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NUP153 (nucleoporin 153)

Identity

Alias_namesnucleoporin 153kDa
Alias_symbol (synonym)HNUP153
Other aliasN153
HGNC (Hugo) NUP153
LocusID (NCBI) 9972
Atlas_Id 46894
Location 6p22.3  [Link to chromosome band 6p22]
Location_base_pair Starts at 17615037 and ends at 17706925 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NUP153 (6p22.3) / C3orf67 (3p14.2)NUP153 (6p22.3) / GCNT2 (6p24.3)NUP153 (6p22.3) / NEDD9 (6p24.2)
NUP153 (6p22.3) / NTNG2 (9q34.13)NUP153 (6p22.3) / NUP153 (6p22.3)NUP153 (6p22.3) / RNF2 (1q25.3)
NUP153 (6p22.3) / ZNF280C (Xq26.1)NUP153 6p22.3 / GCNT2 6p24.3NUP153 6p22.3 / NEDD9 6p24.2
NUP153 6p22.3 / RNF2 1q25.3NUP153 6p22.3 / ZNF280C Xq26.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;9)(p22;q34) NUP153/ABL1

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(1;6)(q25;p22) NUP153/RNF2
t(6;6)(p22;p24) NUP153/GCNT2
t(6;6)(p22;p24) NUP153/NEDD9
t(6;9)(p22;q34) NUP153/NTNG2
t(X;6)(q26;p22) NUP153/ZNF280C

