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NUDT18 (nudix hydrolase 18)

Identity

Alias_namesnudix (nucleoside diphosphate linked moiety X)-type motif 18
Alias_symbol (synonym)FLJ22494
MTH3
Other alias
HGNC (Hugo) NUDT18
LocusID (NCBI) 79873
Atlas_Id 71023
Location 8p21.3  [Link to chromosome band 8p21]
Location_base_pair Starts at 22106872 and ends at 22109419 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NUDT18   26194
Cards
Entrez_Gene (NCBI)NUDT18  79873  nudix hydrolase 18
AliasesMTH3
GeneCards (Weizmann)NUDT18
Ensembl hg19 (Hinxton)ENSG00000275074 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000275074 [Gene_View]  chr8:22106872-22109419 [Contig_View]  NUDT18 [Vega]
ICGC DataPortalENSG00000275074
TCGA cBioPortalNUDT18
AceView (NCBI)NUDT18
Genatlas (Paris)NUDT18
WikiGenes79873
SOURCE (Princeton)NUDT18
Genetics Home Reference (NIH)NUDT18
Genomic and cartography
GoldenPath hg38 (UCSC)NUDT18  -     chr8:22106872-22109419 -  8p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NUDT18  -     8p21.3   [Description]    (hg19-Feb_2009)
EnsemblNUDT18 - 8p21.3 [CytoView hg19]  NUDT18 - 8p21.3 [CytoView hg38]
Mapping of homologs : NCBINUDT18 [Mapview hg19]  NUDT18 [Mapview hg38]
OMIM615791   
Gene and transcription
Genbank (Entrez)AK026147 AK124446 BC016902 DA015404 HQ447874
RefSeq transcript (Entrez)NM_024815
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NUDT18
Cluster EST : UnigeneHs.745387 [ NCBI ]
CGAP (NCI)Hs.745387
Alternative Splicing GalleryENSG00000275074
Gene ExpressionNUDT18 [ NCBI-GEO ]   NUDT18 [ EBI - ARRAY_EXPRESS ]   NUDT18 [ SEEK ]   NUDT18 [ MEM ]
Gene Expression Viewer (FireBrowse)NUDT18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79873
GTEX Portal (Tissue expression)NUDT18
Human Protein AtlasENSG00000275074-NUDT18 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZVK8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZVK8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZVK8
Splice isoforms : SwissVarQ6ZVK8
Catalytic activity : Enzyme3.6.1.58 [ Enzyme-Expasy ]   3.6.1.583.6.1.58 [ IntEnz-EBI ]   3.6.1.58 [ BRENDA ]   3.6.1.58 [ KEGG ]   
PhosPhoSitePlusQ6ZVK8
Domaine pattern : Prosite (Expaxy)NUDIX (PS51462)    NUDIX_BOX (PS00893)   
Domains : Interpro (EBI)Nudix_hydrolase    NUDIX_hydrolase_CS    NUDIX_hydrolase_dom    NUDIX_hydrolase_dom-like   
Domain families : Pfam (Sanger)NUDIX (PF00293)   
Domain families : Pfam (NCBI)pfam00293   
Conserved Domain (NCBI)NUDT18
DMDM Disease mutations79873
Blocks (Seattle)NUDT18
PDB (SRS)3GG6    4HVY   
PDB (PDBSum)3GG6    4HVY   
PDB (IMB)3GG6    4HVY   
PDB (RSDB)3GG6    4HVY   
Structural Biology KnowledgeBase3GG6    4HVY   
SCOP (Structural Classification of Proteins)3GG6    4HVY   
CATH (Classification of proteins structures)3GG6    4HVY   
SuperfamilyQ6ZVK8
Human Protein Atlas [tissue]ENSG00000275074-NUDT18 [tissue]
Peptide AtlasQ6ZVK8
HPRD07992
IPIIPI00396292   IPI00217911   IPI00973873   IPI00980057   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZVK8
IntAct (EBI)Q6ZVK8
FunCoupENSG00000275074
BioGRIDNUDT18
STRING (EMBL)NUDT18
ZODIACNUDT18
Ontologies - Pathways
QuickGOQ6ZVK8
Ontology : AmiGOmagnesium ion binding  protein binding  cytosol  nucleobase-containing small molecule catabolic process  8-oxo-dGDP phosphatase activity  8-oxo-dGDP phosphatase activity  8-oxo-GDP phosphatase activity  8-hydroxy-dADP phosphatase activity  8-hydroxy-dADP phosphatase activity  dADP catabolic process  dGDP catabolic process  GDP catabolic process  
Ontology : EGO-EBImagnesium ion binding  protein binding  cytosol  nucleobase-containing small molecule catabolic process  8-oxo-dGDP phosphatase activity  8-oxo-dGDP phosphatase activity  8-oxo-GDP phosphatase activity  8-hydroxy-dADP phosphatase activity  8-hydroxy-dADP phosphatase activity  dADP catabolic process  dGDP catabolic process  GDP catabolic process  
NDEx NetworkNUDT18
Atlas of Cancer Signalling NetworkNUDT18
Wikipedia pathwaysNUDT18
Orthology - Evolution
OrthoDB79873
GeneTree (enSembl)ENSG00000275074
Phylogenetic Trees/Animal Genes : TreeFamNUDT18
HOVERGENQ6ZVK8
HOGENOMQ6ZVK8
Homologs : HomoloGeneNUDT18
Homology/Alignments : Family Browser (UCSC)NUDT18
Gene fusions - Rearrangements
Fusion: Tumor Portal NUDT18
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNUDT18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NUDT18
dbVarNUDT18
ClinVarNUDT18
1000_GenomesNUDT18 
Exome Variant ServerNUDT18
ExAC (Exome Aggregation Consortium)ENSG00000275074
GNOMAD BrowserENSG00000275074
Genetic variants : HAPMAP79873
Genomic Variants (DGV)NUDT18 [DGVbeta]
DECIPHERNUDT18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNUDT18 
Mutations
ICGC Data PortalNUDT18 
TCGA Data PortalNUDT18 
Broad Tumor PortalNUDT18
OASIS PortalNUDT18 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDNUDT18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NUDT18
DgiDB (Drug Gene Interaction Database)NUDT18
DoCM (Curated mutations)NUDT18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NUDT18 (select a term)
intoGenNUDT18
Cancer3DNUDT18(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615791   
Orphanet
MedgenNUDT18
Genetic Testing Registry NUDT18
NextProtQ6ZVK8 [Medical]
TSGene79873
GENETestsNUDT18
Target ValidationNUDT18
Huge Navigator NUDT18 [HugePedia]
snp3D : Map Gene to Disease79873
BioCentury BCIQNUDT18
ClinGenNUDT18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79873
Chemical/Pharm GKB GenePA142671238
Clinical trialNUDT18
Miscellaneous
canSAR (ICR)NUDT18 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNUDT18
EVEXNUDT18
GoPubMedNUDT18
iHOPNUDT18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:19:34 CET 2017

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