Atlas of Genetics and Cytogenetics in Oncology and Haematology

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OLR1 (oxidized low density lipoprotein receptor 1)

Identity

Alias (NCBI)CLEC8A
LOX1
LOXIN
SCARE1
SLOX1
HGNC (Hugo) OLR1
HGNC Alias symbLOX-1
SCARE1
CLEC8A
HGNC Previous nameoxidised low density lipoprotein (lectin-like) receptor 1
LocusID (NCBI) 4973
Atlas_Id 52401
Location 12p13.2  [Link to chromosome band 12p13]
Location_base_pair Starts at 10158301 and ends at 10172132 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
OLR1 (12p13.2) / EPS15L1 (19p13.11)XIAP (Xq25) / OLR1 (12p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(X;12)(q25;p13) OLR1/XIAP
t(X;12)(q25;p13) XIAP/OLR1

External links

Nomenclature
HGNC (Hugo)OLR1   8133
Cards
Entrez_Gene (NCBI)OLR1    oxidized low density lipoprotein receptor 1
AliasesCLEC8A; LOX1; LOXIN; SCARE1; 
SLOX1
GeneCards (Weizmann)OLR1
Ensembl hg19 (Hinxton)ENSG00000173391 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173391 [Gene_View]  ENSG00000173391 [Sequence]  chr12:10158301-10172132 [Contig_View]  OLR1 [Vega]
ICGC DataPortalENSG00000173391
TCGA cBioPortalOLR1
AceView (NCBI)OLR1
Genatlas (Paris)OLR1
SOURCE (Princeton)OLR1
Genetics Home Reference (NIH)OLR1
Genomic and cartography
GoldenPath hg38 (UCSC)OLR1  -     chr12:10158301-10172132 -  12p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OLR1  -     12p13.2   [Description]    (hg19-Feb_2009)
GoldenPathOLR1 - 12p13.2 [CytoView hg19]  OLR1 - 12p13.2 [CytoView hg38]
ImmunoBaseENSG00000173391
genome Data Viewer NCBIOLR1 [Mapview hg19]  
OMIM602601   608446   
Gene and transcription
Genbank (Entrez)AB010710 AB102861 AF035776 AK292124 AK295409
RefSeq transcript (Entrez)NM_001172632 NM_001172633 NM_002543
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OLR1
Alternative Splicing GalleryENSG00000173391
Gene ExpressionOLR1 [ NCBI-GEO ]   OLR1 [ EBI - ARRAY_EXPRESS ]   OLR1 [ SEEK ]   OLR1 [ MEM ]
Gene Expression Viewer (FireBrowse)OLR1 [ Firebrowse - Broad ]
GenevisibleExpression of OLR1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4973
GTEX Portal (Tissue expression)OLR1
Human Protein AtlasENSG00000173391-OLR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78380   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78380  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78380
Splice isoforms : SwissVarP78380
PhosPhoSitePlusP78380
Domaine pattern : Prosite (Expaxy)C_TYPE_LECTIN_2 (PS50041)   
Domains : Interpro (EBI)C-type_lectin-like    C-type_lectin-like/link_sf    CTDL_fold    Ly49_N    NKR-like_CTLD   
Domain families : Pfam (Sanger)Lectin_C (PF00059)    Ly49 (PF08391)   
Domain families : Pfam (NCBI)pfam00059    pfam08391   
Domain families : Smart (EMBL)CLECT (SM00034)  
Conserved Domain (NCBI)OLR1
Blocks (Seattle)OLR1
PDB (RSDB)1YPO    1YPQ    1YPU    1YXJ    1YXK    3VLG   
PDB Europe1YPO    1YPQ    1YPU    1YXJ    1YXK    3VLG   
PDB (PDBSum)1YPO    1YPQ    1YPU    1YXJ    1YXK    3VLG   
PDB (IMB)1YPO    1YPQ    1YPU    1YXJ    1YXK    3VLG   
Structural Biology KnowledgeBase1YPO    1YPQ    1YPU    1YXJ    1YXK    3VLG   
SCOP (Structural Classification of Proteins)1YPO    1YPQ    1YPU    1YXJ    1YXK    3VLG   
CATH (Classification of proteins structures)1YPO    1YPQ    1YPU    1YXJ    1YXK    3VLG   
SuperfamilyP78380
