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OAT (ornithine aminotransferase)

Identity

Alias (NCBI)GACR
HOGA
OATASE
OKT
HGNC (Hugo) OAT
HGNC Alias symbHOGA
HGNC Alias nameOrnithine aminotransferase
 ornithine aminotransferase precursor
 gyrate atrophy
LocusID (NCBI) 4942
Atlas_Id 71083
Location 10q26.13  [Link to chromosome band 10q26]
Location_base_pair Starts at 124397303 and ends at 124418923 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
OAT (10q26.13) / ITCH (20q11.22)SHTN1 (10q25.3) / OAT (10q26.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)OAT   8091
LRG (Locus Reference Genomic)LRG_685
Cards
Entrez_Gene (NCBI)OAT    ornithine aminotransferase
AliasesGACR; HOGA; OATASE; OKT
GeneCards (Weizmann)OAT
Ensembl hg19 (Hinxton)ENSG00000065154 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000065154 [Gene_View]  ENSG00000065154 [Sequence]  chr10:124397303-124418923 [Contig_View]  OAT [Vega]
ICGC DataPortalENSG00000065154
TCGA cBioPortalOAT
AceView (NCBI)OAT
Genatlas (Paris)OAT
SOURCE (Princeton)OAT
Genetics Home Reference (NIH)OAT
Genomic and cartography
GoldenPath hg38 (UCSC)OAT  -     chr10:124397303-124418923 -  10q26.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OAT  -     10q26.13   [Description]    (hg19-Feb_2009)
GoldenPathOAT - 10q26.13 [CytoView hg19]  OAT - 10q26.13 [CytoView hg38]
ImmunoBaseENSG00000065154
Genome Data Viewer NCBIOAT [Mapview hg19]  
OMIM258870   613349   
Gene and transcription
Genbank (Entrez)AB208817 AK296032 AK312561 AK315947 BC000964
RefSeq transcript (Entrez)NM_000274 NM_001171814 NM_001322965 NM_001322966 NM_001322967 NM_001322968 NM_001322969 NM_001322970 NM_001322971 NM_001322974
Consensus coding sequences : CCDS (NCBI)OAT
Gene ExpressionOAT [ NCBI-GEO ]   OAT [ EBI - ARRAY_EXPRESS ]   OAT [ SEEK ]   OAT [ MEM ]
Gene Expression Viewer (FireBrowse)OAT [ Firebrowse - Broad ]
GenevisibleExpression of OAT in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4942
GTEX Portal (Tissue expression)OAT
Human Protein AtlasENSG00000065154-OAT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04181   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04181  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04181
Catalytic activity : Enzyme2.6.1.13 [ Enzyme-Expasy ]   2.6.1.132.6.1.13 [ IntEnz-EBI ]   2.6.1.13 [ BRENDA ]   2.6.1.13 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP04181
Domaine pattern : Prosite (Expaxy)AA_TRANSFER_CLASS_3 (PS00600)   
Domains : Interpro (EBI)Aminotrans_3    Orn_aminotrans    PyrdxlP-dep_Trfase    PyrdxlP-dep_Trfase_dom1    PyrdxlP-dep_Trfase_major   
Domain families : Pfam (Sanger)Aminotran_3 (PF00202)   
Domain families : Pfam (NCBI)pfam00202   
Conserved Domain (NCBI)OAT
PDB (RSDB)1GBN    1OAT    2BYJ    2BYL    2CAN    2OAT    5VWO    6HX7    6OIA   
PDB Europe1GBN    1OAT    2BYJ    2BYL    2CAN    2OAT    5VWO    6HX7    6OIA   
PDB (PDBSum)1GBN    1OAT    2BYJ    2BYL    2CAN    2OAT    5VWO    6HX7    6OIA   
PDB (IMB)1GBN    1OAT    2BYJ    2BYL    2CAN    2OAT    5VWO    6HX7    6OIA   
Structural Biology KnowledgeBase1GBN    1OAT    2BYJ    2BYL    2CAN    2OAT    5VWO    6HX7    6OIA   
SCOP (Structural Classification of Proteins)1GBN    1OAT    2BYJ    2BYL    2CAN    2OAT    5VWO    6HX7    6OIA   
