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OGT (O-linked N-acetylglucosamine (GlcNAc) transferase)

Identity

Alias_namesO-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
Alias_symbol (synonym)O-GLCNAC
HRNT1
MGC22921
FLJ23071
Other aliasHINCUT-1
HGNC (Hugo) OGT
LocusID (NCBI) 8473
Atlas_Id 51541
Location Xq13.1  [Link to chromosome band Xq13]
Location_base_pair Starts at 71533062 and ends at 71575897 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADD3 (10q25.1) / OGT (Xq13.1)HLA-B (6p21.33) / OGT (Xq13.1)OGT (Xq13.1) / ACTB (7p22.1)
OGT (Xq13.1) / POLA1 (Xp22.11)SLC9A7 (Xp11.23) / OGT (Xq13.1)ADD3 10q25.1 / OGT Xq13.1
OGT Xq13.1 / POLA1 Xp22.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OGT   8127
Cards
Entrez_Gene (NCBI)OGT  8473  O-linked N-acetylglucosamine (GlcNAc) transferase
AliasesHINCUT-1; HRNT1; O-GLCNAC
GeneCards (Weizmann)OGT
Ensembl hg19 (Hinxton)ENSG00000147162 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147162 [Gene_View]  chrX:71533062-71575897 [Contig_View]  OGT [Vega]
ICGC DataPortalENSG00000147162
TCGA cBioPortalOGT
AceView (NCBI)OGT
Genatlas (Paris)OGT
WikiGenes8473
SOURCE (Princeton)OGT
Genetics Home Reference (NIH)OGT
Genomic and cartography
GoldenPath hg38 (UCSC)OGT  -     chrX:71533062-71575897 +  Xq13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OGT  -     Xq13.1   [Description]    (hg19-Feb_2009)
EnsemblOGT - Xq13.1 [CytoView hg19]  OGT - Xq13.1 [CytoView hg38]
Mapping of homologs : NCBIOGT [Mapview hg19]  OGT [Mapview hg38]
OMIM300255   
Gene and transcription
Genbank (Entrez)AF070560 AF147394 AF223393 AK300267 AK313530
RefSeq transcript (Entrez)NM_003605 NM_181672 NM_181673
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OGT
Cluster EST : UnigeneHs.405410 [ NCBI ]
CGAP (NCI)Hs.405410
Alternative Splicing GalleryENSG00000147162
Gene ExpressionOGT [ NCBI-GEO ]   OGT [ EBI - ARRAY_EXPRESS ]   OGT [ SEEK ]   OGT [ MEM ]
Gene Expression Viewer (FireBrowse)OGT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8473
GTEX Portal (Tissue expression)OGT
Human Protein AtlasENSG00000147162-OGT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15294   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15294  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15294
Splice isoforms : SwissVarO15294
PhosPhoSitePlusO15294
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)OGT/SEC/SPY_C    TPR-contain_dom    TPR-like_helical_dom    TPR_1    TPR_repeat   
Domain families : Pfam (Sanger)Glyco_transf_41 (PF13844)    TPR_1 (PF00515)    TPR_11 (PF13414)    TPR_8 (PF13181)   
Domain families : Pfam (NCBI)pfam13844    pfam00515    pfam13414    pfam13181   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)OGT
DMDM Disease mutations8473
Blocks (Seattle)OGT
PDB (SRS)1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C    4XI9    4XIF    5BNW    5C1D    5HGV   
PDB (PDBSum)1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C    4XI9    4XIF    5BNW    5C1D    5HGV   
PDB (IMB)1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C    4XI9    4XIF    5BNW    5C1D    5HGV   
PDB (RSDB)1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C    4XI9    4XIF    5BNW    5C1D    5HGV   
Structural Biology KnowledgeBase1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C    4XI9    4XIF    5BNW    5C1D    5HGV   
SCOP (Structural Classification of Proteins)1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C    4XI9    4XIF    5BNW    5C1D    5HGV   
CATH (Classification of proteins structures)1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C    4XI9    4XIF    5BNW    5C1D    5HGV   
SuperfamilyO15294
Human Protein Atlas [tissue]ENSG00000147162-OGT [tissue]
Peptide AtlasO15294
HPRD02222
IPIIPI00005780   IPI00219856   IPI00607723   IPI01008950   IPI00924555   IPI00924749   
Protein Interaction databases
DIP (DOE-UCLA)O15294
IntAct (EBI)O15294
FunCoupENSG00000147162
BioGRIDOGT
STRING (EMBL)OGT
ZODIACOGT
Ontologies - Pathways
QuickGOO15294
