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OGT (O-linked N-acetylglucosamine (GlcNAc) transferase)

Identity

Other namesHINCUT-1
HRNT1
O-GLCNAC
HGNC (Hugo) OGT
LocusID (NCBI) 8473
Atlas_Id 51541
Location Xq13.1  [Link to chromosome band Xq13]
Location_base_pair Starts at 70752912 and ends at 70795747 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADD3 (10q25.1) / OGT (Xq13.1)HLA-B (6p21.33) / OGT (Xq13.1)OGT (Xq13.1) / ACTB (7p22.1)
OGT (Xq13.1) / POLA1 (Xp22.11)SLC9A7 (Xp11.23) / OGT (Xq13.1)ADD3 10q25.1 / OGT Xq13.1
OGT Xq13.1 / POLA1 Xp22.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OGT   8127
Cards
Entrez_Gene (NCBI)OGT  8473  O-linked N-acetylglucosamine (GlcNAc) transferase
AliasesHINCUT-1; HRNT1; O-GLCNAC
GeneCards (Weizmann)OGT
Ensembl hg19 (Hinxton)ENSG00000147162 [Gene_View]  chrX:70752912-70795747 [Contig_View]  OGT [Vega]
Ensembl hg38 (Hinxton)ENSG00000147162 [Gene_View]  chrX:70752912-70795747 [Contig_View]  OGT [Vega]
ICGC DataPortalENSG00000147162
TCGA cBioPortalOGT
AceView (NCBI)OGT
Genatlas (Paris)OGT
WikiGenes8473
SOURCE (Princeton)OGT
Genomic and cartography
GoldenPath hg19 (UCSC)OGT  -     chrX:70752912-70795747 +  Xq13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)OGT  -     Xq13.1   [Description]    (hg38-Dec_2013)
EnsemblOGT - Xq13.1 [CytoView hg19]  OGT - Xq13.1 [CytoView hg38]
Mapping of homologs : NCBIOGT [Mapview hg19]  OGT [Mapview hg38]
OMIM300255   
Gene and transcription
Genbank (Entrez)AF070560 AF147394 AF223393 AK300267 AK313530
RefSeq transcript (Entrez)NM_003605 NM_181672 NM_181673
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_015875 NT_011651 NW_004929443
Consensus coding sequences : CCDS (NCBI)OGT
Cluster EST : UnigeneHs.405410 [ NCBI ]
CGAP (NCI)Hs.405410
Alternative Splicing GalleryENSG00000147162
Gene ExpressionOGT [ NCBI-GEO ]   OGT [ EBI - ARRAY_EXPRESS ]   OGT [ SEEK ]   OGT [ MEM ]
Gene Expression Viewer (FireBrowse)OGT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8473
GTEX Portal (Tissue expression)OGT
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15294 (Uniprot)
NextProtO15294  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15294
Splice isoforms : SwissVarO15294 (Swissvar)
PhosPhoSitePlusO15294
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)OGT/SEC/SPY_C    TPR-contain_dom    TPR-like_helical_dom    TPR_1    TPR_repeat   
Domain families : Pfam (Sanger)Glyco_transf_41 (PF13844)    TPR_1 (PF00515)    TPR_11 (PF13414)   
Domain families : Pfam (NCBI)pfam13844    pfam00515    pfam13414   
Domain families : Smart (EMBL)TPR (SM00028)  
DMDM Disease mutations8473
Blocks (Seattle)OGT
PDB (SRS)1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C    4XI9    4XIF    5BNW    5C1D   
PDB (PDBSum)1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C    4XI9    4XIF    5BNW    5C1D   
PDB (IMB)1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C    4XI9    4XIF    5BNW    5C1D   
PDB (RSDB)1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C    4XI9    4XIF    5BNW    5C1D   
Structural Biology KnowledgeBase1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C    4XI9    4XIF    5BNW    5C1D   
SCOP (Structural Classification of Proteins)1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C    4XI9    4XIF    5BNW    5C1D   
CATH (Classification of proteins structures)1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C    4XI9    4XIF    5BNW    5C1D   
SuperfamilyO15294
Human Protein AtlasENSG00000147162
Peptide AtlasO15294
HPRD02222
IPIIPI00005780   IPI00219856   IPI00607723   IPI01008950   IPI00924555   IPI00924749   
Protein Interaction databases
DIP (DOE-UCLA)O15294
IntAct (EBI)O15294
FunCoupENSG00000147162
BioGRIDOGT
STRING (EMBL)OGT
ZODIACOGT
Ontologies - Pathways
QuickGOO15294
Ontology : AmiGOhistone acetyltransferase complex  euchromatin  positive regulation of protein phosphorylation  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  nucleoplasm  mitochondrion  cytosol  plasma membrane  glucosamine metabolic process  regulation of glycolytic process  protein O-linked glycosylation  protein O-linked glycosylation  apoptotic process  signal transduction  response to nutrient  enzyme activator activity  transcription factor binding  acetylglucosaminyltransferase activity  negative regulation of peptidyl-threonine phosphorylation  protein N-acetylglucosaminyltransferase activity  protein domain specific binding  positive regulation of granulocyte differentiation  forebrain development  negative regulation of protein ubiquitination  response to insulin  cellular response to insulin stimulus  circadian regulation of gene expression  negative regulation of peptidyl-serine phosphorylation  regulation of Rac protein signal transduction  peptide binding  zymogen granule  neuron projection  neuronal cell body  positive regulation of catalytic activity  histone H4-K5 acetylation  histone H4-K8 acetylation  histone H4-K16 acetylation  histone acetyltransferase activity (H4-K5 specific)  histone acetyltransferase activity (H4-K8 specific)  positive regulation of cell size  positive regulation of proteolysis  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  regulation of insulin