OGG1 (8-oxoguanine DNA glycosylase)

2003-02-01  

Identity

HGNC
LOCATION
3p25.3
LOCUSID
ALIAS
HMMH,HOGG1,MUTM,OGH1
FUSION GENES

Other Information

Locus ID:

NCBI: 4968
MIM: 601982
HGNC: 8125
Ensembl: ENSG00000114026

Variants:

dbSNP: 4968
ClinVar: 4968
TCGA: ENSG00000114026
COSMIC: OGG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114026ENST00000302003O15527
ENSG00000114026ENST00000302003E5KPN0
ENSG00000114026ENST00000302008O15527
ENSG00000114026ENST00000302008E5KPM7
ENSG00000114026ENST00000302036O15527
ENSG00000114026ENST00000302036E5KPM5
ENSG00000114026ENST00000339511O15527
ENSG00000114026ENST00000344629O15527
ENSG00000114026ENST00000344629E5KPN1
ENSG00000114026ENST00000349503O15527
ENSG00000114026ENST00000349503E5KPM6
ENSG00000114026ENST00000352937H7BXZ1
ENSG00000114026ENST00000383826O15527
ENSG00000114026ENST00000383826E5KPM8
ENSG00000114026ENST00000416333H7C1V7
ENSG00000114026ENST00000425665F8WCZ9
ENSG00000114026ENST00000426518H7C1D7
ENSG00000114026ENST00000429146H7C0A1
ENSG00000114026ENST00000441094H7BZM3
ENSG00000114026ENST00000449570O15527
ENSG00000114026ENST00000449570E5KPM9

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
Base excision repairKEGGhsa03410
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Base-Excision Repair, AP Site FormationREACTOMER-HSA-73929
DepurinationREACTOMER-HSA-73927
Recognition and association of DNA glycosylase with site containing an affected purineREACTOMER-HSA-110330
Cleavage of the damaged purineREACTOMER-HSA-110331
DepyrimidinationREACTOMER-HSA-73928
Recognition and association of DNA glycosylase with site containing an affected pyrimidineREACTOMER-HSA-110328
Cleavage of the damaged pyrimidineREACTOMER-HSA-110329
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
Displacement of DNA glycosylase by APEX1REACTOMER-HSA-110357
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement PathwayREACTOMER-HSA-5649702

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalVariantAnnotationnot associatedPD28796378
PA164713176Platinum compoundsChemicalVariantAnnotationnot associatedPD28796378
PA166122986radiotherapyChemicalVariantAnnotationnot associatedPD28796378
PA445742Stomach NeoplasmsDiseaseVariantAnnotationnot associatedPD28796378

References

Pubmed IDYearTitleCitations
165855172006A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA.211
158006162005Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA.126
162218082005Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review.120
162218082005Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review.120
161952372006Polymorphisms of DNA repair genes and risk of non-small cell lung cancer.112
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
164789872006Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo.74
166090222006Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer.71
129338152003Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1.69
191163882009A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.63

Citation

Dessen P

OGG1 (8-oxoguanine DNA glycosylase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41606/ogg1