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NUMBL (NUMB like endocytic adaptor protein)

Identity

Alias (NCBI)CAG3A
CTG3a
NBL
NUMB-R
NUMBLIKE
NUMBR
TNRC23
HGNC (Hugo) NUMBL
HGNC Alias symbNUMB-R
CTG3a
CAG3A
TNRC23
NUMBR
NUMBLIKE
HGNC Previous namenumb (Drosophila) homolog-like
LocusID (NCBI) 9253
Atlas_Id 47456
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 40665906 and ends at 40690651 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADCK4 (19q13.2) / NUMBL (19q13.2)NUMBL (19q13.2) / CBX6 (22q13.1)PRNP (20p13) / NUMBL (19q13.2)
PRR12 (19q13.33) / NUMBL (19q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)NUMBL   8061
Cards
Entrez_Gene (NCBI)NUMBL    NUMB like endocytic adaptor protein
AliasesCAG3A; CTG3a; NBL; NUMB-R; 
NUMBLIKE; NUMBR; TNRC23
GeneCards (Weizmann)NUMBL
Ensembl hg19 (Hinxton)ENSG00000105245 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105245 [Gene_View]  ENSG00000105245 [Sequence]  chr19:40665906-40690651 [Contig_View]  NUMBL [Vega]
ICGC DataPortalENSG00000105245
TCGA cBioPortalNUMBL
AceView (NCBI)NUMBL
Genatlas (Paris)NUMBL
SOURCE (Princeton)NUMBL
Genetics Home Reference (NIH)NUMBL
Genomic and cartography
GoldenPath hg38 (UCSC)NUMBL  -     chr19:40665906-40690651 -  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NUMBL  -     19q13.2   [Description]    (hg19-Feb_2009)
GoldenPathNUMBL - 19q13.2 [CytoView hg19]  NUMBL - 19q13.2 [CytoView hg38]
ImmunoBaseENSG00000105245
Genome Data Viewer NCBINUMBL [Mapview hg19]  
OMIM604018   
Gene and transcription
Genbank (Entrez)AF015041 AI374943 AK289398 AK299484 BC001794
RefSeq transcript (Entrez)NM_001289979 NM_001289980 NM_004756
Consensus coding sequences : CCDS (NCBI)NUMBL
Gene ExpressionNUMBL [ NCBI-GEO ]   NUMBL [ EBI - ARRAY_EXPRESS ]   NUMBL [ SEEK ]   NUMBL [ MEM ]
Gene Expression Viewer (FireBrowse)NUMBL [ Firebrowse - Broad ]
GenevisibleExpression of NUMBL in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9253
GTEX Portal (Tissue expression)NUMBL
Human Protein AtlasENSG00000105245-NUMBL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6R0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6R0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6R0
PhosPhoSitePlusQ9Y6R0
Domaine pattern : Prosite (Expaxy)PID (PS01179)   
Domains : Interpro (EBI)Numb/numb-like    Numb_domain    PH-like_dom_sf    PTB/PI_dom   
Domain families : Pfam (Sanger)NumbF (PF06311)    PID (PF00640)   
Domain families : Pfam (NCBI)pfam06311    pfam00640   
Domain families : Smart (EMBL)PTB (SM00462)  
Conserved Domain (NCBI)NUMBL
PDB (RSDB)3F0W   
PDB Europe3F0W   
PDB (PDBSum)3F0W   
PDB (IMB)3F0W   
Structural Biology KnowledgeBase3F0W   
SCOP (Structural Classification of Proteins)3F0W   
CATH (Classification of proteins structures)3F0W   
SuperfamilyQ9Y6R0
AlphaFold pdb e-kbQ9Y6R0   
Human Protein Atlas [tissue]ENSG00000105245-NUMBL [tissue]
HPRD04931
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6R0
IntAct (EBI)Q9Y6R0
BioGRIDNUMBL
STRING (EMBL)NUMBL
ZODIACNUMBL
Ontologies - Pathways
QuickGOQ9Y6R0
Ontology : AmiGOprotein binding  cytoplasm  nervous system development  axonogenesis  cytokine-mediated signaling pathway  protein metabolic process  lateral ventricle development  neuroblast division in subventricular zone  adherens junction organization  positive regulation of neurogenesis  
Ontology : EGO-EBIprotein binding  cytoplasm  nervous system development  axonogenesis  cytokine-mediated signaling pathway  protein metabolic process  lateral ventricle development  neuroblast division in subventricular zone  adherens junction organization  positive regulation of neurogenesis  
Pathways : KEGGNotch signaling pathway   
NDEx NetworkNUMBL
Atlas of Cancer Signalling NetworkNUMBL
Wikipedia pathwaysNUMBL
Orthology - Evolution
OrthoDB9253
GeneTree (enSembl)ENSG00000105245
Phylogenetic Trees/Animal Genes : TreeFamNUMBL
Homologs : HomoloGeneNUMBL
Homology/Alignments : Family Browser (UCSC)NUMBL
Gene fusions - Rearrangements
Fusion : MitelmanADCK4/NUMBL [19q13.2/19q13.2]  
Fusion : QuiverNUMBL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNUMBL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NUMBL
dbVarNUMBL
ClinVarNUMBL
MonarchNUMBL
1000_GenomesNUMBL 
Exome Variant ServerNUMBL
GNOMAD BrowserENSG00000105245
Varsome BrowserNUMBL
ACMGNUMBL variants
VarityQ9Y6R0
Genomic Variants (DGV)NUMBL [DGVbeta]
DECIPHERNUMBL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNUMBL 
Mutations
ICGC Data PortalNUMBL 
TCGA Data PortalNUMBL 
Broad Tumor PortalNUMBL
OASIS PortalNUMBL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNUMBL  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNUMBL
Mutations and Diseases : HGMDNUMBL
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNUMBL
DgiDB (Drug Gene Interaction Database)NUMBL
DoCM (Curated mutations)NUMBL
CIViC (Clinical Interpretations of Variants in Cancer)NUMBL
Cancer3DNUMBL
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604018   
Orphanet
DisGeNETNUMBL
MedgenNUMBL
Genetic Testing Registry NUMBL
NextProtQ9Y6R0 [Medical]
GENETestsNUMBL
Target ValidationNUMBL
Huge Navigator NUMBL [HugePedia]
ClinGenNUMBL
Clinical trials, drugs, therapy
MyCancerGenomeNUMBL
Protein Interactions : CTDNUMBL
Pharm GKB GenePA31846
PharosQ9Y6R0
Clinical trialNUMBL
Miscellaneous
canSAR (ICR)NUMBL
HarmonizomeNUMBL
DataMed IndexNUMBL
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNUMBL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:23:31 CEST 2021
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