Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ONECUT1 (one cut homeobox 1)

Identity

Alias_namesHNF6
HNF6A
one cut domain
Alias_symbol (synonym)HNF-6
Other alias
HGNC (Hugo) ONECUT1
LocusID (NCBI) 3175
Atlas_Id 53307
Location 15q21.3  [Link to chromosome band 15q21]
Location_base_pair Starts at 52756963 and ends at 52790012 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCAR1 (10q21.3) / ONECUT1 (15q21.3)GPR141 (7p14.1) / ONECUT1 (15q21.3)ONECUT1 (15q21.3) / ITIH4 (3p21.1)
GPR141 7p14.1 / ONECUT1 15q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ONECUT1   8138
Cards
Entrez_Gene (NCBI)ONECUT1  3175  one cut homeobox 1
AliasesHNF-6; HNF6; HNF6A
GeneCards (Weizmann)ONECUT1
Ensembl hg19 (Hinxton)ENSG00000169856 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169856 [Gene_View]  chr15:52756963-52790012 [Contig_View]  ONECUT1 [Vega]
ICGC DataPortalENSG00000169856
TCGA cBioPortalONECUT1
AceView (NCBI)ONECUT1
Genatlas (Paris)ONECUT1
WikiGenes3175
SOURCE (Princeton)ONECUT1
Genetics Home Reference (NIH)ONECUT1
Genomic and cartography
GoldenPath hg38 (UCSC)ONECUT1  -     chr15:52756963-52790012 -  15q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ONECUT1  -     15q21.3   [Description]    (hg19-Feb_2009)
EnsemblONECUT1 - 15q21.3 [CytoView hg19]  ONECUT1 - 15q21.3 [CytoView hg38]
Mapping of homologs : NCBIONECUT1 [Mapview hg19]  ONECUT1 [Mapview hg38]
OMIM604164   
Gene and transcription
Genbank (Entrez)AA699732 BC140830 BP289459 BX118406 EU532019
RefSeq transcript (Entrez)NM_004498
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ONECUT1
Cluster EST : UnigeneHs.658573 [ NCBI ]
CGAP (NCI)Hs.658573
Alternative Splicing GalleryENSG00000169856
Gene ExpressionONECUT1 [ NCBI-GEO ]   ONECUT1 [ EBI - ARRAY_EXPRESS ]   ONECUT1 [ SEEK ]   ONECUT1 [ MEM ]
Gene Expression Viewer (FireBrowse)ONECUT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3175
GTEX Portal (Tissue expression)ONECUT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBC0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBC0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBC0
Splice isoforms : SwissVarQ9UBC0
PhosPhoSitePlusQ9UBC0
Domaine pattern : Prosite (Expaxy)CUT (PS51042)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)CUT_dom    Homeobox-like    Homeobox_dom    Lambda_DNA-bd_dom   
Domain families : Pfam (Sanger)CUT (PF02376)    Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam02376    pfam00046   
Domain families : Smart (EMBL)CUT (SM01109)  HOX (SM00389)  
Conserved Domain (NCBI)ONECUT1
DMDM Disease mutations3175
Blocks (Seattle)ONECUT1
SuperfamilyQ9UBC0
Human Protein AtlasENSG00000169856
Peptide AtlasQ9UBC0
HPRD05002
IPIIPI00002508   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBC0
IntAct (EBI)Q9UBC0
FunCoupENSG00000169856
BioGRIDONECUT1
STRING (EMBL)ONECUT1
ZODIACONECUT1
Ontologies - Pathways
QuickGOQ9UBC0
Ontology : AmiGOtranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  liver development  regulation of cell-matrix adhesion  epithelial cell development  DNA binding  nucleus  glucose metabolic process  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  Notch signaling pathway  endoderm development  anatomical structure morphogenesis  cell differentiation  B cell differentiation  positive regulation of cell migration  negative regulation of transforming growth factor beta receptor signaling pathway  endocrine pancreas development  cell fate commitment  positive regulation of transcription from RNA polymerase II promoter  spleen development  system development  cilium assembly  
Ontology : EGO-EBItranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  liver development  regulation of cell-matrix adhesion  epithelial cell development  DNA binding  nucleus  glucose metabolic process  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  Notch signaling pathway  endoderm development  anatomical structure morphogenesis  cell differentiation  B cell differentiation  positive regulation of cell migration  negative regulation of transforming growth factor beta receptor signaling pathway  endocrine pancreas development  cell fate commitment  positive regulation of transcription from RNA polymerase II promoter  spleen development  system development  cilium assembly  
Pathways : KEGGMaturity onset diabetes of the young   
NDEx NetworkONECUT1
Atlas of Cancer Signalling NetworkONECUT1
Wikipedia pathwaysONECUT1
Orthology - Evolution
OrthoDB3175
GeneTree (enSembl)ENSG00000169856
Phylogenetic Trees/Animal Genes : TreeFamONECUT1
HOVERGENQ9UBC0
HOGENOMQ9UBC0
Homologs : HomoloGeneONECUT1
Homology/Alignments : Family Browser (UCSC)ONECUT1
Gene fusions - Rearrangements
Fusion : MitelmanGPR141/ONECUT1 [7p14.1/15q21.3]  [t(7;15)(p14;q21)]  
Fusion: TCGAGPR141 7p14.1 ONECUT1 15q21.3 LAML
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerONECUT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ONECUT1
dbVarONECUT1
ClinVarONECUT1
1000_GenomesONECUT1 
Exome Variant ServerONECUT1
ExAC (Exome Aggregation Consortium)ONECUT1 (select the gene name)
Genetic variants : HAPMAP3175
Genomic Variants (DGV)ONECUT1 [DGVbeta]
DECIPHERONECUT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisONECUT1 
Mutations
ICGC Data PortalONECUT1 
TCGA Data PortalONECUT1 
Broad Tumor PortalONECUT1
OASIS PortalONECUT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICONECUT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDONECUT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ONECUT1
DgiDB (Drug Gene Interaction Database)ONECUT1
DoCM (Curated mutations)ONECUT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ONECUT1 (select a term)
intoGenONECUT1
Cancer3DONECUT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604164   
Orphanet
MedgenONECUT1
Genetic Testing Registry ONECUT1
NextProtQ9UBC0 [Medical]
TSGene3175
GENETestsONECUT1
Huge Navigator ONECUT1 [HugePedia]
snp3D : Map Gene to Disease3175
BioCentury BCIQONECUT1
ClinGenONECUT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3175
Chemical/Pharm GKB GenePA31924
Clinical trialONECUT1
Miscellaneous
canSAR (ICR)ONECUT1 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineONECUT1
EVEXONECUT1
GoPubMedONECUT1
iHOPONECUT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:29:41 CEST 2017

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