OASL (2-5-oligoadenylate synthetase like)

2013-11-01 Affiliation

Identity

HGNC

OASL

LOCATION

12q24.31

LOCUSID

8638

ALIAS

OASL1,OASLd,TRIP-14,TRIP14,p59

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8638
MIM: 603281
HGNC: 8090
Ensembl: ENSG00000135114

Variants:

dbSNP: 8638
ClinVar: 8638
TCGA: ENSG00000135114
COSMIC: OASL

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135114	ENST00000257570	Q15646
ENSG00000135114	ENST00000339275	Q15646
ENSG00000135114	ENST00000543677	H0YGP3
ENSG00000135114	ENST00000620239	Q15646

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon alpha/beta signaling	REACTOME	R-HSA-909733
Interferon gamma signaling	REACTOME	R-HSA-877300

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164784024	peginterferon alfa-2b	Chemical	ClinicalAnnotation	associated	PD	21993426
PA444445	Hepatitis C	Disease	ClinicalAnnotation	associated	PD	21993426
PA451241	ribavirin	Chemical	ClinicalAnnotation	associated	PD	21993426

References

Pubmed ID	Year	Title	Citations
24931123	2014	Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.	80
20889853	2011	Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.	65
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
16235172	2005	Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.	46
19203244	2009	Differential regulation of the OASL and OAS1 genes in response to viral infections.	41
21943158	2011	Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.	34
20074559	2010	2',5'-Oligoadenylate synthetase-like gene highly induced by hepatitis C virus infection in human liver is inhibitory to viral replication in vitro.	28
18931074	2008	The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain.	27
21050126	2010	Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease.	24
18571276	2008	Association of single nucleotide polymorphisms in interferon signaling pathway genes and interferon-stimulated genes with the response to interferon therapy for chronic hepatitis C.	20

Citation

Dessen P

OASL (2-5-oligoadenylate synthetase like)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53545/oasl