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NUP85 (nucleoporin 85)

Identity

Alias (NCBI)FROUNT
NPHS17
Nup75
HGNC (Hugo) NUP85
HGNC Alias symbNUP75
FLJ12549
HGNC Previous namenucleoporin 85kDa
LocusID (NCBI) 79902
Atlas_Id 71049
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 75205450 and ends at 75235759 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MYO15B (17q25.1) / NUP85 (17q25.1)NUP85 (17q25.1) / GPC3 (Xq26.2)NUP85 (17q25.1) / KCTD2 (17q25.1)
NUP85 (17q25.1) / NUP85 (17q25.1)NUP85 (17q25.1) / SUMO2 (17q25.1)NUP85 (17q25.1) / ZDHHC18 (1p36.11)
PPM1D (17q23.2) / NUP85 (17q25.1)TMEM94 (17q25.1) / NUP85 (17q25.1)WBP2 (17q25.1) / NUP85 (17q25.1)
ZNF77 (19p13.3) / NUP85 (17q25.1)NUP85 ZDHHC18NUP85 KCTD2
PPM1D NUP85KIAA0195 NUP85

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(1;17)(p36;q25) NUP85/ZDHHC18
t(X;17)(q26;q25) NUP85/GPC3
t(17;17)(q23;q25) PPM1D/NUP85
MYO15B/NUP85 (17q25)
NUP85/KCTD2 (17q25)


