Atlas of Genetics and Cytogenetics in Oncology and Haematology


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OC90 (otoconin 90)

Identity

Alias (NCBI)PLA2L
HGNC (Hugo) OC90
HGNC Previous namePLA2L
LocusID (NCBI) 729330
Atlas_Id 47384
Location 8q24.22  [Link to chromosome band 8q24]
Location_base_pair Starts at 132024216 and ends at 132059382 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AC010859.1 ()::OC90 (8q24.22)EXT1 (8q24.11)::OC90 (8q24.22)TATDN1 (8q24.13)::OC90 (8q24.22)
TMEM64 (8q21.3)::OC90 (8q24.22)AC010859.1 OC90 8q24.22EXT1 8q24.11::OC90 8q24.22
TATDN1 8q24.13::OC90 8q24.22TMEM64 8q21.3::OC90 8q24.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)OC90   8100
Cards
Entrez_Gene (NCBI)OC90    otoconin 90
AliasesPLA2L
GeneCards (Weizmann)OC90
Ensembl hg19 (Hinxton)ENSG00000253117 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000253117 [Gene_View]  ENSG00000253117 [Sequence]  chr8:132024216-132059382 [Contig_View]  OC90 [Vega]
ICGC DataPortalENSG00000253117
TCGA cBioPortalOC90
AceView (NCBI)OC90
Genatlas (Paris)OC90
SOURCE (Princeton)OC90
Genetics Home Reference (NIH)OC90
Genomic and cartography
GoldenPath hg38 (UCSC)OC90  -     chr8:132024216-132059382 -  8q24.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OC90  -     8q24.22   [Description]    (hg19-Feb_2009)
GoldenPathOC90 - 8q24.22 [CytoView hg19]  OC90 - 8q24.22 [CytoView hg38]
ImmunoBaseENSG00000253117
Genome Data Viewer NCBIOC90 [Mapview hg19]  
OMIM601658   
Gene and transcription
Genbank (Entrez)AK297911
RefSeq transcript (Entrez)NM_001080399
Consensus coding sequences : CCDS (NCBI)OC90
Gene ExpressionOC90 [ NCBI-GEO ]   OC90 [ EBI - ARRAY_EXPRESS ]   OC90 [ SEEK ]   OC90 [ MEM ]
Gene Expression Viewer (FireBrowse)OC90 [ Firebrowse - Broad ]
GenevisibleExpression of OC90 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)729330
GTEX Portal (Tissue expression)OC90
Human Protein AtlasENSG00000253117-OC90 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02509   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02509  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02509
PhosPhoSitePlusQ02509
Domaine pattern : Prosite (Expaxy)PA2_ASP (PS00119)    PA2_HIS (PS00118)   
Domains : Interpro (EBI)Otoconin-90    PLipase_A2    PLipase_A2_Asp_AS    PLipase_A2_dom    PLipase_A2_dom_sf    PLipase_A2_His_AS   
Domain families : Pfam (Sanger)Phospholip_A2_1 (PF00068)   
Domain families : Pfam (NCBI)pfam00068   
Domain families : Smart (EMBL)PA2c (SM00085)  
Conserved Domain (NCBI)OC90
SuperfamilyQ02509
AlphaFold pdb e-kbQ02509   
Human Protein Atlas [tissue]ENSG00000253117-OC90 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q02509
IntAct (EBI)Q02509
BioGRIDOC90
STRING (EMBL)OC90
ZODIACOC90
Ontologies - Pathways
QuickGOQ02509
Ontology : AmiGOmolecular_function  phospholipase A2 activity  calcium ion binding  cellular_component  extracellular region  phospholipid metabolic process  biological_process  lipid catabolic process  extracellular matrix  otolith mineralization  arachidonic acid secretion  
Ontology : EGO-EBImolecular_function  phospholipase A2 activity  calcium ion binding  cellular_component  extracellular region  phospholipid metabolic process  biological_process  lipid catabolic process  extracellular matrix  otolith mineralization  arachidonic acid secretion  
NDEx NetworkOC90
Atlas of Cancer Signalling NetworkOC90
Wikipedia pathwaysOC90
Orthology - Evolution
OrthoDB729330
GeneTree (enSembl)ENSG00000253117
Phylogenetic Trees/Animal Genes : TreeFamOC90
Homologs : HomoloGeneOC90
Homology/Alignments : Family Browser (UCSC)OC90
Gene fusions - Rearrangements
Fusion : MitelmanEXT1::OC90 [8q24.11/8q24.22]  
Fusion : MitelmanTATDN1::OC90 [8q24.13/8q24.22]  
Fusion : MitelmanTMEM64::OC90 [8q21.3/8q24.22]  
Fusion : QuiverOC90
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOC90 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OC90
dbVarOC90
ClinVarOC90
MonarchOC90
1000_GenomesOC90 
Exome Variant ServerOC90
GNOMAD BrowserENSG00000253117
Varsome BrowserOC90
ACMGOC90 variants
VarityQ02509
Genomic Variants (DGV)OC90 [DGVbeta]
DECIPHEROC90 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOC90 
Mutations
ICGC Data PortalOC90 
TCGA Data PortalOC90 
Broad Tumor PortalOC90
OASIS PortalOC90 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOC90  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DOC90
Mutations and Diseases : HGMDOC90
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaOC90
DgiDB (Drug Gene Interaction Database)OC90
DoCM (Curated mutations)OC90
CIViC (Clinical Interpretations of Variants in Cancer)OC90
Cancer3DOC90
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601658   
Orphanet
DisGeNETOC90
MedgenOC90
Genetic Testing Registry OC90
NextProtQ02509 [Medical]
GENETestsOC90
Target ValidationOC90
Huge Navigator OC90 [HugePedia]
ClinGenOC90
Clinical trials, drugs, therapy
MyCancerGenomeOC90
Protein Interactions : CTDOC90
Pharm GKB GenePA31889
PharosQ02509
Clinical trialOC90
Miscellaneous
canSAR (ICR)OC90
HarmonizomeOC90
ARCHS4OC90
DataMed IndexOC90
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXOC90
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:25:42 CET 2022

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