Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

OASL (2'-5'-oligoadenylate synthetase like)

Identity

Alias_names2'-5'-oligoadenylate synthetase-like
Alias_symbol (synonym)TRIP14
p59OASL
Other aliasOASLd
TRIP-14
p59 OASL
p59-OASL
HGNC (Hugo) OASL
LocusID (NCBI) 8638
Atlas_Id 53545
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 121020292 and ends at 121039242 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GSS (20q11.22) / OASL (12q24.31)MTUS1 (8p22) / OASL (12q24.31)OASL (12q24.31) / BOLA2 (16p11.2)
OASL (12q24.31) / KIAA1191 (5q35.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OASL   8090
Cards
Entrez_Gene (NCBI)OASL  8638  2'-5'-oligoadenylate synthetase like
AliasesOASLd; TRIP-14; TRIP14; p59; 
p59-OASL; p59OASL
GeneCards (Weizmann)OASL
Ensembl hg19 (Hinxton)ENSG00000135114 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135114 [Gene_View]  chr12:121020292-121039242 [Contig_View]  OASL [Vega]
ICGC DataPortalENSG00000135114
TCGA cBioPortalOASL
AceView (NCBI)OASL
Genatlas (Paris)OASL
WikiGenes8638
SOURCE (Princeton)OASL
Genetics Home Reference (NIH)OASL
Genomic and cartography
GoldenPath hg38 (UCSC)OASL  -     chr12:121020292-121039242 -  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OASL  -     12q24.31   [Description]    (hg19-Feb_2009)
EnsemblOASL - 12q24.31 [CytoView hg19]  OASL - 12q24.31 [CytoView hg38]
Mapping of homologs : NCBIOASL [Mapview hg19]  OASL [Mapview hg38]
OMIM603281   
Gene and transcription
Genbank (Entrez)AJ225089 AK023956 AK314419 AL711263 AW069118
RefSeq transcript (Entrez)NM_001261825 NM_003733 NM_198213
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OASL
Cluster EST : UnigeneHs.118633 [ NCBI ]
CGAP (NCI)Hs.118633
Alternative Splicing GalleryENSG00000135114
Gene ExpressionOASL [ NCBI-GEO ]   OASL [ EBI - ARRAY_EXPRESS ]   OASL [ SEEK ]   OASL [ MEM ]
Gene Expression Viewer (FireBrowse)OASL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8638
GTEX Portal (Tissue expression)OASL
Human Protein AtlasENSG00000135114-OASL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15646   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15646  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15646
Splice isoforms : SwissVarQ15646
PhosPhoSitePlusQ15646
Domaine pattern : Prosite (Expaxy)25A_SYNTH_1 (PS00832)    25A_SYNTH_2 (PS00833)    25A_SYNTH_3 (PS50152)    UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)2-5-oligoadenylate_synth_CS    2-5-oligoadenylate_synth_N    2-5-oligoAdlate_synth_1_dom2/C    2-5A_synthase    Ubiquitin-rel_dom    Ubiquitin_dom   
Domain families : Pfam (Sanger)OAS1_C (PF10421)    ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam10421    pfam00240   
Domain families : Smart (EMBL)UBQ (SM00213)  
Conserved Domain (NCBI)OASL
DMDM Disease mutations8638
Blocks (Seattle)OASL
PDB (SRS)1WH3    4XQ7   
PDB (PDBSum)1WH3    4XQ7   
PDB (IMB)1WH3    4XQ7   
PDB (RSDB)1WH3    4XQ7   
Structural Biology KnowledgeBase1WH3    4XQ7   
SCOP (Structural Classification of Proteins)1WH3    4XQ7   
CATH (Classification of proteins structures)1WH3    4XQ7   
SuperfamilyQ15646
Human Protein Atlas [tissue]ENSG00000135114-OASL [tissue]
Peptide AtlasQ15646
HPRD04473
IPIIPI00018810   IPI00218116   IPI01012715   
Protein Interaction databases
DIP (DOE-UCLA)Q15646
IntAct (EBI)Q15646
FunCoupENSG00000135114
BioGRIDOASL
STRING (EMBL)OASL
ZODIACOASL
Ontologies - Pathways
QuickGOQ15646
Ontology : AmiGO2'-5'-oligoadenylate synthetase activity  DNA binding  RNA binding  double-stranded RNA binding  ATP binding  nucleoplasm  nucleolus  cytoplasm  cytosol  cytosol  response to virus  membrane  negative regulation of viral genome replication  thyroid hormone receptor binding  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  
Ontology : EGO-EBI2'-5'-oligoadenylate synthetase activity  DNA binding  RNA binding  double-stranded RNA binding  ATP binding  nucleoplasm  nucleolus  cytoplasm  cytosol  cytosol  response to virus  membrane  negative regulation of viral genome replication  thyroid hormone receptor binding  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  
NDEx NetworkOASL
Atlas of Cancer Signalling NetworkOASL
Wikipedia pathwaysOASL
Orthology - Evolution
OrthoDB8638
GeneTree (enSembl)ENSG00000135114
Phylogenetic Trees/Animal Genes : TreeFamOASL
HOVERGENQ15646
HOGENOMQ15646
Homologs : HomoloGeneOASL
Homology/Alignments : Family Browser (UCSC)OASL
Gene fusions - Rearrangements
Tumor Fusion PortalOASL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOASL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OASL
dbVarOASL
ClinVarOASL
1000_GenomesOASL 
Exome Variant ServerOASL
ExAC (Exome Aggregation Consortium)ENSG00000135114
GNOMAD BrowserENSG00000135114
Genetic variants : HAPMAP8638
Genomic Variants (DGV)OASL [DGVbeta]
DECIPHEROASL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOASL 
Mutations
ICGC Data PortalOASL 
TCGA Data PortalOASL 
Broad Tumor PortalOASL
OASIS PortalOASL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOASL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOASL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch OASL
DgiDB (Drug Gene Interaction Database)OASL
DoCM (Curated mutations)OASL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OASL (select a term)
intoGenOASL
Cancer3DOASL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603281   
Orphanet
DisGeNETOASL
MedgenOASL
Genetic Testing Registry OASL
NextProtQ15646 [Medical]
TSGene8638
GENETestsOASL
Target ValidationOASL
Huge Navigator OASL [HugePedia]
snp3D : Map Gene to Disease8638
BioCentury BCIQOASL
ClinGenOASL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8638
Chemical/Pharm GKB GenePA31879
Clinical trialOASL
Miscellaneous
canSAR (ICR)OASL (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOASL
EVEXOASL
GoPubMedOASL
iHOPOASL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:27:06 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.