Atlas of Genetics and Cytogenetics in Oncology and Haematology


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OAZ1 (ornithine decarboxylase antizyme 1)

Identity

Alias_namesOAZ
Alias_symbol (synonym)AZI
MGC138338
Other aliasAZ1
HGNC (Hugo) OAZ1
LocusID (NCBI) 4946
Atlas_Id 49771
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 2269486 and ends at 2273488 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
OAZ1 (19p13.3) / BTBD2 (19p13.3)OAZ1 (19p13.3) / FKBP8 (19p13.11)OAZ1 (19p13.3) / OAZ1 (19p13.3)
OAZ1 (19p13.3) / PLP1 (Xq22.2)OAZ1 (19p13.3) / RNF126 (19p13.3)OAZ1 (19p13.3) / SF3A2 (19p13.3)
OAZ1 (19p13.3) / TXNL1 (18q21.31)OAZ1 (19p13.3) / ULK2 (17p11.2)PYM1 (12q13.2) / OAZ1 (19p13.3)
RPS6 (9p22.1) / OAZ1 (19p13.3)RPS6 9p22.1 / OAZ1 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(19;19)(p13;p13) OAZ1/RNF126


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  Lung: Translocations in Adenocarcinoma
t(9;19)(p22;p13) RPS6/OAZ1
OAZ1/SF3A2 (19p13)


