Atlas of Genetics and Cytogenetics in Oncology and Haematology


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OGG1 (8-oxoguanine DNA glycosylase)

Identity

Alias_symbol (synonym)HMMH
HOGG1
OGH1
MUTM
Other alias
HGNC (Hugo) OGG1
LocusID (NCBI) 4968
Atlas_Id 41606
Location 3p25.3  [Link to chromosome band 3p25]
Location_base_pair Starts at 9791628 and ends at 9799089 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FAM157B (9q34.3) / OGG1 (3p25.3)MTCH1 (6p21.2) / OGG1 (3p25.3)OGG1 (3p25.3) / CBX2 (17q25.3)
OGG1 (3p25.3) / EEF1D (8q24.3)OGG1 (3p25.3) / MTCH1 (6p21.2)OGG1 (3p25.3) / SLC38A2 (12q13.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Head and Neck: Laryngeal tumors: an overview


External links

Nomenclature
HGNC (Hugo)OGG1   8125
Cards
Entrez_Gene (NCBI)OGG1  4968  8-oxoguanine DNA glycosylase
AliasesHMMH; HOGG1; MUTM; OGH1
GeneCards (Weizmann)OGG1
Ensembl hg19 (Hinxton)ENSG00000114026 [Gene_View]  chr3:9791628-9799089 [Contig_View]  OGG1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000114026 [Gene_View]  chr3:9791628-9799089 [Contig_View]  OGG1 [Vega]
ICGC DataPortalENSG00000114026
TCGA cBioPortalOGG1
AceView (NCBI)OGG1
Genatlas (Paris)OGG1
WikiGenes4968
SOURCE (Princeton)OGG1
Genetics Home Reference (NIH)OGG1
Genomic and cartography
GoldenPath hg19 (UCSC)OGG1  -     chr3:9791628-9799089 +  3p25.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)OGG1  -     3p25.3   [Description]    (hg38-Dec_2013)
EnsemblOGG1 - 3p25.3 [CytoView hg19]  OGG1 - 3p25.3 [CytoView hg38]
Mapping of homologs : NCBIOGG1 [Mapview hg19]  OGG1 [Mapview hg38]
OMIM144700   601982   
Gene and transcription
Genbank (Entrez)AB000410 AB019528 AB019529 AB019530 AB019531
RefSeq transcript (Entrez)NM_002542 NM_016819 NM_016820 NM_016821 NM_016826 NM_016827 NM_016828 NM_016829
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_012106 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)OGG1
Cluster EST : UnigeneHs.380271 [ NCBI ]
CGAP (NCI)Hs.380271
Alternative Splicing GalleryENSG00000114026
Gene ExpressionOGG1 [ NCBI-GEO ]   OGG1 [ EBI - ARRAY_EXPRESS ]   OGG1 [ SEEK ]   OGG1 [ MEM ]
Gene Expression Viewer (FireBrowse)OGG1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4968
GTEX Portal (Tissue expression)OGG1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15527   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15527  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15527
Splice isoforms : SwissVarO15527
Catalytic activity : Enzyme3.2.2.- [ Enzyme-Expasy ]   3.2.2.-3.2.2.- [ IntEnz-EBI ]   3.2.2.- [ BRENDA ]   3.2.2.- [ KEGG ]   
PhosPhoSitePlusO15527
Domains : Interpro (EBI)DNA_glycosylase    HhH-GPD_domain    HTH_base_excis_C    Ogg1    OGG_N   
Domain families : Pfam (Sanger)HhH-GPD (PF00730)    OGG_N (PF07934)   
Domain families : Pfam (NCBI)pfam00730    pfam07934   
Domain families : Smart (EMBL)ENDO3c (SM00478)  
Conserved Domain (NCBI)OGG1
DMDM Disease mutations4968
Blocks (Seattle)OGG1
PDB (SRS)1EBM    1FN7    1HU0    1KO9    1LWV    1LWW    1LWY    1M3H    1M3Q    1N39    1N3A    1N3C    1YQK    1YQL    1YQM    1YQR    2I5W    2NOB    2NOE    2NOF    2NOH    2NOI    2NOL    2NOZ    2XHI    3IH7    3KTU   
PDB (PDBSum)1EBM    1FN7    1HU0    1KO9    1LWV    1LWW    1LWY    1M3H    1M3Q    1N39    1N3A    1N3C    1YQK    1YQL    1YQM    1YQR    2I5W    2NOB    2NOE    2NOF    2NOH    2NOI    2NOL    2NOZ    2XHI    3IH7    3KTU   
PDB (IMB)1EBM    1FN7    1HU0    1KO9    1LWV    1LWW    1LWY    1M3H    1M3Q    1N39    1N3A    1N3C    1YQK    1YQL    1YQM    1YQR    2I5W    2NOB    2NOE    2NOF    2NOH    2NOI    2NOL    2NOZ    2XHI    3IH7    3KTU   
PDB (RSDB)1EBM    1FN7    1HU0    1KO9    1LWV    1LWW    1LWY    1M3H    1M3Q    1N39    1N3A    1N3C    1YQK    1YQL    1YQM    1YQR    2I5W    2NOB    2NOE    2NOF    2NOH    2NOI    2NOL    2NOZ    2XHI    3IH7    3KTU   
Structural Biology KnowledgeBase1EBM    1FN7    1HU0    1KO9    1LWV    1LWW    1LWY    1M3H    1M3Q    1N39    1N3A    1N3C    1YQK    1YQL    1YQM    1YQR    2I5W    2NOB    2NOE    2NOF    2NOH    2NOI    2NOL    2NOZ    2XHI    3IH7    3KTU   
SCOP (Structural Classification of Proteins)1EBM    1FN7    1HU0    1KO9    1LWV    1LWW    1LWY    1M3H    1M3Q    1N39    1N3A    1N3C    1YQK    1YQL    1YQM    1YQR    2I5W    2NOB    2NOE    2NOF    2NOH    2NOI    2NOL    2NOZ    2XHI    3IH7    3KTU   
