OGDHL (oxoglutarate dehydrogenase L)

2013-05-01  

Identity

HGNC
OGDHL
LOCATION
10q11.23
LOCUSID
55753
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55753
MIM: 617513
HGNC: 25590
Ensembl: ENSG00000197444

Variants:

dbSNP: 55753
ClinVar: 55753
TCGA: ENSG00000197444
COSMIC: OGDHL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197444ENST00000374103Q9ULD0
ENSG00000197444ENST00000419399Q9ULD0
ENSG00000197444ENST00000432695Q9ULD0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Citrate cycle (TCA cycle)KEGGko00020
Lysine degradationKEGGko00310
Tryptophan metabolismKEGGko00380
Citrate cycle (TCA cycle)KEGGhsa00020
Lysine degradationKEGGhsa00310
Tryptophan metabolismKEGGhsa00380
Metabolic pathwaysKEGGhsa01100
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetateKEGGhsa_M00011
Lysine degradation, lysine => saccharopine => acetoacetyl-CoAKEGGhsa_M00032
Citrate cycle (TCA cycle, Krebs cycle)KEGGM00009
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetateKEGGM00011
Lysine degradation, lysine => saccharopine => acetoacetyl-CoAKEGGM00032
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Citrate cycle (TCA cycle, Krebs cycle)KEGGhsa_M00009

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
231528002012OGDHL is a modifier of AKT-dependent signaling and NF-κB function.23
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
197248952009Association of gene polymorphisms with chronic kidney disease in Japanese individuals.7
317813112019OGDHL Expression as a Prognostic Biomarker for Liver Cancer Patients.7
198512962010Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.3
318370012020Discovery of rare coding variants in OGDHL and BRCA2 in relation to breast cancer risk in Chinese women.1

Citation

Dessen P

OGDHL (oxoglutarate dehydrogenase L)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53296/ogdhl