NUDT5 (nudix hydrolase 5)

2018-07-01  

Identity

HGNC
LOCATION
10p14
LOCUSID
ALIAS
YSA1,YSA1H,YSAH1,hNUDT5
FUSION GENES

Other Information

Locus ID:

NCBI: 11164
MIM: 609230
HGNC: 8052
Ensembl: ENSG00000165609

Variants:

dbSNP: 11164
ClinVar: 11164
TCGA: ENSG00000165609
COSMIC: NUDT5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165609ENST00000378927A6NCQ0
ENSG00000165609ENST00000378937A6NFX8
ENSG00000165609ENST00000378940A6NJU6
ENSG00000165609ENST00000444732C9JYY9
ENSG00000165609ENST00000476462H0YEY4
ENSG00000165609ENST00000491614Q9UKK9
ENSG00000165609ENST00000537776Q9UKK9

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Phosphate bond hydrolysis by NUDT proteinsREACTOMER-HSA-2393930

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
272572572016ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling.43
127174532003A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides.30
201447042010Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5.15
184627552008Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies.13
217681262011Diverse substrate recognition and hydrolysis mechanisms of human NUDT5.11
293438272018Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.9
213890462011Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein.8
222009762012Lowered nudix type 5 (NUDT5) expression leads to cell cycle retardation in HeLa cells.7
196996932009NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity.5
235818892013Lowered Nudix type 5 expression leads to cellular senescence in IMR-90 fibroblast cells.1

Citation

Dessen P

NUDT5 (nudix hydrolase 5)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57484/nudt5