CATH (Classification of proteins structures)1EBM    1FN7    1HU0    1KO9    1LWV    1LWW    1LWY    1M3H    1M3Q    1N39    1N3A    1N3C    1YQK    1YQL    1YQM    1YQR    2I5W    2NOB    2NOE    2NOF    2NOH    2NOI    2NOL    2NOZ    2XHI    3IH7    3KTU   
SuperfamilyO15527
Human Protein AtlasENSG00000114026
Peptide AtlasO15527
HPRD03582
IPIIPI00007312   IPI00025730   IPI00220178   IPI00220179   IPI00220180   IPI00303869   IPI00026574   IPI00294126   IPI00477364   IPI00816589   IPI00926906   IPI00927740   IPI00927076   IPI01013811   IPI00925035   
Protein Interaction databases
DIP (DOE-UCLA)O15527
IntAct (EBI)O15527
FunCoupENSG00000114026
BioGRIDOGG1
STRING (EMBL)OGG1
ZODIACOGG1
Ontologies - Pathways
QuickGOO15527
Ontology : AmiGOacute inflammatory response  damaged DNA binding  endonuclease activity  protein binding  nucleus  nucleoplasm  nucleoplasm  mitochondrion  base-excision repair  regulation of transcription, DNA-templated  cellular response to DNA damage stimulus  response to oxidative stress  aging  microtubule binding  oxidized purine nucleobase lesion DNA N-glycosylase activity  response to radiation  response to light stimulus  nuclear matrix  nuclear speck  response to estradiol  oxidized purine DNA binding  regulation of protein import into nucleus, translocation  nucleotide-excision repair, DNA incision  8-oxo-7,8-dihydroguanine DNA N-glycosylase activity  response to drug  negative regulation of apoptotic process  protein complex  depurination  depyrimidination  response to ethanol  response to folic acid  cellular response to cadmium ion  negative regulation of double-strand break repair via single-strand annealing  
Ontology : EGO-EBIacute inflammatory response  damaged DNA binding  endonuclease activity  protein binding  nucleus  nucleoplasm  nucleoplasm  mitochondrion  base-excision repair  regulation of transcription, DNA-templated  cellular response to DNA damage stimulus  response to oxidative stress  aging  microtubule binding  oxidized purine nucleobase lesion DNA N-glycosylase activity  response to radiation  response to light stimulus  nuclear matrix  nuclear speck  response to estradiol  oxidized purine DNA binding  regulation of protein import into nucleus, translocation  nucleotide-excision repair, DNA incision  8-oxo-7,8-dihydroguanine DNA N-glycosylase activity  response to drug  negative regulation of apoptotic process  protein complex  depurination  depyrimidination  response to ethanol  response to folic acid  cellular response to cadmium ion  negative regulation of double-strand break repair via single-strand annealing  
Pathways : KEGGBase excision repair   
NDEx NetworkOGG1
Atlas of Cancer Signalling NetworkOGG1
Wikipedia pathwaysOGG1
Orthology - Evolution
OrthoDB4968
GeneTree (enSembl)ENSG00000114026
Phylogenetic Trees/Animal Genes : TreeFamOGG1
HOVERGENO15527
HOGENOMO15527
Homologs : HomoloGeneOGG1
Homology/Alignments : Family Browser (UCSC)OGG1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOGG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OGG1
dbVarOGG1
ClinVarOGG1
1000_GenomesOGG1 
Exome Variant ServerOGG1
ExAC (Exome Aggregation Consortium)OGG1 (select the gene name)
Genetic variants : HAPMAP4968
Genomic Variants (DGV)OGG1 [DGVbeta]
DECIPHER (Syndromes)3:9791628-9799089  ENSG00000114026
CONAN: Copy Number AnalysisOGG1 
Mutations
ICGC Data PortalOGG1 
TCGA Data PortalOGG1 
Broad Tumor PortalOGG1
OASIS PortalOGG1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOGG1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOGG1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch OGG1
DgiDB (Drug Gene Interaction Database)OGG1
DoCM (Curated mutations)OGG1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OGG1 (select a term)
intoGenOGG1
Cancer3DOGG1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM144700    601982   
Orphanet
MedgenOGG1
Genetic Testing Registry OGG1
NextProtO15527 [Medical]
TSGene4968
GENETestsOGG1
Huge Navigator OGG1 [HugePedia]
snp3D : Map Gene to Disease4968
BioCentury BCIQOGG1
ClinGenOGG1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4968
Chemical/Pharm GKB GenePA31912
Clinical trialOGG1
Miscellaneous
canSAR (ICR)OGG1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOGG1
EVEXOGG1
GoPubMedOGG1
iHOPOGG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:13:02 CEST 2017

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