NUPR1 (nuclear protein 1, transcriptional regulator)

2003-06-01  

Identity

HGNC
LOCATION
16p11.2
LOCUSID
ALIAS
COM1,P8

Other Information

Locus ID:

NCBI: 26471
MIM: 614812
HGNC: 29990
Ensembl: ENSG00000176046

Variants:

dbSNP: 26471
ClinVar: 26471
TCGA: ENSG00000176046
COSMIC: NUPR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176046ENST00000324873O60356
ENSG00000176046ENST00000324873A0A024QZC4
ENSG00000176046ENST00000395641O60356
ENSG00000176046ENST00000567646H3BS92

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

References

Pubmed IDYearTitleCitations
225653102012Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.51
191536682009Emerging role of nuclear protein 1 (NUPR1) in cancer biology.43
275485212016A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution.42
228218592012Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer.29
186908482008NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress.28
119405912002The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter.26
228997992012Nupr1-aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death.25
164788042006Regulation of apoptosis by the p8/prothymosin alpha complex.24
201818282010Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.23
171166932007Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction.21

Citation

Dessen P

NUPR1 (nuclear protein 1, transcriptional regulator)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41627/nupr1