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OAS3 (2'-5'-oligoadenylate synthetase 3)

Identity

Alias_names2'-5'-oligoadenylate synthetase 3 (100 kD)
2'-5'-oligoadenylate synthetase 3, 100kDa
Other aliasp100
p100OAS
HGNC (Hugo) OAS3
LocusID (NCBI) 4940
Atlas_Id 55214
Location 12q24.13  [Link to chromosome band 12q24]
Location_base_pair Starts at 113376238 and ends at 113411055 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACOT1 (14q24.3) / OAS3 (12q24.13)OAS3 (12q24.13) / RPH3A (12q24.13)OAS3 12q24.13 / RPH3A 12q24.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OAS3   8088
Cards
Entrez_Gene (NCBI)OAS3  4940  2'-5'-oligoadenylate synthetase 3
Aliasesp100; p100OAS
GeneCards (Weizmann)OAS3
Ensembl hg19 (Hinxton)ENSG00000111331 [Gene_View]  chr12:113376238-113411055 [Contig_View]  OAS3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000111331 [Gene_View]  chr12:113376238-113411055 [Contig_View]  OAS3 [Vega]
ICGC DataPortalENSG00000111331
TCGA cBioPortalOAS3
AceView (NCBI)OAS3
Genatlas (Paris)OAS3
WikiGenes4940
SOURCE (Princeton)OAS3
Genetics Home Reference (NIH)OAS3
Genomic and cartography
GoldenPath hg19 (UCSC)OAS3  -     chr12:113376238-113411055 +  12q24.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)OAS3  -     12q24.13   [Description]    (hg38-Dec_2013)
EnsemblOAS3 - 12q24.13 [CytoView hg19]  OAS3 - 12q24.13 [CytoView hg38]
Mapping of homologs : NCBIOAS3 [Mapview hg19]  OAS3 [Mapview hg38]
OMIM603351   
Gene and transcription
Genbank (Entrez)AB044545 AF063613 AK000608 AK292949 BC012015
RefSeq transcript (Entrez)NM_006187
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_029419 NW_004929385
Consensus coding sequences : CCDS (NCBI)OAS3
Cluster EST : UnigeneHs.744211 [ NCBI ]
CGAP (NCI)Hs.744211
Alternative Splicing GalleryENSG00000111331
Gene ExpressionOAS3 [ NCBI-GEO ]   OAS3 [ EBI - ARRAY_EXPRESS ]   OAS3 [ SEEK ]   OAS3 [ MEM ]
Gene Expression Viewer (FireBrowse)OAS3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4940
GTEX Portal (Tissue expression)OAS3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6K5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6K5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6K5
Splice isoforms : SwissVarQ9Y6K5
Catalytic activity : Enzyme2.7.7.84 [ Enzyme-Expasy ]   2.7.7.842.7.7.84 [ IntEnz-EBI ]   2.7.7.84 [ BRENDA ]   2.7.7.84 [ KEGG ]   
PhosPhoSitePlusQ9Y6K5
Domaine pattern : Prosite (Expaxy)25A_SYNTH_1 (PS00832)    25A_SYNTH_2 (PS00833)    25A_SYNTH_3 (PS50152)   
Domains : Interpro (EBI)2-5-oligoadenylate_synth_CS    2-5-oligoadenylate_synth_N    2-5-oligoAdlate_synth_1_dom2/C    2-5A_synthase    Polymerase_NTP_transf_dom   
Domain families : Pfam (Sanger)NTP_transf_2 (PF01909)    OAS1_C (PF10421)   
Domain families : Pfam (NCBI)pfam01909    pfam10421   
Conserved Domain (NCBI)OAS3
DMDM Disease mutations4940
Blocks (Seattle)OAS3
PDB (SRS)4S3N   
PDB (PDBSum)4S3N   
PDB (IMB)4S3N   
PDB (RSDB)4S3N   
Structural Biology KnowledgeBase4S3N   
SCOP (Structural Classification of Proteins)4S3N   
CATH (Classification of proteins structures)4S3N   
SuperfamilyQ9Y6K5
Human Protein AtlasENSG00000111331
Peptide AtlasQ9Y6K5
HPRD04519
IPIIPI00002405   IPI01015393   IPI01022387   IPI01022262   IPI01022124   IPI01020702   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6K5
IntAct (EBI)Q9Y6K5
FunCoupENSG00000111331
BioGRIDOAS3
STRING (EMBL)OAS3
ZODIACOAS3
Ontologies - Pathways
QuickGOQ9Y6K5
Ontology : AmiGO2'-5'-oligoadenylate synthetase activity  double-stranded RNA binding  protein binding  ATP binding  extracellular space  nucleoplasm  cytoplasm  cytosol  plasma membrane  nucleobase-containing compound metabolic process  response to virus  intracellular membrane-bounded organelle  negative regulation of viral genome replication  metal ion binding  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  regulation of ribonuclease activity  
Ontology : EGO-EBI2'-5'-oligoadenylate synthetase activity  double-stranded RNA binding  protein binding  ATP binding  extracellular space  nucleoplasm  cytoplasm  cytosol  plasma membrane  nucleobase-containing compound metabolic process  response to virus  intracellular membrane-bounded organelle  negative regulation of viral genome replication  metal ion binding  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  regulation of ribonuclease activity  
Pathways : KEGGHepatitis C    Measles    Influenza A    Herpes simplex infection   
NDEx NetworkOAS3
Atlas of Cancer Signalling NetworkOAS3
Wikipedia pathwaysOAS3
Orthology - Evolution
OrthoDB4940
GeneTree (enSembl)ENSG00000111331
Phylogenetic Trees/Animal Genes : TreeFamOAS3
HOVERGENQ9Y6K5
HOGENOMQ9Y6K5
Homologs : HomoloGeneOAS3
Homology/Alignments : Family Browser (UCSC)OAS3
Gene fusions - Rearrangements
Fusion : MitelmanOAS3/RPH3A [12q24.13/12q24.13]  
Fusion: TCGAOAS3 12q24.13 RPH3A 12q24.13 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOAS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OAS3
dbVarOAS3
ClinVarOAS3
1000_GenomesOAS3 
Exome Variant ServerOAS3
ExAC (Exome Aggregation Consortium)OAS3 (select the gene name)
Genetic variants : HAPMAP4940
Genomic Variants (DGV)OAS3 [DGVbeta]
DECIPHER (Syndromes)12:113376238-113411055  ENSG00000111331
CONAN: Copy Number AnalysisOAS3 
Mutations
ICGC Data PortalOAS3 
TCGA Data PortalOAS3 
Broad Tumor PortalOAS3
OASIS PortalOAS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOAS3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOAS3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OAS3
DgiDB (Drug Gene Interaction Database)OAS3
DoCM (Curated mutations)OAS3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OAS3 (select a term)
intoGenOAS3
Cancer3DOAS3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603351   
Orphanet
MedgenOAS3
Genetic Testing Registry OAS3
NextProtQ9Y6K5 [Medical]
TSGene4940
GENETestsOAS3
Huge Navigator OAS3 [HugePedia]
snp3D : Map Gene to Disease4940
BioCentury BCIQOAS3
ClinGenOAS3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4940
Chemical/Pharm GKB GenePA31877
Clinical trialOAS3
Miscellaneous
canSAR (ICR)OAS3 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOAS3
EVEXOAS3
GoPubMedOAS3
iHOPOAS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:12:58 CEST 2017

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