1
Atlas of Cancer Signalling NetworkNUDT1
Wikipedia pathwaysNUDT1
Orthology - Evolution
OrthoDB4521
GeneTree (enSembl)ENSG00000106268
Phylogenetic Trees/Animal Genes : TreeFamNUDT1
HOVERGENP36639
HOGENOMP36639
Homologs : HomoloGeneNUDT1
Homology/Alignments : Family Browser (UCSC)NUDT1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNUDT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NUDT1
dbVarNUDT1
ClinVarNUDT1
1000_GenomesNUDT1 
Exome Variant ServerNUDT1
ExAC (Exome Aggregation Consortium)NUDT1 (select the gene name)
Genetic variants : HAPMAP4521
Genomic Variants (DGV)NUDT1 [DGVbeta]
DECIPHER (Syndromes)7:2281857-2290780  ENSG00000106268
CONAN: Copy Number AnalysisNUDT1 
Mutations
ICGC Data PortalNUDT1 
TCGA Data PortalNUDT1 
Broad Tumor PortalNUDT1
OASIS PortalNUDT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNUDT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNUDT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NUDT1
DgiDB (Drug Gene Interaction Database)NUDT1
DoCM (Curated mutations)NUDT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NUDT1 (select a term)
intoGenNUDT1
Cancer3DNUDT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600312   
Orphanet
MedgenNUDT1
Genetic Testing Registry NUDT1
NextProtP36639 [Medical]
TSGene4521
GENETestsNUDT1
Huge Navigator NUDT1 [HugePedia]
snp3D : Map Gene to Disease4521
BioCentury BCIQNUDT1
ClinGenNUDT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4521
Chemical/Pharm GKB GenePA31830
Clinical trialNUDT1
Miscellaneous
canSAR (ICR)NUDT1 (select the gene name)
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNUDT1
EVEXNUDT1
GoPubMedNUDT1
iHOPNUDT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:19:34 CET 2017

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