OIP5 (Opa interacting protein 5)

2010-09-01  

Identity

HGNC
LOCATION
15q15.1
LOCUSID
ALIAS
5730547N13Rik,CT86,LINT-25,MIS18B,MIS18beta,hMIS18beta
FUSION GENES

Other Information

Locus ID:

NCBI: 11339
MIM: 606020
HGNC: 20300
Ensembl: ENSG00000104147

Variants:

dbSNP: 11339
ClinVar: 11339
TCGA: ENSG00000104147
COSMIC: OIP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104147ENST00000220514O43482
ENSG00000104147ENST00000220514A0A024R9N0
ENSG00000104147ENST00000560640H0YKL4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Chromosome MaintenanceREACTOMER-HSA-73886
Nucleosome assemblyREACTOMER-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromereREACTOMER-HSA-606279

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
171990382007Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1.158
245199342014Mitotic regulator Mis18β interacts with and specifies the centromeric assembly of molecular chaperone holliday junction recognition protein (HJURP).33
269426802016Licensing of Centromeric Chromatin Assembly through the Mis18α-Mis18β Heterotetramer.29
272390452016Differential Binding Partners of the Mis18α/β YIPPEE Domains Regulate Mis18 Complex Recruitment to Centromeres.18
280597022017CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading.16
292479492018Long non-coding RNA OIP5-AS1 functions as an oncogene in lung adenocarcinoma through targeting miR-448/Bcl-2.16
297733442018LncRNA OIP5-AS1 regulates radioresistance by targeting DYRK1A through miR-369-3p in colorectal cancer cells.16
205100192010OIP5 is a highly expressed potential therapeutic target for colorectal and gastric cancers.15
281840242017OIP5, a target of miR-15b-5p, regulates hepatocellular carcinoma growth and metastasis through the AKT/mTORC1 and β-catenin signaling pathways.14
221290942012Characterization of an Opa interacting protein 5 involved in lung and esophageal carcinogenesis.13

Citation

Dessen P

OIP5 (Opa interacting protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2010-09-01

Online version: http://atlasgeneticsoncology.org/gene/51671/oip5