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NUP153 (nucleoporin 153)

Identity

Alias (NCBI)HNUP153
N153
HGNC (Hugo) NUP153
HGNC Alias symbHNUP153
HGNC Previous namenucleoporin 153kDa
LocusID (NCBI) 9972
Atlas_Id 46894
Location 6p22.3  [Link to chromosome band 6p22]
Location_base_pair Starts at 17615037 and ends at 17706925 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NUP153 (6p22.3)::C3orf67 (3p14.2)NUP153 (6p22.3)::GCNT2 (6p24.3)NUP153 (6p22.3)::NEDD9 (6p24.2)
NUP153 (6p22.3)::NTNG2 (9q34.13)NUP153 (6p22.3)::NUP153 (6p22.3)NUP153 (6p22.3)::RNF2 (1q25.3)
NUP153 (6p22.3)::ZNF280C (Xq26.1)NUP153 6p22.3::GCNT2 6p24.3NUP153 6p22.3::NEDD9 6p24.2
NUP153 6p22.3::RNF2 1q25.3NUP153 6p22.3::ZNF280C Xq26.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;9)(p22;q34) NUP153::ABL1

External links

 

Nomenclature
HGNC (Hugo)NUP153   8062
Cards
Entrez_Gene (NCBI)NUP153    nucleoporin 153
AliasesHNUP153; N153
GeneCards (Weizmann)NUP153
Ensembl hg19 (Hinxton)ENSG00000124789 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124789 [Gene_View]  ENSG00000124789 [Sequence]  chr6:17615037-17706925 [Contig_View]  NUP153 [Vega]
ICGC DataPortalENSG00000124789
TCGA cBioPortalNUP153
AceView (NCBI)NUP153
Genatlas (Paris)NUP153
SOURCE (Princeton)NUP153
Genetics Home Reference (NIH)NUP153
Genomic and cartography
GoldenPath hg38 (UCSC)NUP153  -     chr6:17615037-17706925 -  6p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NUP153  -     6p22.3   [Description]    (hg19-Feb_2009)
GoldenPathNUP153 - 6p22.3 [CytoView hg19]  NUP153 - 6p22.3 [CytoView hg38]
ImmunoBaseENSG00000124789
Genome Data Viewer NCBINUP153 [Mapview hg19]  
OMIM603948   
Gene and transcription
Genbank (Entrez)AB210024 AI948895 AK295644 AL597150 AW269393
RefSeq transcript (Entrez)NM_001278209 NM_001278210 NM_005124
Consensus coding sequences : CCDS (NCBI)NUP153
Gene ExpressionNUP153 [ NCBI-GEO ]   NUP153 [ EBI - ARRAY_EXPRESS ]   NUP153 [ SEEK ]   NUP153 [ MEM ]
Gene Expression Viewer (FireBrowse)NUP153 [ Firebrowse - Broad ]
GenevisibleExpression of NUP153 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9972
GTEX Portal (Tissue expression)NUP153
Human Protein AtlasENSG00000124789-NUP153 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49790   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49790  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49790
PhosPhoSitePlusP49790
Domaine pattern : Prosite (Expaxy)ZF_RANBP2_1 (PS01358)    ZF_RANBP2_2 (PS50199)   
Domains : Interpro (EBI)Nucleoporin    Nup153_N    Retro-transposon_transp_CS    Znf_RanBP2    Znf_RanBP2_sf   
Domain families : Pfam (Sanger)Nup153 (PF08604)    Nup_retrotrp_bd (PF10599)    zf-RanBP (PF00641)   
Domain families : Pfam (NCBI)pfam08604    pfam10599    pfam00641   
Domain families : Smart (EMBL)ZnF_RBZ (SM00547)  
Conserved Domain (NCBI)NUP153
PDB (RSDB)2EBQ    2EBR    2EBV    2GQE    4U0C    4U0D    5TSV    5TSX    6AYA   
PDB Europe2EBQ    2EBR    2EBV    2GQE    4U0C    4U0D    5TSV    5TSX    6AYA   
PDB (PDBSum)2EBQ    2EBR    2EBV    2GQE    4U0C    4U0D    5TSV    5TSX    6AYA   
PDB (IMB)2EBQ    2EBR    2EBV    2GQE    4U0C    4U0D    5TSV    5TSX    6AYA   
Structural Biology KnowledgeBase2EBQ    2EBR    2EBV    2GQE    4U0C    4U0D    5TSV    5TSX    6AYA   
SCOP (Structural Classification of Proteins)2EBQ    2EBR    2EBV    2GQE    4U0C    4U0D    5TSV    5TSX    6AYA   
CATH (Classification of proteins structures)2EBQ    2EBR    2EBV    2GQE    4U0C    4U0D    5TSV    5TSX    6AYA   
SuperfamilyP49790
AlphaFold pdb e-kbP49790   
Human Protein Atlas [tissue]ENSG00000124789-NUP153 [tissue]
HPRD04899
Protein Interaction databases
DIP (DOE-UCLA)P49790
IntAct (EBI)P49790
BioGRIDNUP153
