Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NUF2 (NUF2 component of NDC80 kinetochore complex)

Identity

Alias (NCBI)CDCA1
CT106
NUF2R
HGNC (Hugo) NUF2
HGNC Alias symbNUF2R
CT106
HGNC Alias namecancer/testis antigen 106
HGNC Previous nameCDCA1
HGNC Previous namecell division cycle associated 1
 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
 NDC80 kinetochore complex component NUF2
LocusID (NCBI) 83540
Atlas_Id 43200
Location 1q23.3  [Link to chromosome band 1q23]
Location_base_pair Starts at 163321954 and ends at 163355759 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NUF2 (1q23.3) / TIMM17A (1q32.1)WDSUB1 (2q24.2) / NUF2 (1q23.3)NUF2 1q23.3 / TIMM17A 1q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(q23;q32) NUF2/TIMM17A

External links

Nomenclature
HGNC (Hugo)NUF2   14621
Cards
Entrez_Gene (NCBI)NUF2    NUF2 component of NDC80 kinetochore complex
AliasesCDCA1; CT106; NUF2R
GeneCards (Weizmann)NUF2
Ensembl hg19 (Hinxton)ENSG00000143228 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143228 [Gene_View]  ENSG00000143228 [Sequence]  chr1:163321954-163355759 [Contig_View]  NUF2 [Vega]
ICGC DataPortalENSG00000143228
TCGA cBioPortalNUF2
AceView (NCBI)NUF2
Genatlas (Paris)NUF2
SOURCE (Princeton)NUF2
Genetics Home Reference (NIH)NUF2
Genomic and cartography
GoldenPath hg38 (UCSC)NUF2  -     chr1:163321954-163355759 +  1q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NUF2  -     1q23.3   [Description]    (hg19-Feb_2009)
GoldenPathNUF2 - 1q23.3 [CytoView hg19]  NUF2 - 1q23.3 [CytoView hg38]
ImmunoBaseENSG00000143228
genome Data Viewer NCBINUF2 [Mapview hg19]  
OMIM611772   
Gene and transcription
Genbank (Entrez)AB050577 AB050578 AF326731 AK093348 BC008489
RefSeq transcript (Entrez)NM_031423 NM_145697
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NUF2
Alternative Splicing GalleryENSG00000143228
Gene ExpressionNUF2 [ NCBI-GEO ]   NUF2 [ EBI - ARRAY_EXPRESS ]   NUF2 [ SEEK ]   NUF2 [ MEM ]
Gene Expression Viewer (FireBrowse)NUF2 [ Firebrowse - Broad ]
GenevisibleExpression of NUF2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83540
GTEX Portal (Tissue expression)NUF2
Human Protein AtlasENSG00000143228-NUF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BZD4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BZD4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BZD4
Splice isoforms : SwissVarQ9BZD4
PhosPhoSitePlusQ9BZD4
Domains : Interpro (EBI)Kinetochore_Nuf2    Nuf2_N_sf   
Domain families : Pfam (Sanger)Nuf2 (PF03800)   
Domain families : Pfam (NCBI)pfam03800   
Conserved Domain (NCBI)NUF2
Blocks (Seattle)NUF2
PDB (RSDB)2VE7    3IZ0   
PDB Europe2VE7    3IZ0   
PDB (PDBSum)2VE7    3IZ0   
PDB (IMB)2VE7    3IZ0   
Structural Biology KnowledgeBase2VE7    3IZ0   
SCOP (Structural Classification of Proteins)2VE7    3IZ0   
CATH (Classification of proteins structures)2VE7    3IZ0   
SuperfamilyQ9BZD4
Human Protein Atlas [tissue]ENSG00000143228-NUF2 [tissue]
Peptide AtlasQ9BZD4
HPRD10817
IPIIPI00305887   IPI00645378   IPI00644780   IPI01014488   IPI00977775   IPI01010451   
Protein Interaction databases
DIP (DOE-UCLA)Q9BZD4
IntAct (EBI)Q9BZD4
BioGRIDNUF2
STRING (EMBL)NUF2
ZODIACNUF2
Ontologies - Pathways
QuickGOQ9BZD4
Ontology : AmiGOchromosome, centromeric region  condensed nuclear chromosome kinetochore  molecular_function  protein binding  nucleoplasm  cytosol  mitotic spindle organization  chromosome segregation  membrane  Ndc80 complex  Ndc80 complex  protein-containing complex binding  meiotic chromosome segregation  cell division  attachment of mitotic spindle microtubules to kinetochore  kinetochore organization  
Ontology : EGO-EBIchromosome, centromeric region  condensed nuclear chromosome kinetochore  molecular_function  protein binding  nucleoplasm  cytosol  mitotic spindle organization  chromosome segregation  membrane  Ndc80 complex  Ndc80 complex  protein-containing complex binding  meiotic chromosome segregation  cell division  attachment of mitotic spindle microtubules to kinetochore  kinetochore organization  
NDEx NetworkNUF2
Atlas of Cancer Signalling NetworkNUF2
Wikipedia pathwaysNUF2
Orthology - Evolution
OrthoDB83540
GeneTree (enSembl)ENSG00000143228
Phylogenetic Trees/Animal Genes : TreeFamNUF2
HOGENOMQ9BZD4
Homologs : HomoloGeneNUF2
Homology/Alignments : Family Browser (UCSC)NUF2
Gene fusions - Rearrangements
Fusion : MitelmanNUF2/TIMM17A [1q23.3/1q32.1]  
Fusion PortalNUF2 1q23.3 TIMM17A 1q32.1 LUAD
Fusion : QuiverNUF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNUF2 [hg38]
dbVarNUF2
ClinVarNUF2
MonarchNUF2
1000_GenomesNUF2 
Exome Variant ServerNUF2
GNOMAD BrowserENSG00000143228
Varsome BrowserNUF2
Genomic Variants (DGV)NUF2 [DGVbeta]
DECIPHERNUF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNUF2 
Mutations
ICGC Data PortalNUF2 
TCGA Data PortalNUF2 
Broad Tumor PortalNUF2
OASIS PortalNUF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNUF2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNUF2
Mutations and Diseases : HGMDNUF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NUF2
DgiDB (Drug Gene Interaction Database)NUF2
DoCM (Curated mutations)NUF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NUF2 (select a term)
intoGenNUF2
Cancer3DNUF2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611772   
Orphanet
DisGeNETNUF2
MedgenNUF2
Genetic Testing Registry NUF2
NextProtQ9BZD4 [Medical]
GENETestsNUF2
Target ValidationNUF2
Huge Navigator NUF2 [HugePedia]
ClinGenNUF2
Clinical trials, drugs, therapy
MyCancerGenomeNUF2
Protein Interactions : CTD
Pharm GKB GenePA162398215
PharosQ9BZD4
Clinical trialNUF2
Miscellaneous
canSAR (ICR)NUF2 (select the gene name)
HarmonizomeNUF2
DataMed IndexNUF2
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNUF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Jan 1 18:29:39 CET 2021
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