OGN (osteoglycin)

2003-12-01  

Identity

HGNC
LOCATION
9q22.31
LOCUSID
ALIAS
OG,OIF,SLRR3A

Other Information

Locus ID:

NCBI: 4969
MIM: 602383
HGNC: 8126
Ensembl: ENSG00000106809

Variants:

dbSNP: 4969
ClinVar: 4969
TCGA: ENSG00000106809
COSMIC: OGN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106809ENST00000262551P20774
ENSG00000106809ENST00000262551A8K0R3
ENSG00000106809ENST00000375561P20774
ENSG00000106809ENST00000375561A8K0R3
ENSG00000106809ENST00000447356Q5TBF5

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Diseases associated with glycosaminoglycan metabolismREACTOMER-HSA-3560782
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)REACTOMER-HSA-3656244
Defective CHST6 causes MCDC1REACTOMER-HSA-3656225
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Keratan sulfate/keratin metabolismREACTOMER-HSA-1638074
Keratan sulfate biosynthesisREACTOMER-HSA-2022854
Keratan sulfate degradationREACTOMER-HSA-2022857
Defective ST3GAL3 causes MCT12 and EIEE15REACTOMER-HSA-3656243

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
292623492017Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.31
178955232007Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study.30
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
246516812014Circulating osteoglycin and NGAL/MMP9 complex concentrations predict 1-year major adverse cardiovascular events after coronary angiography.13
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
294997652018Osteoglycin (OGN) reverses epithelial to mesenchymal transition and invasiveness in colorectal cancer via EGFR/Akt pathway.8
182436072008Expression studies of osteoglycin/mimecan (OGN) in the cochlea and auditory phenotype of Ogn-deficient mice.7
237142412013Enhancement of IGF-2-induced neurite outgrowth by IGF-binding protein-2 and osteoglycin in SH-SY5Y human neuroblastoma cells.7

Citation

Dessen P

OGN (osteoglycin)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41607/ogn