Atlas of Genetics and Cytogenetics in Oncology and Haematology


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OC90 (otoconin 90)

Identity

Alias_namesPLA2L
Other alias
HGNC (Hugo) OC90
LocusID (NCBI) 729330
Atlas_Id 47384
Location 8q24.22  [Link to chromosome band 8q24]
Location_base_pair Starts at 132024220 and ends at 132059380 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AC010859.1 () / OC90 (8q24.22)EXT1 (8q24.11) / OC90 (8q24.22)TATDN1 (8q24.13) / OC90 (8q24.22)
TMEM64 (8q21.3) / OC90 (8q24.22)AC010859.1 OC90 8q24.22EXT1 8q24.11 / OC90 8q24.22
TATDN1 8q24.13 / OC90 8q24.22TMEM64 8q21.3 / OC90 8q24.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OC90   8100
Cards
Entrez_Gene (NCBI)OC90  729330  otoconin 90
AliasesPLA2L
GeneCards (Weizmann)OC90
Ensembl hg19 (Hinxton)ENSG00000253117 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000253117 [Gene_View]  chr8:132024220-132059380 [Contig_View]  OC90 [Vega]
ICGC DataPortalENSG00000253117
TCGA cBioPortalOC90
AceView (NCBI)OC90
Genatlas (Paris)OC90
WikiGenes729330
SOURCE (Princeton)OC90
Genetics Home Reference (NIH)OC90
Genomic and cartography
GoldenPath hg38 (UCSC)OC90  -     chr8:132024220-132059380 -  8q24.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OC90  -     8q24.22   [Description]    (hg19-Feb_2009)
EnsemblOC90 - 8q24.22 [CytoView hg19]  OC90 - 8q24.22 [CytoView hg38]
Mapping of homologs : NCBIOC90 [Mapview hg19]  OC90 [Mapview hg38]
OMIM601658   
Gene and transcription
Genbank (Entrez)AK297911 BC160180
RefSeq transcript (Entrez)NM_001080399
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OC90
Cluster EST : UnigeneHs.653174 [ NCBI ]
CGAP (NCI)Hs.653174
Alternative Splicing GalleryENSG00000253117
Gene ExpressionOC90 [ NCBI-GEO ]   OC90 [ EBI - ARRAY_EXPRESS ]   OC90 [ SEEK ]   OC90 [ MEM ]
Gene Expression Viewer (FireBrowse)OC90 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)729330
GTEX Portal (Tissue expression)OC90
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02509   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02509  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02509
Splice isoforms : SwissVarQ02509
PhosPhoSitePlusQ02509
Domaine pattern : Prosite (Expaxy)PA2_ASP (PS00119)    PA2_HIS (PS00118)   
Domains : Interpro (EBI)PLipase_A2    PLipase_A2_Asp_AS    PLipase_A2_dom    PLipase_A2_His_AS   
Domain families : Pfam (Sanger)Phospholip_A2_1 (PF00068)   
Domain families : Pfam (NCBI)pfam00068   
Domain families : Smart (EMBL)PA2c (SM00085)  
Conserved Domain (NCBI)OC90
DMDM Disease mutations729330
Blocks (Seattle)OC90
SuperfamilyQ02509
Human Protein AtlasENSG00000253117
Peptide AtlasQ02509
IPIIPI01024950   IPI00938069   
Protein Interaction databases
DIP (DOE-UCLA)Q02509
IntAct (EBI)Q02509
FunCoupENSG00000253117
BioGRIDOC90
STRING (EMBL)OC90
ZODIACOC90
Ontologies - Pathways
QuickGOQ02509
Ontology : AmiGOmolecular_function  phospholipase A2 activity  calcium ion binding  cellular_component  extracellular region  phospholipid metabolic process  biological_process  lipid catabolic process  arachidonic acid secretion  
Ontology : EGO-EBImolecular_function  phospholipase A2 activity  calcium ion binding  cellular_component  extracellular region  phospholipid metabolic process  biological_process  lipid catabolic process  arachidonic acid secretion  
NDEx NetworkOC90
Atlas of Cancer Signalling NetworkOC90
Wikipedia pathwaysOC90
Orthology - Evolution
OrthoDB729330
GeneTree (enSembl)ENSG00000253117
Phylogenetic Trees/Animal Genes : TreeFamOC90
HOVERGENQ02509
HOGENOMQ02509
Homologs : HomoloGeneOC90
Homology/Alignments : Family Browser (UCSC)OC90
Gene fusions - Rearrangements
Fusion : MitelmanEXT1/OC90 [8q24.11/8q24.22]  [t(8;8)(q24;q24)]  
Fusion : MitelmanTATDN1/OC90 [8q24.13/8q24.22]  [t(8;8)(q24;q24)]  
Fusion : MitelmanTMEM64/OC90 [8q21.3/8q24.22]  [t(8;8)(q21;q24)]  
Fusion: TCGAAC010859.1 OC90 8q24.22 BRCA
Fusion: TCGAEXT1 8q24.11 OC90 8q24.22 LUAD
Fusion: TCGATATDN1 8q24.13 OC90 8q24.22 BRCA
Fusion: TCGATMEM64 8q21.3 OC90 8q24.22 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOC90 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OC90
dbVarOC90
ClinVarOC90
1000_GenomesOC90 
Exome Variant ServerOC90
ExAC (Exome Aggregation Consortium)OC90 (select the gene name)
Genetic variants : HAPMAP729330
Genomic Variants (DGV)OC90 [DGVbeta]
DECIPHEROC90 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOC90 
Mutations
ICGC Data PortalOC90 
TCGA Data PortalOC90 
Broad Tumor PortalOC90
OASIS PortalOC90 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOC90  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOC90
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OC90
DgiDB (Drug Gene Interaction Database)OC90
DoCM (Curated mutations)OC90 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OC90 (select a term)
intoGenOC90
Cancer3DOC90(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601658   
Orphanet
MedgenOC90
Genetic Testing Registry OC90
NextProtQ02509 [Medical]
TSGene729330
GENETestsOC90
Target ValidationOC90
Huge Navigator OC90 [HugePedia]
snp3D : Map Gene to Disease729330
BioCentury BCIQOC90
ClinGenOC90
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD729330
Chemical/Pharm GKB GenePA31889
Clinical trialOC90
Miscellaneous
canSAR (ICR)OC90 (select the gene name)
Probes
Litterature
PubMed6 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOC90
EVEXOC90
GoPubMedOC90
iHOPOC90
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 14:02:13 CEST 2017

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