OAS1 (2-5-oligoadenylate synthetase 1)

2003-11-01  

Identity

HGNC
LOCATION
12q24.13
LOCUSID
ALIAS
E18/E16,IFI-4,OIAS,OIASI
FUSION GENES

Other Information

Locus ID:

NCBI: 4938
MIM: 164350
HGNC: 8086
Ensembl: ENSG00000089127

Variants:

dbSNP: 4938
ClinVar: 4938
TCGA: ENSG00000089127
COSMIC: OAS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089127ENST00000202917P00973
ENSG00000089127ENST00000540589S4R3A5
ENSG00000089127ENST00000550689H0YI20
ENSG00000089127ENST00000550883F8VPW7
ENSG00000089127ENST00000551241F8VXY3
ENSG00000089127ENST00000552526C6EMZ7
ENSG00000089127ENST00000553152H0YIB8
ENSG00000089127ENST00000553185F8VUC8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192474382009Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man.93
192474382009Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man.93
230117992012ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6.70
129449782003Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR.68
129449782003Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR.68
157320092005Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene.57
233196252013Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1.57
157665582005Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population.47
157665582005Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population.47
162351722005Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.46

Citation

Dessen P

OAS1 (2-5-oligoadenylate synthetase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41600/oas1