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OGDH (oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide))

Identity

Alias_namesoxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Alias_symbol (synonym)E1k
Other aliasAKGDH
OGDC
HGNC (Hugo) OGDH
LocusID (NCBI) 4967
Atlas_Id 71101
Location 7p13  [Link to chromosome band 7p13]
Location_base_pair Starts at 44646121 and ends at 44716195 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DCTN1 (2p13.1) / OGDH (7p13)MTATP6P1 () / OGDH (7p13)OGDH (7p13) / AMPH (7p14.1)
OGDH (7p13) / OGDH (7p13)OGDH (7p13) / PAN3-AS1 (13q12.2)PPIA (7p13) / OGDH (7p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OGDH   8124
Cards
Entrez_Gene (NCBI)OGDH  4967  oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
AliasesAKGDH; E1k; OGDC
GeneCards (Weizmann)OGDH
Ensembl hg19 (Hinxton)ENSG00000105953 [Gene_View]  chr7:44646121-44716195 [Contig_View]  OGDH [Vega]
Ensembl hg38 (Hinxton)ENSG00000105953 [Gene_View]  chr7:44646121-44716195 [Contig_View]  OGDH [Vega]
ICGC DataPortalENSG00000105953
TCGA cBioPortalOGDH
AceView (NCBI)OGDH
Genatlas (Paris)OGDH
WikiGenes4967
SOURCE (Princeton)OGDH
Genetics Home Reference (NIH)OGDH
Genomic and cartography
GoldenPath hg19 (UCSC)OGDH  -     chr7:44646121-44716195 +  7p13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)OGDH  -     7p13   [Description]    (hg38-Dec_2013)
EnsemblOGDH - 7p13 [CytoView hg19]  OGDH - 7p13 [CytoView hg38]
Mapping of homologs : NCBIOGDH [Mapview hg19]  OGDH [Mapview hg38]
OMIM203740   613022   
Gene and transcription
Genbank (Entrez)AI244565 AK293871 AK294951 AK296400 AK302805
RefSeq transcript (Entrez)NM_001003941 NM_001165036 NM_002541
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_023260 NT_007819 NW_004929329
Consensus coding sequences : CCDS (NCBI)OGDH
Cluster EST : UnigeneHs.488181 [ NCBI ]
CGAP (NCI)Hs.488181
Alternative Splicing GalleryENSG00000105953
Gene ExpressionOGDH [ NCBI-GEO ]   OGDH [ EBI - ARRAY_EXPRESS ]   OGDH [ SEEK ]   OGDH [ MEM ]
Gene Expression Viewer (FireBrowse)OGDH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4967
GTEX Portal (Tissue expression)OGDH
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02218   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02218  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02218
Splice isoforms : SwissVarQ02218
Catalytic activity : Enzyme1.2.4.2 [ Enzyme-Expasy ]   1.2.4.21.2.4.2 [ IntEnz-EBI ]   1.2.4.2 [ BRENDA ]   1.2.4.2 [ KEGG ]   
PhosPhoSitePlusQ02218
Domains : Interpro (EBI)2oxoglutarate_DH_E1    DH_E1    THDP-binding    Transketolase-like_Pyr-bd   
Domain families : Pfam (Sanger)E1_dh (PF00676)    Transket_pyr (PF02779)   
Domain families : Pfam (NCBI)pfam00676    pfam02779   
Domain families : Smart (EMBL)Transket_pyr (SM00861)  
Conserved Domain (NCBI)OGDH
DMDM Disease mutations4967
Blocks (Seattle)OGDH
PDB (SRS)3ERY   
PDB (PDBSum)3ERY   
PDB (IMB)3ERY   
PDB (RSDB)3ERY   
Structural Biology KnowledgeBase3ERY   
SCOP (Structural Classification of Proteins)3ERY   
CATH (Classification of proteins structures)3ERY   
SuperfamilyQ02218
Human Protein AtlasENSG00000105953
Peptide AtlasQ02218
HPRD08938
IPIIPI00098902   IPI00956581   IPI00926312   IPI00829595   IPI00910683   IPI00926925   IPI00386497   IPI00927344   
Protein Interaction databases
DIP (DOE-UCLA)Q02218
IntAct (EBI)Q02218
FunCoupENSG00000105953
BioGRIDOGDH
STRING (EMBL)OGDH
ZODIACOGDH
Ontologies - Pathways
QuickGOQ02218