Ontology : AmiGOhistone acetyltransferase complex  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  nucleoplasm  nucleoplasm  mitochondrion  cytosol  plasma membrane  regulation of glycolytic process  protein O-linked glycosylation  protein O-linked glycosylation  apoptotic process  signal transduction  response to nutrient  acetylglucosaminyltransferase activity  protein N-acetylglucosaminyltransferase activity  protein deubiquitination  negative regulation of protein ubiquitination  response to insulin  circadian regulation of gene expression  regulation of Rac protein signal transduction  histone H4-K5 acetylation  histone H4-K8 acetylation  histone H4-K16 acetylation  histone acetyltransferase activity (H4-K5 specific)  histone acetyltransferase activity (H4-K8 specific)  positive regulation of proteolysis  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  regulation of insulin receptor signaling pathway  histone acetyltransferase activity (H4-K16 specific)  phosphatidylinositol-mediated signaling  positive regulation of histone H3-K27 methylation  histone H3-K4 trimethylation  regulation of gluconeogenesis involved in cellular glucose homeostasis  protein O-GlcNAc transferase activity  protein O-GlcNAc transferase activity  
Ontology : EGO-EBIhistone acetyltransferase complex  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  nucleoplasm  nucleoplasm  mitochondrion  cytosol  plasma membrane  regulation of glycolytic process  protein O-linked glycosylation  protein O-linked glycosylation  apoptotic process  signal transduction  response to nutrient  acetylglucosaminyltransferase activity  protein N-acetylglucosaminyltransferase activity  protein deubiquitination  negative regulation of protein ubiquitination  response to insulin  circadian regulation of gene expression  regulation of Rac protein signal transduction  histone H4-K5 acetylation  histone H4-K8 acetylation  histone H4-K16 acetylation  histone acetyltransferase activity (H4-K5 specific)  histone acetyltransferase activity (H4-K8 specific)  positive regulation of proteolysis  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  regulation of insulin receptor signaling pathway  histone acetyltransferase activity (H4-K16 specific)  phosphatidylinositol-mediated signaling  positive regulation of histone H3-K27 methylation  histone H3-K4 trimethylation  regulation of gluconeogenesis involved in cellular glucose homeostasis  protein O-GlcNAc transferase activity  protein O-GlcNAc transferase activity  
Pathways : KEGGOther types of O-glycan biosynthesis   
NDEx NetworkOGT
Atlas of Cancer Signalling NetworkOGT
Wikipedia pathwaysOGT
Orthology - Evolution
OrthoDB8473
GeneTree (enSembl)ENSG00000147162
Phylogenetic Trees/Animal Genes : TreeFamOGT
HOVERGENO15294
HOGENOMO15294
Homologs : HomoloGeneOGT
Homology/Alignments : Family Browser (UCSC)OGT
Gene fusions - Rearrangements
Fusion : MitelmanADD3/OGT [10q25.1/Xq13.1]  [t(X;10)(q13;q25)]  
Fusion : MitelmanOGT/ACTB [Xq13.1/7p22.1]  [t(X;7)(q13;p22)]  
Fusion : MitelmanOGT/POLA1 [Xq13.1/Xp22.11]  [t(X;X)(p22;q13)]  
Fusion: TCGA_MDACCADD3 10q25.1 OGT Xq13.1 LGG
Fusion: TCGA_MDACCOGT Xq13.1 POLA1 Xp22.11 PRAD
Tumor Fusion PortalOGT
Fusion Cancer (Beijing)HLA-B [6p21.33]  -  OGT [Xq13.1]  [FUSC000442]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOGT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OGT
dbVarOGT
ClinVarOGT
1000_GenomesOGT 
Exome Variant ServerOGT
ExAC (Exome Aggregation Consortium)ENSG00000147162
GNOMAD BrowserENSG00000147162
Genetic variants : HAPMAP8473
Genomic Variants (DGV)OGT [DGVbeta]
DECIPHEROGT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOGT 
Mutations
ICGC Data PortalOGT 
TCGA Data PortalOGT 
Broad Tumor PortalOGT
OASIS PortalOGT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOGT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOGT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch OGT
DgiDB (Drug Gene Interaction Database)OGT
DoCM (Curated mutations)OGT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OGT (select a term)
intoGenOGT
Cancer3DOGT(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300255   
Orphanet
DisGeNETOGT
MedgenOGT
Genetic Testing Registry OGT
NextProtO15294 [Medical]
TSGene8473
GENETestsOGT
Target Öalid!timnOGT
Huge Navigator OGT [HugePedia]
snp3D : Map Gene to Disease8473
BioCentury BCIQOGT
ClinGenOGT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8473
Chemical/Pharm GKB GenePA31914
Clinical trialOGT
Miscellaneous
canSAR (ICR)OGT (select the gene name)
Probes
Litterature
PubMed155 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOGT
EVEXOGT
GoPubMedOGT
iHOPOGT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Nov 20 20:50:41 CET 2017

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