NXF1 (nuclear RNA export factor 1)

2007-04-01  

Identity

HGNC
LOCATION
11q12.3
LOCUSID
ALIAS
MEX67,TAP
FUSION GENES

Other Information

Locus ID:

NCBI: 10482
MIM: 602647
HGNC: 8071
Ensembl: ENSG00000162231

Variants:

dbSNP: 10482
ClinVar: 10482
TCGA: ENSG00000162231
COSMIC: NXF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162231ENST00000294172Q9UBU9
ENSG00000162231ENST00000525576E9PQA4
ENSG00000162231ENST00000527902H0YDU0
ENSG00000162231ENST00000530875E9PIN3
ENSG00000162231ENST00000531131B4E227
ENSG00000162231ENST00000531474E9PMV7
ENSG00000162231ENST00000531709Q9UBU9
ENSG00000162231ENST00000532297Q9UBU9
ENSG00000162231ENST00000533671E9PLA7

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Ribosome biogenesis in eukaryotesKEGGko03008
Ribosome biogenesis in eukaryotesKEGGhsa03008
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236
Transport of Mature mRNAs Derived from Intronless TranscriptsREACTOMER-HSA-159234
Transport of the SLBP Dependant Mature mRNAREACTOMER-HSA-159230
Transport of the SLBP independent Mature mRNAREACTOMER-HSA-159227
Transport of Mature mRNA Derived from an Intronless TranscriptREACTOMER-HSA-159231

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
152109562004A molecular link between SR protein dephosphorylation and mRNA export.109
228931302012TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export.71
169719482006An intron with a constitutive transport element is retained in a Tap messenger RNA.66
157673972005ICP27 recruits Aly/REF but not TAP/NXF1 to herpes simplex virus type 1 transcription sites although TAP/NXF1 is required for ICP27 export.63
151843802004Hypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteins.52
200714842010Individual influenza A virus mRNAs show differential dependence on cellular NXF1/TAP for their nuclear export.45
176092852007Kaposi's sarcoma-associated herpesvirus ORF57 protein enhances mRNA accumulation independently of effects on nuclear RNA export.44
193693542009The cellular RNA export receptor TAP/NXF1 is required for ICP27-mediated export of herpes simplex virus 1 RNA, but the TREX complex adaptor protein Aly/REF appears to be dispensable.35
125816452003Structural basis for the interaction between the Tap/NXF1 UBA domain and FG nucleoporins at 1A resolution.34
190199562009Efficient nuclear export of herpes simplex virus 1 transcripts requires both RNA binding by ICP27 and ICP27 interaction with TAP/NXF1.33

Citation

Dessen P

NXF1 (nuclear RNA export factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46831/nxf1