NUDT1 (nudix hydrolase 1)

2003-02-01  

Identity

HGNC
LOCATION
7p22.3
LOCUSID
ALIAS
MTH1
FUSION GENES

Other Information

Locus ID:

NCBI: 4521
MIM: 600312
HGNC: 8048
Ensembl: ENSG00000106268

Variants:

dbSNP: 4521
ClinVar: 4521
TCGA: ENSG00000106268
COSMIC: NUDT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106268ENST00000339737P36639
ENSG00000106268ENST00000339737A0A024R819
ENSG00000106268ENST00000343985P36639
ENSG00000106268ENST00000343985A0A024R858
ENSG00000106268ENST00000356714P36639
ENSG00000106268ENST00000356714A0A024R819
ENSG00000106268ENST00000397046P36639
ENSG00000106268ENST00000397046A0A024R819
ENSG00000106268ENST00000397048P36639
ENSG00000106268ENST00000397048A0A024R858
ENSG00000106268ENST00000397049P36639
ENSG00000106268ENST00000397049A0A024R819
ENSG00000106268ENST00000454650C9J361

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Phosphate bond hydrolysis by NUDT proteinsREACTOMER-HSA-2393930

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA1661531718-oxo-dgtpChemicalMultilinkAnnotationassociated26238318

References

Pubmed IDYearTitleCitations
246952242014MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.136
212894832011MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1.84
159315962005Germline susceptibility to colorectal cancer due to base-excision repair gene defects.61
128577382003An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress.36
278273012016Validation and development of MTH1 inhibitors for treatment of cancer.35
262383182015Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.34
250237002015MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways.31
127174532003A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides.30
272104212016Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival.25
204530002010A Large-scale genetic association study of esophageal adenocarcinoma risk.23

Citation

Dessen P

NUDT1 (nudix hydrolase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41590/nudt1