Human Protein Atlas [tissue]ENSG00000173391-OLR1 [tissue]
Peptide AtlasP78380
HPRD04003
IPIIPI00001759   IPI00909857   IPI01012871   IPI01014156   IPI00796311   IPI00910415   IPI01010867   IPI00941113   IPI01009459   IPI01015954   
Protein Interaction databases
DIP (DOE-UCLA)P78380
IntAct (EBI)P78380
BioGRIDOLR1
STRING (EMBL)OLR1
ZODIACOLR1
Ontologies - Pathways
QuickGOP78380
Ontology : AmiGOlow-density lipoprotein particle receptor activity  protein binding  extracellular region  nucleoplasm  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  proteolysis  endocytosis  inflammatory response  leukocyte cell-cell adhesion  blood circulation  cell death  membrane  carbohydrate binding  specific granule membrane  lipoprotein metabolic process  identical protein binding  intracellular membrane-bounded organelle  receptor complex  receptor complex  neutrophil degranulation  membrane raft  leukocyte migration  tertiary granule membrane  
Ontology : EGO-EBIlow-density lipoprotein particle receptor activity  protein binding  extracellular region  nucleoplasm  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  proteolysis  endocytosis  inflammatory response  leukocyte cell-cell adhesion  blood circulation  cell death  membrane  carbohydrate binding  specific granule membrane  lipoprotein metabolic process  identical protein binding  intracellular membrane-bounded organelle  receptor complex  receptor complex  neutrophil degranulation  membrane raft  leukocyte migration  tertiary granule membrane  
Pathways : KEGGPPAR signaling pathway    Phagosome   
NDEx NetworkOLR1
Atlas of Cancer Signalling NetworkOLR1
Wikipedia pathwaysOLR1
Orthology - Evolution
OrthoDB4973
GeneTree (enSembl)ENSG00000173391
Phylogenetic Trees/Animal Genes : TreeFamOLR1
HOGENOMP78380
Homologs : HomoloGeneOLR1
Homology/Alignments : Family Browser (UCSC)OLR1
Gene fusions - Rearrangements
Fusion : MitelmanXIAP/OLR1 [Xq25/12p13.2]  
Fusion : QuiverOLR1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOLR1 [hg38]
dbVarOLR1
ClinVarOLR1
MonarchOLR1
1000_GenomesOLR1 
Exome Variant ServerOLR1
GNOMAD BrowserENSG00000173391
Varsome BrowserOLR1
Genomic Variants (DGV)OLR1 [DGVbeta]
DECIPHEROLR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOLR1 
Mutations
ICGC Data PortalOLR1 
TCGA Data PortalOLR1 
Broad Tumor PortalOLR1
OASIS PortalOLR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOLR1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DOLR1
Mutations and Diseases : HGMDOLR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OLR1
DgiDB (Drug Gene Interaction Database)OLR1
DoCM (Curated mutations)OLR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OLR1 (select a term)
intoGenOLR1
Cancer3DOLR1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602601    608446   
Orphanet
DisGeNETOLR1
MedgenOLR1
Genetic Testing Registry OLR1
NextProtP78380 [Medical]
GENETestsOLR1
Target ValidationOLR1
Huge Navigator OLR1 [HugePedia]
ClinGenOLR1
Clinical trials, drugs, therapy
MyCancerGenomeOLR1
Protein Interactions : CTD
Pharm GKB GenePA31920
PharosP78380
Clinical trialOLR1
Miscellaneous
canSAR (ICR)OLR1 (select the gene name)
HarmonizomeOLR1
DataMed IndexOLR1
Probes
Litterature
PubMed289 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXOLR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:29:53 CET 2021
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