ODF2 (outer dense fiber of sperm tails 2)

2014-08-01  

Identity

HGNC
ODF2
LOCATION
9q34.11
LOCUSID
4957
ALIAS
CT134,ODF2/1,ODF2/2,ODF84
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4957
MIM: 602015
HGNC: 8114
Ensembl: ENSG00000136811

Variants:

dbSNP: 4957
ClinVar: 4957
TCGA: ENSG00000136811
COSMIC: ODF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136811ENST00000351030Q5BJF6
ENSG00000136811ENST00000372791Q5BJF6
ENSG00000136811ENST00000372791A0A024R8A4
ENSG00000136811ENST00000372807Q5BJF6
ENSG00000136811ENST00000372814Q5BJF6
ENSG00000136811ENST00000393527Q5BJF6
ENSG00000136811ENST00000393527A0A024R8A5
ENSG00000136811ENST00000393533Q5BJF6
ENSG00000136811ENST00000421776Q5T4C3
ENSG00000136811ENST00000432065Q5T4C6
ENSG00000136811ENST00000434106Q5BJF6
ENSG00000136811ENST00000444119Q5BJF6
ENSG00000136811ENST00000444119A0A024R8A5
ENSG00000136811ENST00000446274Q5T4C8
ENSG00000136811ENST00000448249Q5BJF6
ENSG00000136811ENST00000470061S4R462
ENSG00000136811ENST00000483070S4R3R9
ENSG00000136811ENST00000497812S4R411
ENSG00000136811ENST00000546203Q5BJF6
ENSG00000136811ENST00000604420Q5BJF6

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
193862632009Plk1-dependent and -independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cells.43
213250312011Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein.35
169663752006Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes.31
229117432012A Wnt/beta-catenin pathway antagonist Chibby binds Cenexin at the distal end of mother centrioles and functions in primary cilia formation.22
97403241998Mouse Odf2 cDNAs consist of evolutionary conserved as well as highly variable sequences and encode outer dense fiber proteins of the sperm tail.19
269488792016The Mother Centriole Appendage Protein Cenexin Modulates Lumen Formation through Spindle Orientation.11
202341882010Cdk5 in the centriolar appendages mediates cenexin1 localization and primary cilia formation.6
306235242019Cep128 associates with Odf2 to form the subdistal appendage of the centriole.4

Citation

Dessen P

ODF2 (outer dense fiber of sperm tails 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54516/odf2