CATH (Classification of proteins structures)1GBN    1OAT    2BYJ    2BYL    2CAN    2OAT    5VWO    6HX7    6OIA   
SuperfamilyP04181
AlphaFold pdb e-kbP04181   
Human Protein Atlas [tissue]ENSG00000065154-OAT [tissue]
HPRD02021
Protein Interaction databases
DIP (DOE-UCLA)P04181
IntAct (EBI)P04181
BioGRIDOAT
STRING (EMBL)OAT
ZODIACOAT
Ontologies - Pathways
QuickGOP04181
Ontology : AmiGOornithine-oxo-acid transaminase activity  protein binding  nucleoplasm  cytoplasm  mitochondrion  mitochondrial matrix  mitochondrial matrix  visual perception  glutamine family amino acid metabolic process  arginine catabolic process to proline via ornithine  arginine catabolic process to glutamate  pyridoxal phosphate binding  identical protein binding  identical protein binding  ornithine(lysine) transaminase activity  L-proline biosynthetic process  
Ontology : EGO-EBIornithine-oxo-acid transaminase activity  protein binding  nucleoplasm  cytoplasm  mitochondrion  mitochondrial matrix  mitochondrial matrix  visual perception  glutamine family amino acid metabolic process  arginine catabolic process to proline via ornithine  arginine catabolic process to glutamate  pyridoxal phosphate binding  identical protein binding  identical protein binding  ornithine(lysine) transaminase activity  L-proline biosynthetic process  
Pathways : BIOCARTACatabolic Pathways for Arginine , Histidine, Glutamate, Glutamine, and Proline [Genes]   
Pathways : KEGGArginine and proline metabolism    Urea cycle and metabolism of amino groups   
NDEx NetworkOAT
Atlas of Cancer Signalling NetworkOAT
Wikipedia pathwaysOAT
Orthology - Evolution
OrthoDB4942
GeneTree (enSembl)ENSG00000065154
Phylogenetic Trees/Animal Genes : TreeFamOAT
Homologs : HomoloGeneOAT
Homology/Alignments : Family Browser (UCSC)OAT
Gene fusions - Rearrangements
Fusion : QuiverOAT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOAT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OAT
dbVarOAT
ClinVarOAT
MonarchOAT
1000_GenomesOAT 
Exome Variant ServerOAT
GNOMAD BrowserENSG00000065154
Varsome BrowserOAT
ACMGOAT variants
VarityP04181
Genomic Variants (DGV)OAT [DGVbeta]
DECIPHEROAT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOAT 
Mutations
ICGC Data PortalOAT 
TCGA Data PortalOAT 
Broad Tumor PortalOAT
OASIS PortalOAT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOAT  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DOAT
Mutations and Diseases : HGMDOAT
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaOAT
DgiDB (Drug Gene Interaction Database)OAT
DoCM (Curated mutations)OAT
CIViC (Clinical Interpretations of Variants in Cancer)OAT
Cancer3DOAT
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM258870    613349   
Orphanet3349   
DisGeNETOAT
MedgenOAT
Genetic Testing Registry OAT
NextProtP04181 [Medical]
GENETestsOAT
Target ValidationOAT
Huge Navigator OAT [HugePedia]
ClinGenOAT
Clinical trials, drugs, therapy
MyCancerGenomeOAT
Protein Interactions : CTDOAT
Pharm GKB GenePA31880
PharosP04181
Clinical trialOAT
Miscellaneous
canSAR (ICR)OAT
HarmonizomeOAT
DataMed IndexOAT
Probes
Litterature
PubMed95 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXOAT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:13:28 CEST 2021

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