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OGT (O-linked N-acetylglucosamine (GlcNAc) transferase)

Identity

Other namesHRNT1
O-GLCNAC
HGNC (Hugo) OGT
LocusID (NCBI) 8473
Location Xq13.1
Location_base_pair Starts at 70752912 and ends at 70795747 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)OGT   8127
Cards
Entrez_Gene (NCBI)OGT  8473  O-linked N-acetylglucosamine (GlcNAc) transferase
GeneCards (Weizmann)OGT
Ensembl (Hinxton)ENSG00000147162 [Gene_View]  chrX:70752912-70795747 [Contig_View]  OGT [Vega]
ICGC DataPortalENSG00000147162
AceView (NCBI)OGT
Genatlas (Paris)OGT
WikiGenes8473
SOURCE (Princeton)NM_003605 NM_181672 NM_181673
Genomic and cartography
GoldenPath (UCSC)OGT  -  Xq13.1   chrX:70752912-70795747 +  Xq13.1   [Description]    (hg19-Feb_2009)
EnsemblOGT - Xq13.1 [CytoView]
Mapping of homologs : NCBIOGT [Mapview]
OMIM300255   
Gene and transcription
Genbank (Entrez)AF070560 AF147394 AF223393 AK300267 AK313530
RefSeq transcript (Entrez)NM_003605 NM_181672 NM_181673
RefSeq genomic (Entrez)AC_000155 NC_000023 NC_018934 NG_015875 NT_011651 NW_001842373 NW_004929443
Consensus coding sequences : CCDS (NCBI)OGT
Cluster EST : UnigeneHs.405410 [ NCBI ]
CGAP (NCI)Hs.405410
Alternative Splicing : Fast-db (Paris)GSHG0031613
Alternative Splicing GalleryENSG00000147162
Gene ExpressionOGT [ NCBI-GEO ]     OGT [ SEEK ]   OGT [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15294 (Uniprot)
NextProtO15294  [Medical]
With graphics : InterProO15294
Splice isoforms : SwissVarO15294 (Swissvar)
Catalytic activity : Enzyme2.4.1.255 [ Enzyme-Expasy ]   2.4.1.2552.4.1.255 [ IntEnz-EBI ]   2.4.1.255 [ BRENDA ]   2.4.1.255 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)OGT/SEC/SPY_C    TPR-contain_dom    TPR-like_helical    TPR_1    TPR_repeat   
Related proteins : CluSTrO15294
Domain families : Pfam (Sanger)Glyco_transf_41 (PF13844)    TPR_1 (PF00515)   
Domain families : Pfam (NCBI)pfam13844    pfam00515   
Domain families : Smart (EMBL)TPR (SM00028)  
DMDM Disease mutations8473
Blocks (Seattle)O15294
PDB (SRS)1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C   
PDB (PDBSum)1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C   
PDB (IMB)1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C   
PDB (RSDB)1W3B    3PE3    3PE4    3TAX    4AY5    4AY6    4CDR    4GYW    4GYY    4GZ3    4GZ5    4GZ6    4N39    4N3A    4N3B    4N3C   
Human Protein AtlasENSG00000147162
Peptide AtlasO15294
HPRD02222
IPIIPI00005780   IPI00219856   IPI00607723   IPI01008950   IPI00924555   IPI00924749   
Protein Interaction databases
DIP (DOE-UCLA)O15294
IntAct (EBI)O15294
FunCoupENSG00000147162
BioGRIDOGT
InParanoidO15294
Interologous Interaction database O15294
IntegromeDBOGT
STRING (EMBL)OGT
Ontologies - Pathways
Ontology : AmiGOhistone acetyltransferase complex  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrion  microtubule organizing center  cytosol  plasma membrane  regulation of glycolytic process  chromatin organization  protein O-linked glycosylation  protein O-linked glycosylation  apoptotic process  signal transduction  response to nutrient  enzyme activator activity  acetylglucosaminyltransferase activity  protein N-acetylglucosaminyltransferase activity  positive regulation of granulocyte differentiation  negative regulation of protein ubiquitination  response to insulin  circadian regulation of gene expression  regulation of Rac protein signal transduction  positive regulation of catalytic activity  histone H4-K5 acetylation  histone H4-K8 acetylation  histone H4-K16 acetylation  histone acetyltransferase activity (H4-K5 specific)  histone acetyltransferase activity (H4-K8 specific)  positive regulation of proteolysis  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  regulation of insulin receptor signaling pathway  histone acetyltransferase activity (H4-K16 specific)  phosphatidylinositol-mediated signaling  positive regulation of histone H3-K4 methylation  positive regulation of histone H3-K27 methylation  MLL5-L complex  cellular response to retinoic acid  histone H3-K4 trimethylation  regulation of gluconeogenesis involved in cellular glucose homeostasis  protein O-GlcNAc transferase activity  
Ontology : EGO-EBIhistone acetyltransferase complex  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrion  microtubule organizing center  cytosol  plasma membrane  regulation of glycolytic process  chromatin organization  protein O-linked glycosylation  protein O-linked glycosylation  apoptotic process  signal transduction  response to nutrient  enzyme activator activity  acetylglucosaminyltransferase activity  protein N-acetylglucosaminyltransferase activity  positive regulation of granulocyte differentiation  negative regulation of protein ubiquitination  response to insulin  circadian regulation of gene expression  regulation of Rac protein signal transduction  positive regulation of catalytic activity  histone H4-K5 acetylation  histone H4-K8 acetylation  histone H4-K16 acetylation  histone acetyltransferase activity (H4-K5 specific)  histone acetyltransferase activity (H4-K8 specific)  positive regulation of proteolysis  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  regulation of insulin receptor signaling pathway  histone acetyltransferase activity (H4-K16 specific)  phosphatidylinositol-mediated signaling  positive regulation of histone H3-K4 methylation  positive regulation of histone H3-K27 methylation  MLL5-L complex  cellular response to retinoic acid  histone H3-K4 trimethylation  regulation of gluconeogenesis involved in cellular glucose homeostasis  protein O-GlcNAc transferase activity  
Pathways : KEGGOther types of O-glycan biosynthesis   
Protein Interaction DatabaseOGT
Wikipedia pathwaysOGT
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)OGT
SNP (GeneSNP Utah)OGT
SNP : HGBaseOGT
Genetic variants : HAPMAPOGT
1000_GenomesOGT 
ICGC programENSG00000147162 
CONAN: Copy Number AnalysisOGT 
Somatic Mutations in Cancer : COSMICOGT 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
Mutations and Diseases : HGMDOGT
OMIM300255   
MedgenOGT
GENETestsOGT
Disease Genetic AssociationOGT
Huge Navigator OGT [HugePedia]  OGT [HugeCancerGEM]
Genomic VariantsOGT  OGT [DGVbeta]
Exome VariantOGT
dbVarOGT
ClinVarOGT
snp3D : Map Gene to Disease8473
General knowledge
Homologs : HomoloGeneOGT
Homology/Alignments : Family Browser (UCSC)OGT
Phylogenetic Trees/Animal Genes : TreeFamOGT
Chemical/Protein Interactions : CTD8473
Chemical/Pharm GKB GenePA31914
Clinical trialOGT
Cancer Resource (Charite)ENSG00000147162
Other databases
Probes
Litterature
PubMed116 Pubmed reference(s) in Entrez
CoreMineOGT
iHOPOGT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 13:05:52 CEST 2014

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