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OAS1 (2'-5'-oligoadenylate synthetase 1)

Identity

Other namesE18/E16
IFI-4
OIAS
OIASI
HGNC (Hugo) OAS1
LocusID (NCBI) 4938
Atlas_Id 41600
Location 12q24.13
Location_base_pair Starts at 113344582 and ends at 113357712 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
OAS1 (12q24.13) / CYR61 (1p22.3)OAS1 (12q24.13) / OAS1 (12q24.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OAS1   8086
Cards
Entrez_Gene (NCBI)OAS1  4938  2'-5'-oligoadenylate synthetase 1
AliasesE18/E16; IFI-4; OIAS; OIASI
GeneCards (Weizmann)OAS1
Ensembl hg19 (Hinxton)ENSG00000089127 [Gene_View]  chr12:113344582-113357712 [Contig_View]  OAS1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000089127 [Gene_View]  chr12:113344582-113357712 [Contig_View]  OAS1 [Vega]
ICGC DataPortalENSG00000089127
TCGA cBioPortalOAS1
AceView (NCBI)OAS1
Genatlas (Paris)OAS1
WikiGenes4938
SOURCE (Princeton)OAS1
Genomic and cartography
GoldenPath hg19 (UCSC)OAS1  -     chr12:113344582-113357712 +  12q24.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)OAS1  -     12q24.13   [Description]    (hg38-Dec_2013)
EnsemblOAS1 - 12q24.13 [CytoView hg19]  OAS1 - 12q24.13 [CytoView hg38]
Mapping of homologs : NCBIOAS1 [Mapview hg19]  OAS1 [Mapview hg38]
OMIM164350   222100   
Gene and transcription
Genbank (Entrez)AA085948 AJ629455 AK123528 AK223006 AK225384
RefSeq transcript (Entrez)NM_001032409 NM_001320151 NM_002534 NM_016816
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_011530 NT_029419 NW_004929385
Consensus coding sequences : CCDS (NCBI)OAS1
Cluster EST : UnigeneHs.524760 [ NCBI ]
CGAP (NCI)Hs.524760
Alternative Splicing GalleryENSG00000089127
Gene ExpressionOAS1 [ NCBI-GEO ]   OAS1 [ EBI - ARRAY_EXPRESS ]   OAS1 [ SEEK ]   OAS1 [ MEM ]
Gene Expression Viewer (FireBrowse)OAS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4938
GTEX Portal (Tissue expression)OAS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00973 (Uniprot)
NextProtP00973  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP00973
Splice isoforms : SwissVarP00973 (Swissvar)
Catalytic activity : Enzyme2.7.7.84 [ Enzyme-Expasy ]   2.7.7.842.7.7.84 [ IntEnz-EBI ]   2.7.7.84 [ BRENDA ]   2.7.7.84 [ KEGG ]   
PhosPhoSitePlusP00973
Domaine pattern : Prosite (Expaxy)25A_SYNTH_1 (PS00832)    25A_SYNTH_2 (PS00833)    25A_SYNTH_3 (PS50152)   
Domains : Interpro (EBI)2-5-oligoadenylate_synth_CS    2-5-oligoadenylate_synth_N    2-5-oligoAdlate_synth_1_dom2/C    2-5A_synthase    Polymerase_NTP_transf_dom   
Domain families : Pfam (Sanger)NTP_transf_2 (PF01909)    OAS1_C (PF10421)   
Domain families : Pfam (NCBI)pfam01909    pfam10421   
DMDM Disease mutations4938
Blocks (Seattle)OAS1
PDB (SRS)4IG8   
PDB (PDBSum)4IG8   
PDB (IMB)4IG8   
PDB (RSDB)4IG8   
Structural Biology KnowledgeBase4IG8   
SCOP (Structural Classification of Proteins)4IG8   
CATH (Classification of proteins structures)4IG8   
SuperfamilyP00973
Human Protein AtlasENSG00000089127
Peptide AtlasP00973
HPRD08879
IPIIPI00305585   IPI00513823   IPI00220806   IPI00790698   IPI01022468   IPI00979938   IPI00651622   IPI01022644   IPI01022927   IPI01021619   IPI01022063   IPI01021905   
Protein Interaction databases
DIP (DOE-UCLA)P00973
IntAct (EBI)P00973
FunCoupENSG00000089127
BioGRIDOAS1
STRING (EMBL)OAS1
ZODIACOAS1
Ontologies - Pathways
QuickGOP00973
Ontology : AmiGO2'-5'-oligoadenylate synthetase activity  double-stranded RNA binding  protein binding  ATP binding  extracellular region  nucleus  nucleus  cytoplasm  mitochondrion  endoplasmic reticulum  cytosol  glucose metabolic process  purine nucleotide biosynthetic process  zinc ion binding  response to virus  cellular response to interferon-alpha  glucose homeostasis  negative regulation of viral genome replication  metal ion binding  protein oligomerization  defense response to virus  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  regulation of ribonuclease activity  
Ontology : EGO-EBI2'-5'-oligoadenylate synthetase activity  double-stranded RNA binding  protein binding  ATP binding  extracellular region  nucleus  nucleus  cytoplasm  mitochondrion  endoplasmic reticulum  cytosol  glucose metabolic process  purine nucleotide biosynthetic process  zinc ion binding  response to virus  cellular response to interferon-alpha  glucose homeostasis  negative regulation of viral genome replication  metal ion binding  protein oligomerization  defense response to virus  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  regulation of ribonuclease activity  
Pathways : KEGGHepatitis C    Measles    Influenza A    Herpes simplex infection   
NDEx Network
Atlas of Cancer Signalling NetworkOAS1
Wikipedia pathwaysOAS1
Orthology - Evolution
OrthoDB4938
GeneTree (enSembl)ENSG00000089127
Phylogenetic Trees/Animal Genes : TreeFamOAS1
Homologs : HomoloGeneOAS1
Homology/Alignments : Family Browser (UCSC)OAS1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerOAS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OAS1
dbVarOAS1
ClinVarOAS1
1000_GenomesOAS1 
Exome Variant ServerOAS1
ExAC (Exome Aggregation Consortium)OAS1 (select the gene name)
Genetic variants : HAPMAP4938
Genomic Variants (DGV)OAS1 [DGVbeta]
Mutations
ICGC Data PortalOAS1 
TCGA Data PortalOAS1 
Broad Tumor PortalOAS1
OASIS PortalOAS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOAS1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch OAS1
DgiDB (Drug Gene Interaction Database)OAS1
DoCM (Curated mutations)OAS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OAS1 (select a term)
intoGenOAS1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:113344582-113357712  ENSG00000089127
CONAN: Copy Number AnalysisOAS1 
Mutations and Diseases : HGMDOAS1
OMIM164350    222100   
MedgenOAS1
Genetic Testing Registry OAS1
NextProtP00973 [Medical]
TSGene4938
GENETestsOAS1
Huge Navigator OAS1 [HugePedia]
snp3D : Map Gene to Disease4938
BioCentury BCIQOAS1
ClinGenOAS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4938
Chemical/Pharm GKB GenePA31875
Clinical trialOAS1
Miscellaneous
canSAR (ICR)OAS1 (select the gene name)
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOAS1
EVEXOAS1
GoPubMedOAS1
iHOPOAS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:14:23 CEST 2016

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