Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

NXN (nucleoredoxin)

Identity

Alias_symbol (synonym)FLJ12614
NRX
Other aliasTRG-4
HGNC (Hugo) NXN
LocusID (NCBI) 64359
Atlas_Id 71064
Location 17p13.3  [Link to chromosome band 17p13]
Location_base_pair Starts at 799313 and ends at 864111 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ABR (17p13.3) / NXN (17p13.3)MAPK8IP3 (16p13.3) / NXN (17p13.3)NISCH (3p21.1) / NXN (17p13.3)
NXN (17p13.3) / ABR (17p13.3)NXN (17p13.3) / CA10 (17q21.33)NXN (17p13.3) / GLOD4 (17p13.3)
NXN (17p13.3) / ID3 (1p36.12)NXN (17p13.3) / INO80 (15q15.1)NXN (17p13.3) / NXN (17p13.3)
NXN (17p13.3) / RBL2 (16q12.2)NXN (17p13.3) / WRAP53 (17p13.1)PPARGC1A (4p15.2) / NXN (17p13.3)
RHBDL2 (1p34.3) / NXN (17p13.3)SMG6 (17p13.3) / NXN (17p13.3)NXN WRAP53
NXN ABR

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NXN   18008
Cards
Entrez_Gene (NCBI)NXN  64359  nucleoredoxin
AliasesNRX; TRG-4
GeneCards (Weizmann)NXN
Ensembl hg19 (Hinxton)ENSG00000167693 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167693 [Gene_View]  chr17:799313-864111 [Contig_View]  NXN [Vega]
ICGC DataPortalENSG00000167693
TCGA cBioPortalNXN
AceView (NCBI)NXN
Genatlas (Paris)NXN
WikiGenes64359
SOURCE (Princeton)NXN
Genetics Home Reference (NIH)NXN
Genomic and cartography
GoldenPath hg38 (UCSC)NXN  -     chr17:799313-864111 -  17p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NXN  -     17p13.3   [Description]    (hg19-Feb_2009)
EnsemblNXN - 17p13.3 [CytoView hg19]  NXN - 17p13.3 [CytoView hg38]
Mapping of homologs : NCBINXN [Mapview hg19]  NXN [Mapview hg38]
OMIM612895   
Gene and transcription
Genbank (Entrez)AF086523 AK022676 AK027451 AK297990 AK302073
RefSeq transcript (Entrez)NM_001205319 NM_022463
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_187613 NT_187664
Consensus coding sequences : CCDS (NCBI)NXN
Cluster EST : UnigeneHs.527989 [ NCBI ]
CGAP (NCI)Hs.527989
Alternative Splicing GalleryENSG00000167693
Gene ExpressionNXN [ NCBI-GEO ]   NXN [ EBI - ARRAY_EXPRESS ]   NXN [ SEEK ]   NXN [ MEM ]
Gene Expression Viewer (FireBrowse)NXN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64359
GTEX Portal (Tissue expression)NXN
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6DKJ4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6DKJ4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6DKJ4
Splice isoforms : SwissVarQ6DKJ4
PhosPhoSitePlusQ6DKJ4
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)Thioredoxin-like_fold    Thioredoxin_domain   
Domain families : Pfam (Sanger)Thioredoxin_8 (PF13905)   
Domain families : Pfam (NCBI)pfam13905   
Conserved Domain (NCBI)NXN
DMDM Disease mutations64359
Blocks (Seattle)NXN
SuperfamilyQ6DKJ4
Human Protein AtlasENSG00000167693
Peptide AtlasQ6DKJ4
HPRD14858
IPIIPI00304267   IPI00651743   IPI00908739   IPI00555881   IPI01013498   
Protein Interaction databases
DIP (DOE-UCLA)Q6DKJ4
IntAct (EBI)Q6DKJ4
FunCoupENSG00000167693
BioGRIDNXN
STRING (EMBL)NXN
ZODIACNXN
Ontologies - Pathways
QuickGOQ6DKJ4
Ontology : AmiGOthioredoxin-disulfide reductase activity  nucleus  cytoplasm  cytosol  Wnt signaling pathway  cell differentiation  negative regulation of Wnt signaling pathway  negative regulation of protein ubiquitination  cell redox homeostasis  protein-disulfide reductase activity  oxidation-reduction process  cardiovascular system development  cellular oxidant detoxification  
Ontology : EGO-EBIthioredoxin-disulfide reductase activity  nucleus  cytoplasm  cytosol  Wnt signaling pathway  cell differentiation  negative regulation of Wnt signaling pathway  negative regulation of protein ubiquitination  cell redox homeostasis  protein-disulfide reductase activity  oxidation-reduction process  cardiovascular system development  cellular oxidant detoxification  
NDEx NetworkNXN
Atlas of Cancer Signalling NetworkNXN
Wikipedia pathwaysNXN
Orthology - Evolution
OrthoDB64359
GeneTree (enSembl)ENSG00000167693
Phylogenetic Trees/Animal Genes : TreeFamNXN
HOVERGENQ6DKJ4
HOGENOMQ6DKJ4
Homologs : HomoloGeneNXN
Homology/Alignments : Family Browser (UCSC)NXN
Gene fusions - Rearrangements
Fusion: TCGANXN WRAP53
Fusion: TCGANXN ABR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNXN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NXN
dbVarNXN
ClinVarNXN
1000_GenomesNXN 
Exome Variant ServerNXN
ExAC (Exome Aggregation Consortium)NXN (select the gene name)
Genetic variants : HAPMAP64359
Genomic Variants (DGV)NXN [DGVbeta]
DECIPHERNXN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNXN 
Mutations
ICGC Data PortalNXN 
TCGA Data PortalNXN 
Broad Tumor PortalNXN
OASIS PortalNXN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNXN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNXN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NXN
DgiDB (Drug Gene Interaction Database)NXN
DoCM (Curated mutations)NXN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NXN (select a term)
intoGenNXN
Cancer3DNXN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612895   
Orphanet
MedgenNXN
Genetic Testing Registry NXN
NextProtQ6DKJ4 [Medical]
TSGene64359
GENETestsNXN
Target ValidationNXN
Huge Navigator NXN [HugePedia]
snp3D : Map Gene to Disease64359
BioCentury BCIQNXN
ClinGenNXN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64359
Chemical/Pharm GKB GenePA31863
Clinical trialNXN
Miscellaneous
canSAR (ICR)NXN (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNXN
EVEXNXN
GoPubMedNXN
iHOPNXN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 31 15:33:23 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.