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OAS1 (2'-5'-oligoadenylate synthetase 1, 40/46kDa)

Identity

Other namesIFI-4
OIAS
OIASI
HGNC (Hugo) OAS1
LocusID (NCBI) 4938
Location 12q24.13
Location_base_pair Starts at 113344739 and ends at 113357712 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)OAS1   8086
Cards
Entrez_Gene (NCBI)OAS1  4938  2'-5'-oligoadenylate synthetase 1, 40/46kDa
GeneCards (Weizmann)OAS1
Ensembl (Hinxton)ENSG00000089127 [Gene_View]  chr12:113344739-113357712 [Contig_View]  OAS1 [Vega]
ICGC DataPortalENSG00000089127
cBioPortalOAS1
AceView (NCBI)OAS1
Genatlas (Paris)OAS1
WikiGenes4938
SOURCE (Princeton)NM_001032409 NM_002534 NM_016816
Genomic and cartography
GoldenPath (UCSC)OAS1  -  12q24.13   chr12:113344739-113357712 +  12q24.13   [Description]    (hg19-Feb_2009)
EnsemblOAS1 - 12q24.13 [CytoView]
Mapping of homologs : NCBIOAS1 [Mapview]
OMIM164350   222100   
Gene and transcription
Genbank (Entrez)AJ629455 AK123528 AK223006 AK225384 AK291003
RefSeq transcript (Entrez)NM_001032409 NM_002534 NM_016816
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NG_011530 NT_029419 NW_001838063 NW_004929385
Consensus coding sequences : CCDS (NCBI)OAS1
Cluster EST : UnigeneHs.524760 [ NCBI ]
CGAP (NCI)Hs.524760
Alternative Splicing : Fast-db (Paris)GSHG0007017
Alternative Splicing GalleryENSG00000089127
Gene ExpressionOAS1 [ NCBI-GEO ]     OAS1 [ SEEK ]   OAS1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00973 (Uniprot)
NextProtP00973  [Medical]
With graphics : InterProP00973
Splice isoforms : SwissVarP00973 (Swissvar)
Catalytic activity : Enzyme2.7.7.84 [ Enzyme-Expasy ]   2.7.7.842.7.7.84 [ IntEnz-EBI ]   2.7.7.84 [ BRENDA ]   2.7.7.84 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)25A_SYNTH_1 (PS00832)    25A_SYNTH_2 (PS00833)    25A_SYNTH_3 (PS50152)   
Domains : Interpro (EBI)2-5-oligoadenylate_synth_CS [organisation]   2-5-oligoadenylate_synth_N [organisation]   2-5-oligoAdlate_synth_1_dom2/C [organisation]   2-5A_synthase [organisation]   Nucleotidyltransferase [organisation]  
Related proteins : CluSTrP00973
Domain families : Pfam (Sanger)NTP_transf_2 (PF01909)    OAS1_C (PF10421)   
Domain families : Pfam (NCBI)pfam01909    pfam10421   
DMDM Disease mutations4938
Blocks (Seattle)P00973
PDB (SRS)4IG8   
PDB (PDBSum)4IG8   
PDB (IMB)4IG8   
PDB (RSDB)4IG8   
Human Protein AtlasENSG00000089127 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP00973
HPRD08879
IPIIPI00305585   IPI00513823   IPI00220806   IPI00790698   IPI01022468   IPI00979938   IPI00651622   IPI01022644   IPI01022927   IPI01021619   IPI01022063   IPI01021905   
Protein Interaction databases
DIP (DOE-UCLA)P00973
IntAct (EBI)P00973
FunCoupENSG00000089127
BioGRIDOAS1
InParanoidP00973
Interologous Interaction database P00973
IntegromeDBOAS1
STRING (EMBL)OAS1
Ontologies - Pathways
Ontology : AmiGO2'-5'-oligoadenylate synthetase activity  double-stranded RNA binding  protein binding  ATP binding  extracellular region  nucleus  nucleus  cytoplasm  mitochondrion  endoplasmic reticulum  cytosol  glucose metabolic process  purine nucleotide biosynthetic process  zinc ion binding  response to virus  cytokine-mediated signaling pathway  cellular response to interferon-alpha  glucose homeostasis  negative regulation of viral genome replication  metal ion binding  protein oligomerization  defense response to virus  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  regulation of ribonuclease activity  
Ontology : EGO-EBI2'-5'-oligoadenylate synthetase activity  double-stranded RNA binding  protein binding  ATP binding  extracellular region  nucleus  nucleus  cytoplasm  mitochondrion  endoplasmic reticulum  cytosol  glucose metabolic process  purine nucleotide biosynthetic process  zinc ion binding  response to virus  cytokine-mediated signaling pathway  cellular response to interferon-alpha  glucose homeostasis  negative regulation of viral genome replication  metal ion binding  protein oligomerization  defense response to virus  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  regulation of ribonuclease activity  
Pathways : KEGGHepatitis C    Measles    Influenza A    Herpes simplex infection   
Protein Interaction DatabaseOAS1
Wikipedia pathwaysOAS1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)OAS1
snp3D : Map Gene to Disease4938
SNP (GeneSNP Utah)OAS1
SNP : HGBaseOAS1
Genetic variants : HAPMAPOAS1
Exome VariantOAS1
1000_GenomesOAS1 
ICGC programENSG00000089127 
Somatic Mutations in Cancer : COSMICOAS1 
CONAN: Copy Number AnalysisOAS1 
Mutations and Diseases : HGMDOAS1
Mutations and Diseases : intOGenOAS1
Genomic VariantsOAS1  OAS1 [DGVbeta]
dbVarOAS1
ClinVarOAS1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM164350    222100   
MedgenOAS1
GENETestsOAS1
Disease Genetic AssociationOAS1
Huge Navigator OAS1 [HugePedia]  OAS1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneOAS1
Homology/Alignments : Family Browser (UCSC)OAS1
Phylogenetic Trees/Animal Genes : TreeFamOAS1
Chemical/Protein Interactions : CTD4938
Chemical/Pharm GKB GenePA31875
Clinical trialOAS1
Cancer Resource (Charite)ENSG00000089127
Other databases
Probes
Litterature
PubMed78 Pubmed reference(s) in Entrez
CoreMineOAS1
iHOPOAS1
OncoSearchOAS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:58:21 CEST 2014

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