External links

Nomenclature
HGNC (Hugo)NUP153   8062
Cards
Entrez_Gene (NCBI)NUP153  9972  nucleoporin 153
AliasesHNUP153; N153
GeneCards (Weizmann)NUP153
Ensembl hg19 (Hinxton)ENSG00000124789 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124789 [Gene_View]  ENSG00000124789 [Sequence]  chr6:17615037-17706925 [Contig_View]  NUP153 [Vega]
ICGC DataPortalENSG00000124789
TCGA cBioPortalNUP153
AceView (NCBI)NUP153
Genatlas (Paris)NUP153
WikiGenes9972
SOURCE (Princeton)NUP153
Genetics Home Reference (NIH)NUP153
Genomic and cartography
GoldenPath hg38 (UCSC)NUP153  -     chr6:17615037-17706925 -  6p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NUP153  -     6p22.3   [Description]    (hg19-Feb_2009)
GoldenPathNUP153 - 6p22.3 [CytoView hg19]  NUP153 - 6p22.3 [CytoView hg38]
Genome Data Viewer NCBINUP153 [Mapview hg19]  
OMIM603948   
Gene and transcription
Genbank (Entrez)AB210024 AI948895 AK295644 AL597150 AW269393
RefSeq transcript (Entrez)NM_001278209 NM_001278210 NM_005124
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NUP153
Alternative Splicing GalleryENSG00000124789
Gene ExpressionNUP153 [ NCBI-GEO ]   NUP153 [ EBI - ARRAY_EXPRESS ]   NUP153 [ SEEK ]   NUP153 [ MEM ]
Gene Expression Viewer (FireBrowse)NUP153 [ Firebrowse - Broad ]
GenevisibleExpression of NUP153 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9972
GTEX Portal (Tissue expression)NUP153
Human Protein AtlasENSG00000124789-NUP153 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49790   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49790  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49790
Splice isoforms : SwissVarP49790
PhosPhoSitePlusP49790
Domaine pattern : Prosite (Expaxy)ZF_RANBP2_1 (PS01358)    ZF_RANBP2_2 (PS50199)   
Domains : Interpro (EBI)Nucleoporin    Nup153_N    Retro-transposon_transp_CS    Znf_RanBP2    Znf_RanBP2_sf   
Domain families : Pfam (Sanger)Nup153 (PF08604)    Nup_retrotrp_bd (PF10599)    zf-RanBP (PF00641)   
Domain families : Pfam (NCBI)pfam08604    pfam10599    pfam00641   
Domain families : Smart (EMBL)ZnF_RBZ (SM00547)  
Conserved Domain (NCBI)NUP153
DMDM Disease mutations9972
PDB (RSDB)2EBQ    2EBR    2EBV    2GQE    4U0C    4U0D    5TSV    5TSX    6AYA   
PDB Europe2EBQ    2EBR    2EBV    2GQE    4U0C    4U0D    5TSV    5TSX    6AYA   
PDB (PDBSum)2EBQ    2EBR    2EBV    2GQE    4U0C    4U0D    5TSV    5TSX    6AYA   
PDB (IMB)2EBQ    2EBR    2EBV    2GQE    4U0C    4U0D    5TSV    5TSX    6AYA   
Structural Biology KnowledgeBase2EBQ    2EBR    2EBV    2GQE    4U0C    4U0D    5TSV    5TSX    6AYA   
SCOP (Structural Classification of Proteins)2EBQ    2EBR    2EBV    2GQE    4U0C    4U0D    5TSV    5TSX    6AYA   
CATH (Classification of proteins structures)2EBQ    2EBR    2EBV    2GQE    4U0C    4U0D    5TSV    5TSX    6AYA   
SuperfamilyP49790
Human Protein Atlas [tissue]ENSG00000124789-NUP153 [tissue]
Peptide AtlasP49790
HPRD04899
IPIIPI00292059   IPI00910194   IPI01015047   IPI00743364   
Protein Interaction databases
DIP (DOE-UCLA)P49790
IntAct (EBI)P49790
FunCoupENSG00000124789
BioGRIDNUP153
STRING (EMBL)NUP153
ZODIACNUP153
Ontologies - Pathways
QuickGOP49790
Ontology : AmiGODNA binding  protein binding  nuclear pore  nucleoplasm  nucleolus  cytosol  regulation of glycolytic process  RNA export from nucleus  mRNA export from nucleus  tRNA export from nucleus  protein import into nucleus  nuclear localization sequence binding  membrane  viral process  protein sumoylation  structural constituent of nuclear pore  structural constituent of nuclear pore  structural constituent of nuclear pore  viral transcription  nuclear membrane  nuclear periphery  nuclear inclusion body  identical protein binding  protein membrane anchor  host cell  nuclear pore central transport channel  nuclear pore nuclear basket  nuclear pore nuclear basket  viral entry into host cell  negative regulation of RNA export from nucleus  metal ion binding  nuclear pore complex assembly  regulation of gene silencing by miRNA  viral penetration into host nucleus  intracellular transport of virus  regulation of cellular response to heat  
Ontology : EGO-EBIDNA binding  protein binding  nuclear pore  nucleoplasm  nucleolus  cytosol  regulation of glycolytic process  RNA export from nucleus  mRNA export from nucleus  tRNA export from nucleus  protein import into nucleus  nuclear localization sequence binding  membrane  viral process  protein sumoylation  structural constituent of nuclear pore  structural constituent of nuclear pore  structural constituent of nuclear pore  viral transcription  nuclear membrane  nuclear periphery  nuclear inclusion body  identical protein binding  protein membrane anchor  host cell  nuclear pore central transport channel  nuclear pore nuclear basket  nuclear pore nuclear basket  viral entry into host cell  negative regulation of RNA export from nucleus  metal ion binding  nuclear pore complex assembly  regulation of gene silencing by miRNA  viral penetration into host nucleus  intracellular transport of virus  regulation of cellular response to heat  
Pathways : KEGGRNA transport   
NDEx NetworkNUP153
Atlas of Cancer Signalling NetworkNUP153
Wikipedia pathwaysNUP153
Orthology - Evolution
OrthoDB9972
GeneTree (enSembl)ENSG00000124789
Phylogenetic Trees/Animal Genes : TreeFamNUP153
HOGENOMP49790
Homologs : HomoloGeneNUP153
Homology/Alignments : Family Browser (UCSC)NUP153
Gene fusions - Rearrangements
Fusion : MitelmanNUP153/C3orf67 [6p22.3/3p14.2]  
Fusion : MitelmanNUP153/GCNT2 [6p22.3/6p24.3]  
Fusion : MitelmanNUP153/NEDD9 [6p22.3/6p24.2]  
Fusion : MitelmanNUP153/NTNG2 [6p22.3/9q34.13]  
Fusion : MitelmanNUP153/RNF2 [6p22.3/1q25.3]  
Fusion : MitelmanNUP153/ZNF280C [6p22.3/Xq26.1]  
Fusion PortalNUP153 6p22.3 GCNT2 6p24.3 BRCA
Fusion PortalNUP153 6p22.3 NEDD9 6p24.2 BRCA
Fusion PortalNUP153 6p22.3 RNF2 1q25.3 BRCA
Fusion PortalNUP153 6p22.3 ZNF280C Xq26.1 BRCA
Fusion : QuiverNUP153
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNUP153 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NUP153
dbVarNUP153
ClinVarNUP153
1000_GenomesNUP153 
Exome Variant ServerNUP153
GNOMAD BrowserENSG00000124789
Varsome BrowserNUP153
Genetic variants : HAPMAP9972
Genomic Variants (DGV)NUP153 [DGVbeta]
DECIPHERNUP153 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNUP153 
Mutations
ICGC Data PortalNUP153 
TCGA Data PortalNUP153 
Broad Tumor PortalNUP153
OASIS PortalNUP153 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNUP153  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNUP153
Mutations and Diseases : HGMDNUP153
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect NUP153
DgiDB (Drug Gene Interaction Database)NUP153
DoCM (Curated mutations)NUP153 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NUP153 (select a term)
intoGenNUP153
Cancer3DNUP153 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603948   
Orphanet
DisGeNETNUP153
MedgenNUP153
Genetic Testing Registry NUP153
NextProtP49790 [Medical]
TSGene9972
GENETestsNUP153
Open Targets GeneticsENSG00000124789  [validation]
snp3D : Map Gene to Disease9972
BioCentury BCIQNUP153
ClinGenNUP153
Clinical trials, drugs, therapy
Protein Interactions : CTD9972
Pharm GKB GenePA31848
Clinical trialNUP153
Miscellaneous
canSAR (ICR)NUP153 (select the gene name)
HarmonizomeNUP153
DataMed IndexNUP153
Probes
Litterature
PubMed166 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNUP153
EVEXNUP153
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 20:03:12 CEST 2020
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