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NUTM1 (nuclear protein in testis)

Written2007-02Anna Collin
Department of Clinical Genetics, University Hospital, SE-221 85 Lund, Sweden

(Note : for Links provided by Atlas : click)


Alias (NCBI)C15orf55
HGNC Alias symbNUT
HGNC Alias namenuclear protein in testis
HGNC Previous nameC15orf55
HGNC Previous namechromosome 15 open reading frame 55
LocusID (NCBI) 256646
Atlas_Id 41595
Location 15q14  [Link to chromosome band 15q14]
Location_base_pair Starts at 34343315 and ends at 34357737 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping NUTM1.png]
Local_order (position 32425358-32437221 on the chromosome 15 genomic sequence).
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACIN1 (14q11.2)::NUTM1 (15q14)BRD3 (9q34.2)::NUTM1 (15q14)BRD4 (19p13.12)::NUTM1 (15q14)
BRD9 (5p15.33)::NUTM1 (15q14)CUX1 (7q22.1)::NUTM1 (15q14)IKZF1 (7p12.2)::NUTM1 (15q14)
NSD3 (8p11.23)::NUTM1 (15q14)NUTM1 (15q14)::BRD3 (9q34.2)NUTM1 (15q14)::BRD4 (19p13.12)


Description The gene consists of 7 exons that span approximately 12 kb of genomic DNA in the centromere-to-telomere orientation. The translation initiation codon and the stop codon are predicted to exon 1 and exon 7, respectively.
Transcription The corresponding "wildtype" mRNA transcript is 3.6 kb.


Description The open reading frame is predicted to encode an 1127 amino acid protein with an estimated molecular weight of 120 kDa.
Expression Northern blot analysis has indicated that the normal expression of the NUT gene is highly restricted to the testis. No investigations have yet been made at the protein level.
Localisation Nuclear.
Function Unknown.

Implicated in

Entity .
Prognosis Carcinoma with t(15;19) translocation is invariably fatal with a rapid clinical course when located to the midline thoracic, head and neck structures. One tumor, displaying the cytogenetic and molecular cytogenetic features of carcinoma with t(15;19) translocation, but located to the iliac bone has been reported successfully cured.
It has been suggested that a critical prognostic difference exists between BRD4-NUT/t(15;19) positive tumors and tumors where NUT is rearranged but fused to an as yet unknown partner.
Cytogenetics t(15;19)(q14;p13) [reported breakpoints: t(15;19)(q11-15;p13)].
Hybrid/Mutated Gene The t(15;19)(q14;p13) results in an BRD4-NUT chimeric gene where exon 10 of BRD4 is fused to exon 2 of NUT.
Abnormal Protein The BRD4-NUT fusion is composed of the N-terminal of BRD4 (amino acids 1-720 out of 1372) and almost the entire protein sequence of NUT (amino acids 6-1127). The N-terminal of BRD4 includes bromodomains 1 and 2 and other, less well characterized functional domains.
Oncogenesis It has been suggested that the oncogenic effect of the NUT-BRD4 fusion is caused not only by the abnormal regulation of NUT by BRD4 promoter elements but also by the consequent ectopic expression of NUT in non-germinal tissues.


Note The vast majority of reported breakpoints in carcinoma with t(15;19) translocation were assigned to band 19p13, the exception being the cytogenetic interpretation of a 19q13 breakpoint reported once. The reported breakpoints on chromosome 15 have varied (15q11-q15).


Midline carcinoma with t(15;19) and BRD4-NUT fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy.
Engleson J, Soller M, Panagopoulos I, Dahlén A, Dictor M, Jerkeman M
BMC cancer. 2006 ; 6 : page 69.
PMID 16542442
Midline carcinoma of children and young adults with NUT rearrangement.
French CA, Kutok JL, Faquin WC, Toretsky JA, Antonescu CR, Griffin CA, Nose V, Vargas SO, Moschovi M, Tzortzatou-Stathopoulou F, Miyoshi I, Perez-Atayde AR, Aster JC, Fletcher JA
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2004 ; 22 (20) : 4135-4139.
PMID 15483023
BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma.
French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA
Cancer research. 2003 ; 63 (2) : 304-307.
PMID 12543779
Intrathoracic carcinoma in an 11-year-old girl showing a translocation t(15;19).
Kees UR, Mulcahy MT, Willoughby ML
The American journal of pediatric hematology/oncology. 1991 ; 13 (4) : 459-464.
PMID 1785673
Carcinoma with t(15;19) translocation.
Marx A, French CA, Fletcher JA
Successful treatment of a child with t(15;19)-positive tumor.
Mertens F, Wiebe T, Adlercreutz C, Mandahl N, French CA
Pediatric blood & cancer. 2007 ; 49 (7) : 1015-1017.
PMID 16435379


