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OAS2 (2'-5'-oligoadenylate synthetase 2)

Identity

Alias_names2'-5'-oligoadenylate synthetase 2 (69-71 kD)
2'-5'-oligoadenylate synthetase 2, 69/71kDa
Other alias-
HGNC (Hugo) OAS2
LocusID (NCBI) 4939
Atlas_Id 55798
Location 12q24.13  [Link to chromosome band 12q24]
Location_base_pair Starts at 113416274 and ends at 113426610 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BTBD2 (19p13.3) / OAS2 (12q24.13)OAS2 (12q24.13) / HECTD4 (12q24.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OAS2   8087
Cards
Entrez_Gene (NCBI)OAS2  4939  2'-5'-oligoadenylate synthetase 2
Aliases
GeneCards (Weizmann)OAS2
Ensembl hg19 (Hinxton)ENSG00000111335 [Gene_View]  chr12:113416274-113426610 [Contig_View]  OAS2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000111335 [Gene_View]  chr12:113416274-113426610 [Contig_View]  OAS2 [Vega]
ICGC DataPortalENSG00000111335
TCGA cBioPortalOAS2
AceView (NCBI)OAS2
Genatlas (Paris)OAS2
WikiGenes4939
SOURCE (Princeton)OAS2
Genetics Home Reference (NIH)OAS2
Genomic and cartography
GoldenPath hg19 (UCSC)OAS2  -     chr12:113416274-113426610 +  12q24.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)OAS2  -     12q24.13   [Description]    (hg38-Dec_2013)
EnsemblOAS2 - 12q24.13 [CytoView hg19]  OAS2 - 12q24.13 [CytoView hg38]
Mapping of homologs : NCBIOAS2 [Mapview hg19]  OAS2 [Mapview hg38]
OMIM603350   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_001032731 NM_002535 NM_016817
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OAS2
Cluster EST : UnigeneHs.414332 [ NCBI ]
CGAP (NCI)Hs.414332
Alternative Splicing GalleryENSG00000111335
Gene ExpressionOAS2 [ NCBI-GEO ]   OAS2 [ EBI - ARRAY_EXPRESS ]   OAS2 [ SEEK ]   OAS2 [ MEM ]
Gene Expression Viewer (FireBrowse)OAS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4939
GTEX Portal (Tissue expression)OAS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29728   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP29728  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29728
Splice isoforms : SwissVarP29728
Catalytic activity : Enzyme2.7.7.84 [ Enzyme-Expasy ]   2.7.7.842.7.7.84 [ IntEnz-EBI ]   2.7.7.84 [ BRENDA ]   2.7.7.84 [ KEGG ]   
PhosPhoSitePlusP29728
Domaine pattern : Prosite (Expaxy)25A_SYNTH_1 (PS00832)    25A_SYNTH_2 (PS00833)    25A_SYNTH_3 (PS50152)   
Domains : Interpro (EBI)2-5-oligoadenylate_synth_CS    2-5-oligoadenylate_synth_N    2-5-oligoAdlate_synth_1_dom2/C    2-5A_synthase    Polymerase_NTP_transf_dom   
Domain families : Pfam (Sanger)NTP_transf_2 (PF01909)    OAS1_C (PF10421)   
Domain families : Pfam (NCBI)pfam01909    pfam10421   
Conserved Domain (NCBI)OAS2
DMDM Disease mutations4939
Blocks (Seattle)OAS2
SuperfamilyP29728
Human Protein AtlasENSG00000111335
Peptide AtlasP29728
HPRD04518
IPIIPI00217049   IPI00218185   IPI01021468   IPI01021348   IPI00448843   IPI00883624   
Protein Interaction databases
DIP (DOE-UCLA)P29728
IntAct (EBI)P29728
FunCoupENSG00000111335
BioGRIDOAS2
STRING (EMBL)OAS2
ZODIACOAS2
Ontologies - Pathways
QuickGOP29728
Ontology : AmiGO2'-5'-oligoadenylate synthetase activity  2'-5'-oligoadenylate synthetase activity  double-stranded RNA binding  double-stranded RNA binding  protein binding  ATP binding  nucleus  cytoplasm  mitochondrion  endoplasmic reticulum  cytosol  nucleobase-containing compound metabolic process  purine nucleotide biosynthetic process  RNA catabolic process  protein glycosylation  zinc ion binding  response to virus  membrane  protein myristoylation  intracellular membrane-bounded organelle  metal ion binding  perinuclear region of cytoplasm  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  
Ontology : EGO-EBI2'-5'-oligoadenylate synthetase activity  2'-5'-oligoadenylate synthetase activity  double-stranded RNA binding  double-stranded RNA binding  protein binding  ATP binding  nucleus  cytoplasm  mitochondrion  endoplasmic reticulum  cytosol  nucleobase-containing compound metabolic process  purine nucleotide biosynthetic process  RNA catabolic process  protein glycosylation  zinc ion binding  response to virus  membrane  protein myristoylation  intracellular membrane-bounded organelle  metal ion binding  perinuclear region of cytoplasm  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  
Pathways : KEGGHepatitis C    Measles    Influenza A    Herpes simplex infection   
NDEx NetworkOAS2
Atlas of Cancer Signalling NetworkOAS2
Wikipedia pathwaysOAS2
Orthology - Evolution
OrthoDB4939
GeneTree (enSembl)ENSG00000111335
Phylogenetic Trees/Animal Genes : TreeFamOAS2
HOVERGENP29728
HOGENOMP29728
Homologs : HomoloGeneOAS2
Homology/Alignments : Family Browser (UCSC)OAS2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOAS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OAS2
dbVarOAS2
ClinVarOAS2
1000_GenomesOAS2 
Exome Variant ServerOAS2
ExAC (Exome Aggregation Consortium)OAS2 (select the gene name)
Genetic variants : HAPMAP4939
Genomic Variants (DGV)OAS2 [DGVbeta]
DECIPHER (Syndromes)12:113416274-113426610  ENSG00000111335
CONAN: Copy Number AnalysisOAS2 
Mutations
ICGC Data PortalOAS2 
TCGA Data PortalOAS2 
Broad Tumor PortalOAS2
OASIS PortalOAS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOAS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOAS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OAS2
DgiDB (Drug Gene Interaction Database)OAS2
DoCM (Curated mutations)OAS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OAS2 (select a term)
intoGenOAS2
Cancer3DOAS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603350   
Orphanet
MedgenOAS2
Genetic Testing Registry OAS2
NextProtP29728 [Medical]
TSGene4939
GENETestsOAS2
Huge Navigator OAS2 [HugePedia]
snp3D : Map Gene to Disease4939
BioCentury BCIQOAS2
ClinGenOAS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4939
Chemical/Pharm GKB GenePA31876
Clinical trialOAS2
Miscellaneous
canSAR (ICR)OAS2 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOAS2
EVEXOAS2
GoPubMedOAS2
iHOPOAS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:19:42 CET 2017

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