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OAT (ornithine aminotransferase)

Identity

Alias_symbol (synonym)HOGA
Other aliasGACR
OATASE
OKT
HGNC (Hugo) OAT
LocusID (NCBI) 4942
Atlas_Id 71083
Location 10q26.13  [Link to chromosome band 10q26]
Location_base_pair Starts at 124397303 and ends at 124418976 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
OAT (10q26.13) / ITCH (20q11.22)SHTN1 (10q25.3) / OAT (10q26.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OAT   8091
LRG (Locus Reference Genomic)LRG_685
Cards
Entrez_Gene (NCBI)OAT  4942  ornithine aminotransferase
AliasesGACR; HOGA; OATASE; OKT
GeneCards (Weizmann)OAT
Ensembl hg19 (Hinxton)ENSG00000065154 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000065154 [Gene_View]  chr10:124397303-124418976 [Contig_View]  OAT [Vega]
ICGC DataPortalENSG00000065154
TCGA cBioPortalOAT
AceView (NCBI)OAT
Genatlas (Paris)OAT
WikiGenes4942
SOURCE (Princeton)OAT
Genetics Home Reference (NIH)OAT
Genomic and cartography
GoldenPath hg38 (UCSC)OAT  -     chr10:124397303-124418976 -  10q26.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OAT  -     10q26.13   [Description]    (hg19-Feb_2009)
EnsemblOAT - 10q26.13 [CytoView hg19]  OAT - 10q26.13 [CytoView hg38]
Mapping of homologs : NCBIOAT [Mapview hg19]  OAT [Mapview hg38]
OMIM258870   613349   
Gene and transcription
Genbank (Entrez)AB208817 AK296032 AK312561 AK315947 BC000964
RefSeq transcript (Entrez)NM_000274 NM_001171814 NM_001322965 NM_001322966 NM_001322967 NM_001322968 NM_001322969 NM_001322970 NM_001322971 NM_001322974
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OAT
Cluster EST : UnigeneHs.523332 [ NCBI ]
CGAP (NCI)Hs.523332
Alternative Splicing GalleryENSG00000065154
Gene ExpressionOAT [ NCBI-GEO ]   OAT [ EBI - ARRAY_EXPRESS ]   OAT [ SEEK ]   OAT [ MEM ]
Gene Expression Viewer (FireBrowse)OAT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4942
GTEX Portal (Tissue expression)OAT
Human Protein AtlasENSG00000065154-OAT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04181   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04181  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04181
Splice isoforms : SwissVarP04181
Catalytic activity : Enzyme2.6.1.13 [ Enzyme-Expasy ]   2.6.1.132.6.1.13 [ IntEnz-EBI ]   2.6.1.13 [ BRENDA ]   2.6.1.13 [ KEGG ]   
PhosPhoSitePlusP04181
Domaine pattern : Prosite (Expaxy)AA_TRANSFER_CLASS_3 (PS00600)   
Domains : Interpro (EBI)Aminotrans_3    Orn_aminotrans    PyrdxlP-dep_Trfase    PyrdxlP-dep_Trfase_major_sub1    PyrdxlP-dep_Trfase_major_sub2   
Domain families : Pfam (Sanger)Aminotran_3 (PF00202)   
Domain families : Pfam (NCBI)pfam00202   
Conserved Domain (NCBI)OAT
DMDM Disease mutations4942
Blocks (Seattle)OAT
PDB (SRS)1GBN    1OAT    2BYJ    2BYL    2CAN    2OAT   
PDB (PDBSum)1GBN    1OAT    2BYJ    2BYL    2CAN    2OAT   
PDB (IMB)1GBN    1OAT    2BYJ    2BYL    2CAN    2OAT   
PDB (RSDB)1GBN    1OAT    2BYJ    2BYL    2CAN    2OAT   
Structural Biology KnowledgeBase1GBN    1OAT    2BYJ    2BYL    2CAN    2OAT   
SCOP (Structural Classification of Proteins)1GBN    1OAT    2BYJ    2BYL    2CAN    2OAT   
CATH (Classification of proteins structures)1GBN    1OAT    2BYJ    2BYL    2CAN    2OAT   
SuperfamilyP04181
Human Protein Atlas [tissue]ENSG00000065154-OAT [tissue]
Peptide AtlasP04181
HPRD02021
IPIIPI00022334   IPI00955490   
Protein Interaction databases
DIP (DOE-UCLA)P04181
IntAct (EBI)P04181
FunCoupENSG00000065154
BioGRIDOAT
STRING (EMBL)OAT
ZODIACOAT
Ontologies - Pathways
QuickGOP04181
Ontology : AmiGOornithine-oxo-acid transaminase activity  nucleoplasm  mitochondrion  mitochondrial matrix  visual perception  cellular amino acid biosynthetic process  pyridoxal phosphate binding  protein hexamerization  identical protein binding  L-proline biosynthetic process  
Ontology : EGO-EBIornithine-oxo-acid transaminase activity  nucleoplasm  mitochondrion  mitochondrial matrix  visual perception  cellular amino acid biosynthetic process  pyridoxal phosphate binding  protein hexamerization  identical protein binding  L-proline biosynthetic process  
Pathways : BIOCARTACatabolic Pathways for Arginine , Histidine, Glutamate, Glutamine, and Proline [Genes]   
Pathways : KEGGArginine and proline metabolism   
NDEx NetworkOAT
Atlas of Cancer Signalling NetworkOAT
Wikipedia pathwaysOAT
Orthology - Evolution
OrthoDB4942
GeneTree (enSembl)ENSG00000065154
Phylogenetic Trees/Animal Genes : TreeFamOAT
HOVERGENP04181
HOGENOMP04181
Homologs : HomoloGeneOAT
Homology/Alignments : Family Browser (UCSC)OAT
Gene fusions - Rearrangements
Tumor Fusion PortalOAT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOAT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OAT
dbVarOAT
ClinVarOAT
1000_GenomesOAT 
Exome Variant ServerOAT
ExAC (Exome Aggregation Consortium)ENSG00000065154
GNOMAD BrowserENSG00000065154
Genetic variants : HAPMAP4942
Genomic Variants (DGV)OAT [DGVbeta]
DECIPHEROAT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOAT 
Mutations
ICGC Data PortalOAT 
TCGA Data PortalOAT 
Broad Tumor PortalOAT
OASIS PortalOAT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOAT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOAT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch OAT
DgiDB (Drug Gene Interaction Database)OAT
DoCM (Curated mutations)OAT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OAT (select a term)
intoGenOAT
Cancer3DOAT(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM258870    613349   
Orphanet3349   
DisGeNETOAT
MedgenOAT
Genetic Testing Registry OAT
NextProtP04181 [Medical]
TSGene4942
GENETestsOAT
Target ValidationOAT
Huge Navigator OAT [HugePedia]
snp3D : Map Gene to Disease4942
BioCentury BCIQOAT
ClinGenOAT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4942
Chemical/Pharm GKB GenePA31880
Clinical trialOAT
Miscellaneous
canSAR (ICR)OAT (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOAT
EVEXOAT
GoPubMedOAT
iHOPOAT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:22:18 CET 2017

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