This paper should be referenced as such :
Collin, A
NUT (nuclear protein in testis)
Atlas Genet Cytogenet Oncol Haematol. 2007;11(3):207-208.
Free journal version : [ pdf ]   [ DOI ]

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(7;15)(q22;q14) CUX1::NUTM1 a novel fusion
t(5;15)(p15;q14) BRD9::NUTM1
t(7;15)(p12;q14) IKZF1::NUTM1
t(14;15)(q11;q14) ACIN1::NUTM1
t(15;17)(q14;q24) BPTF::NUTM1

External links


HGNC (Hugo)NUTM1   29919
Entrez_Gene (NCBI)NUTM1    NUT midline carcinoma family member 1
AliasesC15orf55; FAM22H; NUT
GeneCards (Weizmann)NUTM1
Ensembl hg19 (Hinxton)ENSG00000184507 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184507 [Gene_View]  ENSG00000184507 [Sequence]  chr15:34343315-34357737 [Contig_View]  NUTM1 [Vega]
ICGC DataPortalENSG00000184507
TCGA cBioPortalNUTM1
Genatlas (Paris)NUTM1
SOURCE (Princeton)NUTM1
Genetics Home Reference (NIH)NUTM1
Genomic and cartography
GoldenPath hg38 (UCSC)NUTM1  -     chr15:34343315-34357737 +  15q14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NUTM1  -     15q14   [Description]    (hg19-Feb_2009)
GoldenPathNUTM1 - 15q14 [CytoView hg19]  NUTM1 - 15q14 [CytoView hg38]
Genome Data Viewer NCBINUTM1 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AF482429 AK098568 AK302656 AK302680 AL137416
RefSeq transcript (Entrez)NM_001284292 NM_001284293 NM_175741
Consensus coding sequences : CCDS (NCBI)NUTM1
Gene ExpressionNUTM1 [ NCBI-GEO ]   NUTM1 [ EBI - ARRAY_EXPRESS ]   NUTM1 [ SEEK ]   NUTM1 [ MEM ]
Gene Expression Viewer (FireBrowse)NUTM1 [ Firebrowse - Broad ]
GenevisibleExpression of NUTM1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)256646
GTEX Portal (Tissue expression)NUTM1
Human Protein AtlasENSG00000184507-NUTM1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86Y26   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86Y26  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86Y26
Domains : Interpro (EBI)NUT    NUT_N   
Domain families : Pfam (Sanger)NUT (PF12881)   
Domain families : Pfam (NCBI)pfam12881   
Conserved Domain (NCBI)NUTM1
AlphaFold pdb e-kbQ86Y26   
Human Protein Atlas [tissue]ENSG00000184507-NUTM1 [tissue]
Protein Interaction databases
IntAct (EBI)Q86Y26
Ontologies - Pathways
Ontology : AmiGOprotein binding  nucleus  cytoplasm  
Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  
NDEx NetworkNUTM1
Atlas of Cancer Signalling NetworkNUTM1
Wikipedia pathwaysNUTM1
Orthology - Evolution
GeneTree (enSembl)ENSG00000184507
Phylogenetic Trees/Animal Genes : TreeFamNUTM1
Homologs : HomoloGeneNUTM1
Homology/Alignments : Family Browser (UCSC)NUTM1
Gene fusions - Rearrangements
Fusion : MitelmanBRD3::NUTM1 [9q34.2/15q14]  
Fusion : MitelmanBRD4::NUTM1 [19p13.12/15q14]  
Fusion : COSMICBRD4 [19p13.12]  -  NUTM1 [15q14]  [fusion_780]  [fusion_821]  [fusion_972]  
Fusion : QuiverNUTM1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNUTM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NUTM1
Exome Variant ServerNUTM1
GNOMAD BrowserENSG00000184507
Varsome BrowserNUTM1
ACMGNUTM1 variants
Genomic Variants (DGV)NUTM1 [DGVbeta]
DECIPHERNUTM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNUTM1 
ICGC Data PortalNUTM1 
TCGA Data PortalNUTM1 
Broad Tumor PortalNUTM1
OASIS PortalNUTM1 [ Somatic mutations - Copy number]
Cancer Gene: CensusNUTM1 
Somatic Mutations in Cancer : COSMICNUTM1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNUTM1
Mutations and Diseases : HGMDNUTM1
intOGen PortalC15orf55
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
DgiDB (Drug Gene Interaction Database)NUTM1
DoCM (Curated mutations)NUTM1
CIViC (Clinical Interpretations of Variants in Cancer)NUTM1
NCG (London)NUTM1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry NUTM1
NextProtQ86Y26 [Medical]
Target ValidationNUTM1
Huge Navigator NUTM1 [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTDNUTM1
Pharm GKB GenePA162378206
Clinical trialNUTM1
DataMed IndexNUTM1
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Oct 8 21:24:12 CEST 2021

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