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NVL (nuclear VCP like)

Identity

Alias (NCBI)NVL2
HGNC (Hugo) NVL
HGNC Alias symbNVL2
HGNC Alias nameNuclear valosin-containing protein-like
 nuclear VCP-like protein
LocusID (NCBI) 4931
Atlas_Id 46210
Location 1q42.11  [Link to chromosome band 1q42]
Location_base_pair Starts at 224227334 and ends at 224330189 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ELMSAN1 (14q24.3) / NVL (1q42.11)FASTKD2 (2q33.3) / NVL (1q42.11)NVL (1q42.11) / FMN2 (1q43)
NVL (1q42.11) / NEK2 (1q32.3)NVL (1q42.11) / RPL8 (8q24.3)PIK3CB (3q22.3) / NVL (1q42.11)
SUSD4 (1q41) / NVL (1q42.11)NVL 1q42.11 / NEK2 1q32.3SUSD4 1q41 / NVL 1q42.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(q42;q43) NVL/FMN2


External links

 

Nomenclature
HGNC (Hugo)NVL   8070
Cards
Entrez_Gene (NCBI)NVL    nuclear VCP like
AliasesNVL2
GeneCards (Weizmann)NVL
Ensembl hg19 (Hinxton)ENSG00000143748 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143748 [Gene_View]  ENSG00000143748 [Sequence]  chr1:224227334-224330189 [Contig_View]  NVL [Vega]
ICGC DataPortalENSG00000143748
TCGA cBioPortalNVL
AceView (NCBI)NVL
Genatlas (Paris)NVL
SOURCE (Princeton)NVL
Genetics Home Reference (NIH)NVL
Genomic and cartography
GoldenPath hg38 (UCSC)NVL  -     chr1:224227334-224330189 -  1q42.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NVL  -     1q42.11   [Description]    (hg19-Feb_2009)
GoldenPathNVL - 1q42.11 [CytoView hg19]  NVL - 1q42.11 [CytoView hg38]
ImmunoBaseENSG00000143748
Genome Data Viewer NCBINVL [Mapview hg19]  
OMIM602426   
Gene and transcription
Genbank (Entrez)AF401208 AK293923 AK297070 AK297396 AK298244
RefSeq transcript (Entrez)NM_001243146 NM_001243147 NM_002533 NM_206840
Consensus coding sequences : CCDS (NCBI)NVL
Gene ExpressionNVL [ NCBI-GEO ]   NVL [ EBI - ARRAY_EXPRESS ]   NVL [ SEEK ]   NVL [ MEM ]
Gene Expression Viewer (FireBrowse)NVL [ Firebrowse - Broad ]
GenevisibleExpression of NVL in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4931
GTEX Portal (Tissue expression)NVL
Human Protein AtlasENSG00000143748-NVL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15381   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15381  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15381
PhosPhoSitePlusO15381
Domaine pattern : Prosite (Expaxy)AAA (PS00674)   
Domains : Interpro (EBI)AAA+_ATPase    AAA_lid_3    ATPase_AAA_core    ATPase_AAA_CS    NLV2_N_sf    NVL2_nucleolin-bd    P-loop_NTPase   
Domain families : Pfam (Sanger)AAA (PF00004)    AAA_lid_3 (PF17862)    Nucleolin_bd (PF16725)   
Domain families : Pfam (NCBI)pfam00004    pfam17862    pfam16725   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)NVL
PDB (RSDB)2X8A    6RO1   
PDB Europe2X8A    6RO1   
PDB (PDBSum)2X8A    6RO1   
PDB (IMB)2X8A    6RO1   
Structural Biology KnowledgeBase2X8A    6RO1   
SCOP (Structural Classification of Proteins)2X8A    6RO1   
CATH (Classification of proteins structures)2X8A    6RO1   
SuperfamilyO15381
AlphaFold pdb e-kbO15381   
Human Protein Atlas [tissue]ENSG00000143748-NVL [tissue]
HPRD03887
Protein Interaction databases
DIP (DOE-UCLA)O15381
IntAct (EBI)O15381
BioGRIDNVL
STRING (EMBL)NVL
ZODIACNVL
Ontologies - Pathways
QuickGOO15381
Ontology : AmiGORNA binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  telomerase holoenzyme complex  nucleolus  nucleolus  rRNA processing  membrane  ATPase  positive regulation of protein binding  ribosome biogenesis  ribosome biogenesis  ribosomal large subunit biogenesis  ribosomal large subunit biogenesis  positive regulation of telomerase activity  positive regulation of telomerase activity  regulation of protein localization to nucleolus  preribosome binding  preribosome binding  
Ontology : EGO-EBIRNA binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  telomerase holoenzyme complex  nucleolus  nucleolus  rRNA processing  membrane  ATPase  positive regulation of protein binding  ribosome biogenesis  ribosome biogenesis  ribosomal large subunit biogenesis  ribosomal large subunit biogenesis  positive regulation of telomerase activity  positive regulation of telomerase activity  regulation of protein localization to nucleolus  preribosome binding  preribosome binding  
Pathways : KEGGRibosome biogenesis in eukaryotes   
NDEx NetworkNVL
Atlas of Cancer Signalling NetworkNVL
Wikipedia pathwaysNVL
Orthology - Evolution
OrthoDB4931
GeneTree (enSembl)ENSG00000143748
Phylogenetic Trees/Animal Genes : TreeFamNVL
Homologs : HomoloGeneNVL
Homology/Alignments : Family Browser (UCSC)NVL
Gene fusions - Rearrangements
Fusion : MitelmanNVL/FMN2 [1q42.11/1q43]  
Fusion : MitelmanNVL/NEK2 [1q42.11/1q32.3]  
Fusion : MitelmanSUSD4/NVL [1q41/1q42.11]  
Fusion : QuiverNVL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNVL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NVL
dbVarNVL
ClinVarNVL
MonarchNVL
1000_GenomesNVL 
Exome Variant ServerNVL
GNOMAD BrowserENSG00000143748
Varsome BrowserNVL
ACMGNVL variants
VarityO15381
Genomic Variants (DGV)NVL [DGVbeta]
DECIPHERNVL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNVL 
Mutations
ICGC Data PortalNVL 
TCGA Data PortalNVL 
Broad Tumor PortalNVL
OASIS PortalNVL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNVL  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNVL
Mutations and Diseases : HGMDNVL
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNVL
DgiDB (Drug Gene Interaction Database)NVL
DoCM (Curated mutations)NVL
CIViC (Clinical Interpretations of Variants in Cancer)NVL
Cancer3DNVL
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602426   
Orphanet
DisGeNETNVL
MedgenNVL
Genetic Testing Registry NVL
NextProtO15381 [Medical]
GENETestsNVL
Target ValidationNVL
Huge Navigator NVL [HugePedia]
ClinGenNVL
Clinical trials, drugs, therapy
MyCancerGenomeNVL
Protein Interactions : CTDNVL
Pharm GKB GenePA31857
PharosO15381
Clinical trialNVL
Miscellaneous
canSAR (ICR)NVL
HarmonizomeNVL
DataMed IndexNVL
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNVL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:23:35 CEST 2021

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