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OASL (2'-5'-oligoadenylate synthetase like)

Identity

Alias (NCBI)OASL1
OASLd
TRIP-14
TRIP14
p59 OASL
p59-OASL
p59OASL
HGNC (Hugo) OASL
HGNC Alias symbTRIP14
p59OASL
OASL1
HGNC Previous name2'-5'-oligoadenylate synthetase-like
LocusID (NCBI) 8638
Atlas_Id 53545
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 121020292 and ends at 121039242 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GSS (20q11.22) / OASL (12q24.31)MTUS1 (8p22) / OASL (12q24.31)OASL (12q24.31) / BOLA2 (16p11.2)
OASL (12q24.31) / KIAA1191 (5q35.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)OASL   8090
Cards
Entrez_Gene (NCBI)OASL    2'-5'-oligoadenylate synthetase like
AliasesOASL1; OASLd; TRIP-14; TRIP14; 
p59; p59-OASL; p59OASL
GeneCards (Weizmann)OASL
Ensembl hg19 (Hinxton)ENSG00000135114 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135114 [Gene_View]  ENSG00000135114 [Sequence]  chr12:121020292-121039242 [Contig_View]  OASL [Vega]
ICGC DataPortalENSG00000135114
TCGA cBioPortalOASL
AceView (NCBI)OASL
Genatlas (Paris)OASL
SOURCE (Princeton)OASL
Genetics Home Reference (NIH)OASL
Genomic and cartography
GoldenPath hg38 (UCSC)OASL  -     chr12:121020292-121039242 -  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OASL  -     12q24.31   [Description]    (hg19-Feb_2009)
GoldenPathOASL - 12q24.31 [CytoView hg19]  OASL - 12q24.31 [CytoView hg38]
ImmunoBaseENSG00000135114
Genome Data Viewer NCBIOASL [Mapview hg19]  
OMIM603281   
Gene and transcription
Genbank (Entrez)AJ225089 AK023956 AK314419 AL711263 AW069118
RefSeq transcript (Entrez)NM_001261825 NM_003733 NM_198213
Consensus coding sequences : CCDS (NCBI)OASL
Gene ExpressionOASL [ NCBI-GEO ]   OASL [ EBI - ARRAY_EXPRESS ]   OASL [ SEEK ]   OASL [ MEM ]
Gene Expression Viewer (FireBrowse)OASL [ Firebrowse - Broad ]
GenevisibleExpression of OASL in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8638
GTEX Portal (Tissue expression)OASL
Human Protein AtlasENSG00000135114-OASL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15646   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15646  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15646
PhosPhoSitePlusQ15646
Domaine pattern : Prosite (Expaxy)25A_SYNTH_1 (PS00832)    25A_SYNTH_2 (PS00833)    25A_SYNTH_3 (PS50152)    UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)2-5-oligoAdlate_synth_1_dom2/C    2-5-oligoAdlate_synth_2_sf    2-5A_synthase    2-5OAS_C_CS    2-5OAS_N_CS    NT_2-5OAS_ClassI-CCAase    NT_sf    Ubiquitin-like_dom    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)OAS1_C (PF10421)    ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam10421    pfam00240   
Domain families : Smart (EMBL)UBQ (SM00213)  
Conserved Domain (NCBI)OASL
PDB (RSDB)1WH3    4XQ7   
PDB Europe1WH3    4XQ7   
PDB (PDBSum)1WH3    4XQ7   
PDB (IMB)1WH3    4XQ7   
Structural Biology KnowledgeBase1WH3    4XQ7   
SCOP (Structural Classification of Proteins)1WH3    4XQ7   
CATH (Classification of proteins structures)1WH3    4XQ7   
SuperfamilyQ15646
AlphaFold pdb e-kbQ15646   
Human Protein Atlas [tissue]ENSG00000135114-OASL [tissue]
HPRD04473
Protein Interaction databases
DIP (DOE-UCLA)Q15646
IntAct (EBI)Q15646
BioGRIDOASL
STRING (EMBL)OASL
ZODIACOASL
Ontologies - Pathways
QuickGOQ15646
Ontology : AmiGO2'-5'-oligoadenylate synthetase activity  DNA binding  RNA binding  double-stranded RNA binding  double-stranded RNA binding  protein binding  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  cytosol  cytosol  cytosol  response to virus  membrane  membrane  negative regulation of viral genome replication  negative regulation of viral genome replication  thyroid hormone receptor binding  defense response to virus  defense response to virus  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  regulation of ribonuclease activity  interleukin-27-mediated signaling pathway  positive regulation of RIG-I signaling pathway  
Ontology : EGO-EBI2'-5'-oligoadenylate synthetase activity  DNA binding  RNA binding  double-stranded RNA binding  double-stranded RNA binding  protein binding  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  cytosol  cytosol  cytosol  response to virus  membrane  membrane  negative regulation of viral genome replication  negative regulation of viral genome replication  thyroid hormone receptor binding  defense response to virus  defense response to virus  defense response to virus  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  regulation of ribonuclease activity  interleukin-27-mediated signaling pathway  positive regulation of RIG-I signaling pathway  
NDEx NetworkOASL
Atlas of Cancer Signalling NetworkOASL
Wikipedia pathwaysOASL
Orthology - Evolution
OrthoDB8638
GeneTree (enSembl)ENSG00000135114
Phylogenetic Trees/Animal Genes : TreeFamOASL
Homologs : HomoloGeneOASL
Homology/Alignments : Family Browser (UCSC)OASL
Gene fusions - Rearrangements
Fusion : QuiverOASL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOASL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OASL
dbVarOASL
ClinVarOASL
MonarchOASL
1000_GenomesOASL 
Exome Variant ServerOASL
GNOMAD BrowserENSG00000135114
Varsome BrowserOASL
ACMGOASL variants
VarityQ15646
Genomic Variants (DGV)OASL [DGVbeta]
DECIPHEROASL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOASL 
Mutations
ICGC Data PortalOASL 
TCGA Data PortalOASL 
Broad Tumor PortalOASL
OASIS PortalOASL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOASL  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DOASL
Mutations and Diseases : HGMDOASL
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaOASL
DgiDB (Drug Gene Interaction Database)OASL
DoCM (Curated mutations)OASL
CIViC (Clinical Interpretations of Variants in Cancer)OASL
Cancer3DOASL
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603281   
Orphanet
DisGeNETOASL
MedgenOASL
Genetic Testing Registry OASL
NextProtQ15646 [Medical]
GENETestsOASL
Target ValidationOASL
Huge Navigator OASL [HugePedia]
ClinGenOASL
Clinical trials, drugs, therapy
MyCancerGenomeOASL
Protein Interactions : CTDOASL
Pharm GKB GenePA31879
PharosQ15646
Clinical trialOASL
Miscellaneous
canSAR (ICR)OASL
HarmonizomeOASL
DataMed IndexOASL
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXOASL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:23:38 CEST 2021

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