Ontology : AmiGOoxoglutarate dehydrogenase (succinyl-transferring) activity  oxoglutarate dehydrogenase (succinyl-transferring) activity  mitochondrion  mitochondrial matrix  cytosol  generation of precursor metabolites and energy  glycolytic process  tricarboxylic acid cycle  tricarboxylic acid cycle  2-oxoglutarate metabolic process  succinyl-CoA metabolic process  lysine catabolic process  NADH metabolic process  cerebellar cortex development  striatum development  hippocampus development  thalamus development  pyramidal neuron development  tangential migration from the subventricular zone to the olfactory bulb  thiamine pyrophosphate binding  heat shock protein binding  mitochondrial membrane  oxoglutarate dehydrogenase (NAD+) activity  cellular nitrogen compound metabolic process  cellular metabolic process  small molecule metabolic process  oxoglutarate dehydrogenase complex  metal ion binding  chaperone binding  olfactory bulb mitral cell layer development  
Ontology : EGO-EBIoxoglutarate dehydrogenase (succinyl-transferring) activity  oxoglutarate dehydrogenase (succinyl-transferring) activity  mitochondrion  mitochondrial matrix  cytosol  generation of precursor metabolites and energy  glycolytic process  tricarboxylic acid cycle  tricarboxylic acid cycle  2-oxoglutarate metabolic process  succinyl-CoA metabolic process  lysine catabolic process  NADH metabolic process  cerebellar cortex development  striatum development  hippocampus development  thalamus development  pyramidal neuron development  tangential migration from the subventricular zone to the olfactory bulb  thiamine pyrophosphate binding  heat shock protein binding  mitochondrial membrane  oxoglutarate dehydrogenase (NAD+) activity  cellular nitrogen compound metabolic process  cellular metabolic process  small molecule metabolic process  oxoglutarate dehydrogenase complex  metal ion binding  chaperone binding  olfactory bulb mitral cell layer development  
Pathways : KEGGCitrate cycle (TCA cycle)    Lysine degradation    Tryptophan metabolism   
NDEx NetworkOGDH
Atlas of Cancer Signalling NetworkOGDH
Wikipedia pathwaysOGDH
Orthology - Evolution
OrthoDB4967
GeneTree (enSembl)ENSG00000105953
Phylogenetic Trees/Animal Genes : TreeFamOGDH
HOVERGENQ02218
HOGENOMQ02218
Homologs : HomoloGeneOGDH
Homology/Alignments : Family Browser (UCSC)OGDH
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOGDH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OGDH
dbVarOGDH
ClinVarOGDH
1000_GenomesOGDH 
Exome Variant ServerOGDH
ExAC (Exome Aggregation Consortium)OGDH (select the gene name)
Genetic variants : HAPMAP4967
Genomic Variants (DGV)OGDH [DGVbeta]
DECIPHER (Syndromes)7:44646121-44716195  ENSG00000105953
CONAN: Copy Number AnalysisOGDH 
Mutations
ICGC Data PortalOGDH 
TCGA Data PortalOGDH 
Broad Tumor PortalOGDH
OASIS PortalOGDH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOGDH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOGDH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch OGDH
DgiDB (Drug Gene Interaction Database)OGDH
DoCM (Curated mutations)OGDH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OGDH (select a term)
intoGenOGDH
Cancer3DOGDH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM203740    613022   
Orphanet1259   
MedgenOGDH
Genetic Testing Registry OGDH
NextProtQ02218 [Medical]
TSGene4967
GENETestsOGDH
Huge Navigator OGDH [HugePedia]
snp3D : Map Gene to Disease4967
BioCentury BCIQOGDH
ClinGenOGDH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4967
Chemical/Pharm GKB GenePA31910
Clinical trialOGDH
Miscellaneous
canSAR (ICR)OGDH (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOGDH
EVEXOGDH
GoPubMedOGDH
iHOPOGDH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:35:48 CET 2017

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