OGDH (oxoglutarate dehydrogenase)

2018-07-01  

Identity

HGNC
LOCATION
7p13
LOCUSID
ALIAS
AKGDH,E1k,KGD1,OGDC,OGDH2
FUSION GENES

Other Information

Locus ID:

NCBI: 4967
MIM: 613022
HGNC: 8124
Ensembl: ENSG00000105953

Variants:

dbSNP: 4967
ClinVar: 4967
TCGA: ENSG00000105953
COSMIC: OGDH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105953ENST00000222673Q02218
ENSG00000105953ENST00000419661C9J4G7
ENSG00000105953ENST00000439616E9PFG7
ENSG00000105953ENST00000443864Q02218
ENSG00000105953ENST00000443864A0A140VJQ5
ENSG00000105953ENST00000444676E9PCR7
ENSG00000105953ENST00000447398E9PDF2
ENSG00000105953ENST00000449767Q02218
ENSG00000105953ENST00000631326A0A0D9SFS3

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Citrate cycle (TCA cycle)KEGGko00020
Lysine degradationKEGGko00310
Tryptophan metabolismKEGGko00380
Citrate cycle (TCA cycle)KEGGhsa00020
Lysine degradationKEGGhsa00310
Tryptophan metabolismKEGGhsa00380
Metabolic pathwaysKEGGhsa01100
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetateKEGGhsa_M00011
Lysine degradation, lysine => saccharopine => acetoacetyl-CoAKEGGhsa_M00032
Citrate cycle (TCA cycle, Krebs cycle)KEGGM00009
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetateKEGGM00011
Lysine degradation, lysine => saccharopine => acetoacetyl-CoAKEGGM00032
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Citrate cycle (TCA cycle, Krebs cycle)KEGGhsa_M00009
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Citric acid cycle (TCA cycle)REACTOMER-HSA-71403
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Lysine catabolismREACTOMER-HSA-71064
Glyoxylate metabolism and glycine degradationREACTOMER-HSA-389661
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA451846valproic acidChemicalPathwayassociated23407051

References

Pubmed IDYearTitleCitations
279237732016Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.27
154668522004Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah.19
156498992005Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity.19
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
234758502013The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation.13
221691992012Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation.12
274688712016Frameshift mutations of OGDH, PPAT and PCCA genes in gastric and colorectal cancers.7
269369702016Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression.6
283963872017<i>PIK3CA</i> mutant tumors depend on oxoglutarate dehydrogenase.5
216117302011Exercise training induces similar elevations in the activity of oxoglutarate dehydrogenase and peak oxygen uptake in the human quadriceps muscle.4

Citation

Dessen P

OGDH (oxoglutarate dehydrogenase)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57555/ogdh