External links

Nomenclature
HGNC (Hugo)NUP85   8734
Cards
Entrez_Gene (NCBI)NUP85    nucleoporin 85
AliasesFROUNT; NPHS17; Nup75
GeneCards (Weizmann)NUP85
Ensembl hg19 (Hinxton)ENSG00000125450 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125450 [Gene_View]  ENSG00000125450 [Sequence]  chr17:75205450-75235759 [Contig_View]  NUP85 [Vega]
ICGC DataPortalENSG00000125450
TCGA cBioPortalNUP85
AceView (NCBI)NUP85
Genatlas (Paris)NUP85
SOURCE (Princeton)NUP85
Genetics Home Reference (NIH)NUP85
Genomic and cartography
GoldenPath hg38 (UCSC)NUP85  -     chr17:75205450-75235759 +  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NUP85  -     17q25.1   [Description]    (hg19-Feb_2009)
GoldenPathNUP85 - 17q25.1 [CytoView hg19]  NUP85 - 17q25.1 [CytoView hg38]
ImmunoBaseENSG00000125450
genome Data Viewer NCBINUP85 [Mapview hg19]  
OMIM170285   618176   
Gene and transcription
Genbank (Entrez)AF498261 AF514995 AK022611 AK124501 AK295694
RefSeq transcript (Entrez)NM_001303276 NM_001330472 NM_024844
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NUP85
Alternative Splicing GalleryENSG00000125450
Gene ExpressionNUP85 [ NCBI-GEO ]   NUP85 [ EBI - ARRAY_EXPRESS ]   NUP85 [ SEEK ]   NUP85 [ MEM ]
Gene Expression Viewer (FireBrowse)NUP85 [ Firebrowse - Broad ]
GenevisibleExpression of NUP85 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79902
GTEX Portal (Tissue expression)NUP85
Human Protein AtlasENSG00000125450-NUP85 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BW27   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BW27  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BW27
Splice isoforms : SwissVarQ9BW27
PhosPhoSitePlusQ9BW27
Domains : Interpro (EBI)Nucleoporin_Nup85   
Domain families : Pfam (Sanger)Nucleopor_Nup85 (PF07575)   
Domain families : Pfam (NCBI)pfam07575   
Conserved Domain (NCBI)NUP85
Blocks (Seattle)NUP85
PDB (RSDB)5A9Q   
PDB Europe5A9Q   
PDB (PDBSum)5A9Q   
PDB (IMB)5A9Q   
Structural Biology KnowledgeBase5A9Q   
SCOP (Structural Classification of Proteins)5A9Q   
CATH (Classification of proteins structures)5A9Q   
SuperfamilyQ9BW27
Human Protein Atlas [tissue]ENSG00000125450-NUP85 [tissue]
Peptide AtlasQ9BW27
HPRD01363
IPIIPI00790530   IPI01014661   IPI00909193   IPI00909272   IPI01013027   IPI00888760   
Protein Interaction databases
DIP (DOE-UCLA)Q9BW27
IntAct (EBI)Q9BW27
BioGRIDNUP85
STRING (EMBL)NUP85
ZODIACNUP85
Ontologies - Pathways
QuickGOQ9BW27
Ontology : AmiGOkinetochore  condensed chromosome kinetochore  protein binding  nuclear envelope  nucleoplasm  spindle  cytosol  cytosol  regulation of glycolytic process  mRNA export from nucleus  mRNA export from nucleus  tRNA export from nucleus  protein import into nucleus  membrane  viral process  protein sumoylation  structural constituent of nuclear pore  viral transcription  lamellipodium assembly  nuclear pore outer ring  nuclear pore outer ring  nuclear pore outer ring  nuclear membrane  host cell  positive regulation of transcription, DNA-templated  macrophage chemotaxis  regulation of gene silencing by miRNA  nephron development  intracellular transport of virus  regulation of cellular response to heat  
Ontology : EGO-EBIkinetochore  condensed chromosome kinetochore  protein binding  nuclear envelope  nucleoplasm  spindle  cytosol  cytosol  regulation of glycolytic process  mRNA export from nucleus  mRNA export from nucleus  tRNA export from nucleus  protein import into nucleus  membrane  viral process  protein sumoylation  structural constituent of nuclear pore  viral transcription  lamellipodium assembly  nuclear pore outer ring  nuclear pore outer ring  nuclear pore outer ring  nuclear membrane  host cell  positive regulation of transcription, DNA-templated  macrophage chemotaxis  regulation of gene silencing by miRNA  nephron development  intracellular transport of virus  regulation of cellular response to heat  
Pathways : BIOCARTAProtein Kinase A at the Centrosome [Genes]   
NDEx NetworkNUP85
Atlas of Cancer Signalling NetworkNUP85
Wikipedia pathwaysNUP85
Orthology - Evolution
OrthoDB79902
GeneTree (enSembl)ENSG00000125450
Phylogenetic Trees/Animal Genes : TreeFamNUP85
HOGENOMQ9BW27
Homologs : HomoloGeneNUP85
Homology/Alignments : Family Browser (UCSC)NUP85
Gene fusions - Rearrangements
Fusion PortalNUP85 ZDHHC18
Fusion PortalNUP85 KCTD2
Fusion PortalPPM1D NUP85
Fusion PortalKIAA0195 NUP85
Fusion : QuiverNUP85
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNUP85 [hg38]
dbVarNUP85
ClinVarNUP85
MonarchNUP85
1000_GenomesNUP85 
Exome Variant ServerNUP85
GNOMAD BrowserENSG00000125450
Varsome BrowserNUP85
Genomic Variants (DGV)NUP85 [DGVbeta]
DECIPHERNUP85 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNUP85 
Mutations
ICGC Data PortalNUP85 
TCGA Data PortalNUP85 
Broad Tumor PortalNUP85
OASIS PortalNUP85 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNUP85  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNUP85
Mutations and Diseases : HGMDNUP85
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NUP85
DgiDB (Drug Gene Interaction Database)NUP85
DoCM (Curated mutations)NUP85 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NUP85 (select a term)
intoGenNUP85
Cancer3DNUP85(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM170285    618176   
Orphanet
DisGeNETNUP85
MedgenNUP85
Genetic Testing Registry NUP85
NextProtQ9BW27 [Medical]
GENETestsNUP85
Target ValidationNUP85
Huge Navigator NUP85 [HugePedia]
ClinGenNUP85
Clinical trials, drugs, therapy
MyCancerGenomeNUP85
Protein Interactions : CTD
Pharm GKB GenePA142671241
Clinical trialNUP85
Miscellaneous
canSAR (ICR)NUP85 (select the gene name)
HarmonizomeNUP85
DataMed IndexNUP85
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNUP85
EVEXNUP85
GoPubMedNUP85
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Dec 5 17:19:44 CET 2020

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