OAS3 (2-5-oligoadenylate synthetase 3)

2015-05-01  

Identity

HGNC
LOCATION
12q24.13
LOCUSID
ALIAS
p100,p100OAS
FUSION GENES

Other Information

Locus ID:

NCBI: 4940
MIM: 603351
HGNC: 8088
Ensembl: ENSG00000111331

Variants:

dbSNP: 4940
ClinVar: 4940
TCGA: ENSG00000111331
COSMIC: OAS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111331ENST00000228928Q9Y6K5
ENSG00000111331ENST00000546973H0YHL3
ENSG00000111331ENST00000548514F8VS35
ENSG00000111331ENST00000551007F8VWK9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
174088442007The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation.72
268584072016Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.57
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
210501262010Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease.24
210501262010Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease.24
160146972006Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype?23
252751292014The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation.23
231961812013The ribonuclease L-dependent antiviral roles of human 2',5'-oligoadenylate synthetase family members against hepatitis C virus.22
196672182009Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis.21
278991332016Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.20

Citation

Dessen P

OAS3 (2-5-oligoadenylate synthetase 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55214/oas3