OAZ1 (ornithine decarboxylase antizyme 1)

2007-10-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
AZ1,AZI,OAZ
FUSION GENES

Other Information

Locus ID:

NCBI: 4946
MIM: 601579
HGNC: 8095
Ensembl: ENSG00000104904

Variants:

dbSNP: 4946
ClinVar: 4946
TCGA: ENSG00000104904
COSMIC: OAZ1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104904ENST00000582888J3QQY4
ENSG00000104904ENST00000588673K7ERW1
ENSG00000104904ENST00000590943K7EPM6
ENSG00000104904ENST00000602676P54368

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Regulation of ornithine decarboxylase (ODC)REACTOMER-HSA-350562

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
78130171995Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme.158
201857582010The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway.26
163733392006OAZ regulates bone morphogenetic protein signaling through Smad6 activation.17
208613092010Antizyme restrains centrosome amplification by regulating the accumulation of Mps1 at centrosomes.17
220082212012Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide.17
196357962009Critical factors determining dimerization of human antizyme inhibitor.16
263059482015Structural basis of antizyme-mediated regulation of polyamine homeostasis.16
153553082005Regulation of all members of the antizyme family by antizyme inhibitor.13
156707712005Stable siRNA-mediated silencing of antizyme inhibitor: regulation of ornithine decarboxylase activity.12
221570182012Amino acids regulate expression of antizyme-1 to modulate ornithine decarboxylase activity.12

Citation

Dessen P

OAZ1 (ornithine decarboxylase antizyme 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-10-01

Online version: http://atlasgeneticsoncology.org/gene/49771/oaz1