STRING (EMBL)NUP153
ZODIACNUP153
Ontologies - Pathways
QuickGOP49790
Ontology : AmiGODNA binding  protein binding  nuclear envelope  nuclear pore  nuclear pore  nucleoplasm  nucleoplasm  nucleolus  cytosol  RNA export from nucleus  protein import into nucleus  nuclear localization sequence binding  membrane  structural constituent of nuclear pore  structural constituent of nuclear pore  structural constituent of nuclear pore  nuclear membrane  nuclear periphery  nuclear inclusion body  identical protein binding  protein-membrane adaptor activity  host cell  nuclear pore nuclear basket  viral entry into host cell  negative regulation of RNA export from nucleus  metal ion binding  mRNA transport  nuclear pore complex assembly  viral penetration into host nucleus  
Ontology : EGO-EBIDNA binding  protein binding  nuclear envelope  nuclear pore  nuclear pore  nucleoplasm  nucleoplasm  nucleolus  cytosol  RNA export from nucleus  protein import into nucleus  nuclear localization sequence binding  membrane  structural constituent of nuclear pore  structural constituent of nuclear pore  structural constituent of nuclear pore  nuclear membrane  nuclear periphery  nuclear inclusion body  identical protein binding  protein-membrane adaptor activity  host cell  nuclear pore nuclear basket  viral entry into host cell  negative regulation of RNA export from nucleus  metal ion binding  mRNA transport  nuclear pore complex assembly  viral penetration into host nucleus  
Pathways : BIOCARTABIOCARTA_NPCPATHWAY   
NDEx NetworkNUP153
Atlas of Cancer Signalling NetworkNUP153
Wikipedia pathwaysNUP153
Orthology - Evolution
OrthoDB9972
GeneTree (enSembl)ENSG00000124789
Phylogenetic Trees/Animal Genes : TreeFamNUP153
Homologs : HomoloGeneNUP153
Homology/Alignments : Family Browser (UCSC)NUP153
Gene fusions - Rearrangements
Fusion : MitelmanNUP153::C3orf67 [6p22.3/3p14.2]  
Fusion : MitelmanNUP153::GCNT2 [6p22.3/6p24.3]  
Fusion : MitelmanNUP153::NEDD9 [6p22.3/6p24.2]  
Fusion : MitelmanNUP153::NTNG2 [6p22.3/9q34.13]  
Fusion : MitelmanNUP153::RNF2 [6p22.3/1q25.3]  
Fusion : MitelmanNUP153::ZNF280C [6p22.3/Xq26.1]  
Fusion : QuiverNUP153
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNUP153 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NUP153
dbVarNUP153
ClinVarNUP153
MonarchNUP153
1000_GenomesNUP153 
Exome Variant ServerNUP153
GNOMAD BrowserENSG00000124789
Varsome BrowserNUP153
ACMGNUP153 variants
VarityP49790
Genomic Variants (DGV)NUP153 [DGVbeta]
DECIPHERNUP153 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNUP153 
Mutations
ICGC Data PortalNUP153 
TCGA Data PortalNUP153 
Broad Tumor PortalNUP153
OASIS PortalNUP153 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNUP153  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNUP153
Mutations and Diseases : HGMDNUP153
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNUP153
DgiDB (Drug Gene Interaction Database)NUP153
DoCM (Curated mutations)NUP153
CIViC (Clinical Interpretations of Variants in Cancer)NUP153
Cancer3DNUP153
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603948   
Orphanet
DisGeNETNUP153
MedgenNUP153
Genetic Testing Registry NUP153
NextProtP49790 [Medical]
GENETestsNUP153
Target ValidationNUP153
Huge Navigator NUP153 [HugePedia]
ClinGenNUP153
Clinical trials, drugs, therapy
MyCancerGenomeNUP153
Protein Interactions : CTDNUP153
Pharm GKB GenePA31848
PharosP49790
Clinical trialNUP153
Miscellaneous
canSAR (ICR)NUP153
HarmonizomeNUP153
ARCHS4NUP153
DataMed IndexNUP153
Probes
Litterature
PubMed190 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNUP153
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:50:15 CET 2022
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