External links

Nomenclature
HGNC (Hugo)OAZ1   8095
Cards
Entrez_Gene (NCBI)OAZ1  4946  ornithine decarboxylase antizyme 1
AliasesAZ1; AZI; OAZ
GeneCards (Weizmann)OAZ1
Ensembl hg19 (Hinxton)ENSG00000104904 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104904 [Gene_View]  ENSG00000104904 [Sequence]  chr19:2269486-2273488 [Contig_View]  OAZ1 [Vega]
ICGC DataPortalENSG00000104904
TCGA cBioPortalOAZ1
AceView (NCBI)OAZ1
Genatlas (Paris)OAZ1
WikiGenes4946
SOURCE (Princeton)OAZ1
Genetics Home Reference (NIH)OAZ1
Genomic and cartography
GoldenPath hg38 (UCSC)OAZ1  -     chr19:2269486-2273488 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OAZ1  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblOAZ1 - 19p13.3 [CytoView hg19]  OAZ1 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIOAZ1 [Mapview hg19]  OAZ1 [Mapview hg38]
OMIM601579   
Gene and transcription
Genbank (Entrez)AF090094 AK307221 AL542477 BC007247 BC010063
RefSeq transcript (Entrez)NM_001301020 NM_004152
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OAZ1
Cluster EST : UnigeneHs.446427 [ NCBI ]
CGAP (NCI)Hs.446427
Alternative Splicing GalleryENSG00000104904
Gene ExpressionOAZ1 [ NCBI-GEO ]   OAZ1 [ EBI - ARRAY_EXPRESS ]   OAZ1 [ SEEK ]   OAZ1 [ MEM ]
Gene Expression Viewer (FireBrowse)OAZ1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4946
GTEX Portal (Tissue expression)OAZ1
Human Protein AtlasENSG00000104904-OAZ1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54368   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP54368  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP54368
Splice isoforms : SwissVarP54368
PhosPhoSitePlusP54368
Domaine pattern : Prosite (Expaxy)ODC_AZ (PS01337)   
Domains : Interpro (EBI)Acyl_CoA_acyltransferase    ODC-AZ_1    ODC_AZ    ODC_AZ_sf   
Domain families : Pfam (Sanger)ODC_AZ (PF02100)   
Domain families : Pfam (NCBI)pfam02100   
Conserved Domain (NCBI)OAZ1
DMDM Disease mutations4946
Blocks (Seattle)OAZ1
PDB (SRS)4ZGY    4ZGZ    5BWA   
PDB (PDBSum)4ZGY    4ZGZ    5BWA   
PDB (IMB)4ZGY    4ZGZ    5BWA   
PDB (RSDB)4ZGY    4ZGZ    5BWA   
Structural Biology KnowledgeBase4ZGY    4ZGZ    5BWA   
SCOP (Structural Classification of Proteins)4ZGY    4ZGZ    5BWA   
CATH (Classification of proteins structures)4ZGY    4ZGZ    5BWA   
SuperfamilyP54368
Human Protein Atlas [tissue]ENSG00000104904-OAZ1 [tissue]
Peptide AtlasP54368
HPRD03346
IPIIPI00219773   
Protein Interaction databases
DIP (DOE-UCLA)P54368
IntAct (EBI)P54368
FunCoupENSG00000104904
BioGRIDOAZ1
STRING (EMBL)OAZ1
ZODIACOAZ1
Ontologies - Pathways
QuickGOP54368
Ontology : AmiGOprotein binding  nucleus  cytoplasm  cytosol  regulation of cellular amino acid metabolic process  polyamine biosynthetic process  ornithine decarboxylase inhibitor activity  ornithine decarboxylase inhibitor activity  ornithine decarboxylase inhibitor activity  negative regulation of catalytic activity  positive regulation of protein catabolic process  positive regulation of protein catabolic process  positive regulation of protein catabolic process  positive regulation of intracellular protein transport  negative regulation of polyamine transmembrane transport  
Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  cytosol  regulation of cellular amino acid metabolic process  polyamine biosynthetic process  ornithine decarboxylase inhibitor activity  ornithine decarboxylase inhibitor activity  ornithine decarboxylase inhibitor activity  negative regulation of catalytic activity  positive regulation of protein catabolic process  positive regulation of protein catabolic process  positive regulation of protein catabolic process  positive regulation of intracellular protein transport  negative regulation of polyamine transmembrane transport  
NDEx NetworkOAZ1
Atlas of Cancer Signalling NetworkOAZ1
Wikipedia pathwaysOAZ1
Orthology - Evolution
OrthoDB4946
GeneTree (enSembl)ENSG00000104904
Phylogenetic Trees/Animal Genes : TreeFamOAZ1
HOVERGENP54368
HOGENOMP54368
Homologs : HomoloGeneOAZ1
Homology/Alignments : Family Browser (UCSC)OAZ1
Gene fusions - Rearrangements
Fusion : MitelmanOAZ1/RNF126 [19p13.3/19p13.3]  
Fusion : MitelmanOAZ1/SF3A2 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion : MitelmanRPS6/OAZ1 [9p22.1/19p13.3]  [t(9;19)(p22;p13)]  
Fusion PortalRPS6 9p22.1 OAZ1 19p13.3 PRAD
Fusion : QuiverOAZ1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOAZ1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OAZ1
dbVarOAZ1
ClinVarOAZ1
1000_GenomesOAZ1 
Exome Variant ServerOAZ1
ExAC (Exome Aggregation Consortium)ENSG00000104904
GNOMAD BrowserENSG00000104904
Varsome BrowserOAZ1
Genetic variants : HAPMAP4946
Genomic Variants (DGV)OAZ1 [DGVbeta]
DECIPHEROAZ1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOAZ1 
Mutations
ICGC Data PortalOAZ1 
TCGA Data PortalOAZ1 
Broad Tumor PortalOAZ1
OASIS PortalOAZ1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOAZ1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOAZ1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OAZ1
DgiDB (Drug Gene Interaction Database)OAZ1
DoCM (Curated mutations)OAZ1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OAZ1 (select a term)
intoGenOAZ1
Cancer3DOAZ1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601579   
Orphanet
DisGeNETOAZ1
MedgenOAZ1
Genetic Testing Registry OAZ1
NextProtP54368 [Medical]
TSGene4946
GENETestsOAZ1
Target ValidationOAZ1
Huge Navigator OAZ1 [HugePedia]
snp3D : Map Gene to Disease4946
BioCentury BCIQOAZ1
ClinGenOAZ1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4946
Chemical/Pharm GKB GenePA31884
Clinical trialOAZ1
Miscellaneous
canSAR (ICR)OAZ1 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOAZ1
EVEXOAZ1
GoPubMedOAZ1
iHOPOAZ1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:27:29 CET 2018

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