OAZ2 (ornithine decarboxylase antizyme 2)

2016-10-01  

Identity

HGNC
LOCATION
15q22.31
LOCUSID
ALIAS
AZ2
FUSION GENES

Other Information

Locus ID:

NCBI: 4947
MIM: 604152
HGNC: 8096
Ensembl: ENSG00000180304

Variants:

dbSNP: 4947
ClinVar: 4947
TCGA: ENSG00000180304
COSMIC: OAZ2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180304ENST00000326005O95190
ENSG00000180304ENST00000559753J3QLV9
ENSG00000180304ENST00000559912J3KRW5
ENSG00000180304ENST00000560258J3KS80

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Regulation of ornithine decarboxylase (ODC)REACTOMER-HSA-350562

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
97820761998A second mammalian antizyme: conservation of programmed ribosomal frameshifting.41
199604352010The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification.22
220082212012Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide.17
232601692013Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide.12
301751542018miR-34a Regulates Multidrug Resistance via Positively Modulating OAZ2 Signaling in Colon Cancer Cells.5

Citation

Dessen P

OAZ2 (ornithine decarboxylase antizyme 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56100/oaz2