NUP62 (nucleoporin 62)

2016-05-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
IBSN,SNDI,p62

Other Information

Locus ID:

NCBI: 23636
MIM: 605815
HGNC: 8066
Ensembl: ENSG00000213024

Variants:

dbSNP: 23636
ClinVar: 23636
TCGA: ENSG00000213024
COSMIC: NUP62

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213024ENST00000352066P37198
ENSG00000213024ENST00000352066A0A024QZF1
ENSG00000213024ENST00000422090P37198
ENSG00000213024ENST00000422090A0A024QZF1
ENSG00000213024ENST00000593652M0R302
ENSG00000213024ENST00000594673M0QYY0
ENSG00000213024ENST00000595761M0QX64
ENSG00000213024ENST00000596217P37198
ENSG00000213024ENST00000596217A0A024QZF1
ENSG00000213024ENST00000596437M0QX13
ENSG00000213024ENST00000596680M0R0B7
ENSG00000213024ENST00000597029P37198
ENSG00000213024ENST00000597029A0A024QZF1
ENSG00000213024ENST00000597723M0QXN5
ENSG00000213024ENST00000599567M0R1S1
ENSG00000213024ENST00000599788M0QX10
ENSG00000213024ENST00000600645M0QZL5
ENSG00000213024ENST00000600935M0QX10

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Nuclear pore complexKEGGhsa_M00427
Nuclear pore complexKEGGM00427
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Rev-mediated nuclear export of HIV RNAREACTOMER-HSA-165054
Host Interactions of HIV factorsREACTOMER-HSA-162909
Interactions of Vpr with host cellular proteinsREACTOMER-HSA-176033
Vpr-mediated nuclear import of PICsREACTOMER-HSA-180910
Interactions of Rev with host cellular proteinsREACTOMER-HSA-177243
Nuclear import of Rev proteinREACTOMER-HSA-180746
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Transport of Ribonucleoproteins into the Host NucleusREACTOMER-HSA-168271
Influenza Viral RNA Transcription and ReplicationREACTOMER-HSA-168273
Viral Messenger RNA SynthesisREACTOMER-HSA-168325
Export of Viral Ribonucleoproteins from NucleusREACTOMER-HSA-168274
NEP/NS2 Interacts with the Cellular Export MachineryREACTOMER-HSA-168333
Host Interactions with Influenza FactorsREACTOMER-HSA-168253
NS1 Mediated Effects on Host PathwaysREACTOMER-HSA-168276
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236
Transport of Mature mRNAs Derived from Intronless TranscriptsREACTOMER-HSA-159234
Transport of the SLBP Dependant Mature mRNAREACTOMER-HSA-159230
Transport of the SLBP independent Mature mRNAREACTOMER-HSA-159227
Transport of Mature mRNA Derived from an Intronless TranscriptREACTOMER-HSA-159231
Gene Silencing by RNAREACTOMER-HSA-211000
Transcriptional regulation by small RNAsREACTOMER-HSA-5578749
Metabolism of non-coding RNAREACTOMER-HSA-194441
snRNP AssemblyREACTOMER-HSA-191859
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Nuclear Envelope BreakdownREACTOMER-HSA-2980766
Nuclear Pore Complex (NPC) DisassemblyREACTOMER-HSA-3301854
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Hexose transportREACTOMER-HSA-189200
Glucose transportREACTOMER-HSA-70153
Regulation of Glucokinase by Glucokinase Regulatory ProteinREACTOMER-HSA-170822
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453
tRNA processingREACTOMER-HSA-72306
tRNA processing in the nucleusREACTOMER-HSA-6784531
SUMOylation of RNA binding proteinsREACTOMER-HSA-4570464
SUMOylation of DNA replication proteinsREACTOMER-HSA-4615885

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
121635992002Inhibition of nuclear import and alteration of nuclear pore complex composition by rhinovirus.89
206220122010Specific cleavage of the nuclear pore complex protein Nup62 by a viral protease.53
198287352009Oxidative stress inhibits nuclear protein export by multiple mechanisms that target FG nucleoporins and Crm1.37
167865272006Mutated nup62 causes autosomal recessive infantile bilateral striatal necrosis.36
191447122009Mengovirus-induced rearrangement of the nuclear pore complex: hijacking cellular phosphorylation machinery.32
247391742014Karyopherin-centric control of nuclear pores based on molecular occupancy and kinetic analysis of multivalent binding with FG nucleoporins.32
223346722012Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathways.26
216982672011OSBP-related protein 8 (ORP8) regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62.19
223080262012Contribution of host nucleoporin 62 in HIV-1 integrase chromatin association and viral DNA integration.17
241076302013Nucleoporin Nup62 maintains centrosome homeostasis.17

Citation

Dessen P

NUP62 (nucleoporin 62)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55780/nup62