OCLN (occludin)

2007-02-01  

Identity

HGNC
LOCATION
5q13.2
LOCUSID
ALIAS
BLCPMG,PPP1R115,PTORCH1
FUSION GENES

Other Information

Locus ID:

NCBI: 100506658
MIM: 602876
HGNC: 8104
Ensembl: ENSG00000197822

Variants:

dbSNP: 100506658
ClinVar: 100506658
TCGA: ENSG00000197822
COSMIC: OCLN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197822ENST00000355237Q16625
ENSG00000197822ENST00000396442Q16625
ENSG00000197822ENST00000538151Q16625

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Pathogenic Escherichia coli infectionKEGGko05130
Cell adhesion molecules (CAMs)KEGGhsa04514
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Pathogenic Escherichia coli infectionKEGGhsa05130
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Apoptotic cleavage of cell adhesion proteinsREACTOMER-HSA-351906

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
126687232003Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail.216
191745162009VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown.165
190520942009Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection.145
184746222008The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state.137
121690982002Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress.118
180057332007Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5.107
201642572010Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions.104
215367522011Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function.89
161349682006MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide.81
190176512009Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions.70

Citation

Dessen P

OCLN (occludin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46084/ocln