receptor signaling pathway  histone acetyltransferase activity (H4-K16 specific)  phosphatidylinositol-mediated signaling  monosaccharide binding  intracellular distribution of mitochondria  positive regulation of histone H3-K4 methylation  negative regulation of cell death  positive regulation of histone H3-K27 methylation  protein homotrimerization  protein heterotrimerization  MLL5-L complex  cellular response to lipopolysaccharide  cellular response to retinoic acid  cellular response to glucose stimulus  histone H3-K4 trimethylation  negative regulation of protein targeting to membrane  regulation of gluconeogenesis involved in cellular glucose homeostasis  cellular response to toxic substance  protein O-GlcNAc transferase activity  protein O-GlcNAc transferase activity  negative regulation of cellular response to hypoxia  positive regulation of protein localization to nucleus  positive regulation of reactive oxygen species biosynthetic process  
Ontology : EGO-EBIhistone acetyltransferase complex  euchromatin  positive regulation of protein phosphorylation  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  nucleoplasm  mitochondrion  cytosol  plasma membrane  glucosamine metabolic process  regulation of glycolytic process  protein O-linked glycosylation  protein O-linked glycosylation  apoptotic process  signal transduction  response to nutrient  enzyme activator activity  transcription factor binding  acetylglucosaminyltransferase activity  negative regulation of peptidyl-threonine phosphorylation  protein N-acetylglucosaminyltransferase activity  protein domain specific binding  positive regulation of granulocyte differentiation  forebrain development  negative regulation of protein ubiquitination  response to insulin  cellular response to insulin stimulus  circadian regulation of gene expression  negative regulation of peptidyl-serine phosphorylation  regulation of Rac protein signal transduction  peptide binding  zymogen granule  neuron projection  neuronal cell body  positive regulation of catalytic activity  histone H4-K5 acetylation  histone H4-K8 acetylation  histone H4-K16 acetylation  histone acetyltransferase activity (H4-K5 specific)  histone acetyltransferase activity (H4-K8 specific)  positive regulation of cell size  positive regulation of proteolysis  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  regulation of insulin receptor signaling pathway  histone acetyltransferase activity (H4-K16 specific)  phosphatidylinositol-mediated signaling  monosaccharide binding  intracellular distribution of mitochondria  positive regulation of histone H3-K4 methylation  negative regulation of cell death  positive regulation of histone H3-K27 methylation  protein homotrimerization  protein heterotrimerization  MLL5-L complex  cellular response to lipopolysaccharide  cellular response to retinoic acid  cellular response to glucose stimulus  histone H3-K4 trimethylation  negative regulation of protein targeting to membrane  regulation of gluconeogenesis involved in cellular glucose homeostasis  cellular response to toxic substance  protein O-GlcNAc transferase activity  protein O-GlcNAc transferase activity  negative regulation of cellular response to hypoxia  positive regulation of protein localization to nucleus  positive regulation of reactive oxygen species biosynthetic process  
Pathways : KEGGOther types of O-glycan biosynthesis   
NDEx NetworkOGT
Atlas of Cancer Signalling NetworkOGT
Wikipedia pathwaysOGT
Orthology - Evolution
OrthoDB8473
GeneTree (enSembl)ENSG00000147162
Phylogenetic Trees/Animal Genes : TreeFamOGT
Homologs : HomoloGeneOGT
Homology/Alignments : Family Browser (UCSC)OGT
Gene fusions - Rearrangements
Fusion: TCGAADD3 10q25.1 OGT Xq13.1 LGG
Fusion: TCGAOGT Xq13.1 POLA1 Xp22.11 PRAD
Polymorphisms : SNP, variants
NCBI Variation ViewerOGT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OGT
dbVarOGT
ClinVarOGT
1000_GenomesOGT 
Exome Variant ServerOGT
ExAC (Exome Aggregation Consortium)OGT (select the gene name)
Genetic variants : HAPMAP8473
Genomic Variants (DGV)OGT [DGVbeta]
Mutations
ICGC Data PortalOGT 
TCGA Data PortalOGT 
Broad Tumor PortalOGT
OASIS PortalOGT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOGT 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch OGT
DgiDB (Drug Gene Interaction Database)OGT
DoCM (Curated mutations)OGT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OGT (select a term)
intoGenOGT
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)X:70752912-70795747  ENSG00000147162
CONAN: Copy Number AnalysisOGT 
Mutations and Diseases : HGMDOGT
OMIM300255   
MedgenOGT
Genetic Testing Registry OGT
NextProtO15294 [Medical]
TSGene8473
GENETestsOGT
Huge Navigator OGT [HugePedia]
snp3D : Map Gene to Disease8473
BioCentury BCIQOGT
ClinGenOGT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8473
Chemical/Pharm GKB GenePA31914
Clinical trialOGT
Miscellaneous
canSAR (ICR)OGT (select the gene name)
Probes
Litterature
PubMed137 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOGT
EVEXOGT
GoPubMedOGT
iHOPOGT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 19:05:38 CEST 2016

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