Atlas of Genetics and Cytogenetics in Oncology and Haematology


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OPLAH (5-oxoprolinase (ATP-hydrolysing))

Identity

Alias_symbol (synonym)OPLA
5-Opase
Other aliasOPLAHD
HGNC (Hugo) OPLAH
LocusID (NCBI) 26873
Atlas_Id 71129
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 144051266 and ends at 144060703 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OPLAH   8149
Cards
Entrez_Gene (NCBI)OPLAH  26873  5-oxoprolinase (ATP-hydrolysing)
Aliases5-Opase; OPLA; OPLAHD
GeneCards (Weizmann)OPLAH
Ensembl hg19 (Hinxton)ENSG00000178814 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178814 [Gene_View]  chr8:144051266-144060703 [Contig_View]  OPLAH [Vega]
ICGC DataPortalENSG00000178814
TCGA cBioPortalOPLAH
AceView (NCBI)OPLAH
Genatlas (Paris)OPLAH
WikiGenes26873
SOURCE (Princeton)OPLAH
Genetics Home Reference (NIH)OPLAH
Genomic and cartography
GoldenPath hg38 (UCSC)OPLAH  -     chr8:144051266-144060703 -  8q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OPLAH  -     8q24.3   [Description]    (hg19-Feb_2009)
EnsemblOPLAH - 8q24.3 [CytoView hg19]  OPLAH - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBIOPLAH [Mapview hg19]  OPLAH [Mapview hg38]
OMIM260005   614243   
Gene and transcription
Genbank (Entrez)AB122018 AF217994 AL096750 BC036944 BC041576
RefSeq transcript (Entrez)NM_017570
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OPLAH
Cluster EST : UnigeneHs.305882 [ NCBI ]
CGAP (NCI)Hs.305882
Alternative Splicing GalleryENSG00000178814
Gene ExpressionOPLAH [ NCBI-GEO ]   OPLAH [ EBI - ARRAY_EXPRESS ]   OPLAH [ SEEK ]   OPLAH [ MEM ]
Gene Expression Viewer (FireBrowse)OPLAH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26873
GTEX Portal (Tissue expression)OPLAH
Human Protein AtlasENSG00000178814-OPLAH [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14841   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14841  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14841
Splice isoforms : SwissVarO14841
Catalytic activity : Enzyme3.5.2.9 [ Enzyme-Expasy ]   3.5.2.93.5.2.9 [ IntEnz-EBI ]   3.5.2.9 [ BRENDA ]   3.5.2.9 [ KEGG ]   
PhosPhoSitePlusO14841
Domains : Interpro (EBI)Hydant_A_N    Hydantoinase_A    Hydantoinase_B   
Domain families : Pfam (Sanger)Hydant_A_N (PF05378)    Hydantoinase_A (PF01968)    Hydantoinase_B (PF02538)   
Domain families : Pfam (NCBI)pfam05378    pfam01968    pfam02538   
Conserved Domain (NCBI)OPLAH
DMDM Disease mutations26873
Blocks (Seattle)OPLAH
SuperfamilyO14841
Human Protein Atlas [tissue]ENSG00000178814-OPLAH [tissue]
Peptide AtlasO14841
HPRD14880
IPIIPI00418382   IPI00030020   
Protein Interaction databases
DIP (DOE-UCLA)O14841
IntAct (EBI)O14841
FunCoupENSG00000178814
BioGRIDOPLAH
STRING (EMBL)OPLAH
ZODIACOPLAH
Ontologies - Pathways
QuickGOO14841
Ontology : AmiGOATP binding  cytosol  glutathione biosynthetic process  5-oxoprolinase (ATP-hydrolyzing) activity  
Ontology : EGO-EBIATP binding  cytosol  glutathione biosynthetic process  5-oxoprolinase (ATP-hydrolyzing) activity  
Pathways : KEGGGlutathione metabolism   
NDEx NetworkOPLAH
Atlas of Cancer Signalling NetworkOPLAH
Wikipedia pathwaysOPLAH
Orthology - Evolution
OrthoDB26873
GeneTree (enSembl)ENSG00000178814
Phylogenetic Trees/Animal Genes : TreeFamOPLAH
HOVERGENO14841
HOGENOMO14841
Homologs : HomoloGeneOPLAH
Homology/Alignments : Family Browser (UCSC)OPLAH
Gene fusions - Rearrangements
Tumor Fusion PortalOPLAH
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOPLAH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OPLAH
dbVarOPLAH
ClinVarOPLAH
1000_GenomesOPLAH 
Exome Variant ServerOPLAH
ExAC (Exome Aggregation Consortium)ENSG00000178814
GNOMAD BrowserENSG00000178814
Genetic variants : HAPMAP26873
Genomic Variants (DGV)OPLAH [DGVbeta]
DECIPHEROPLAH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOPLAH 
Mutations
ICGC Data PortalOPLAH 
TCGA Data PortalOPLAH 
Broad Tumor PortalOPLAH
OASIS PortalOPLAH [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDOPLAH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OPLAH
DgiDB (Drug Gene Interaction Database)OPLAH
DoCM (Curated mutations)OPLAH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OPLAH (select a term)
intoGenOPLAH
Cancer3DOPLAH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM260005    614243   
Orphanet10327   
DisGeNETOPLAH
MedgenOPLAH
Genetic Testing Registry OPLAH
NextProtO14841 [Medical]
TSGene26873
GENETestsOPLAH
Target ValidationOPLAH
Huge Navigator OPLAH [HugePedia]
snp3D : Map Gene to Disease26873
BioCentury BCIQOPLAH
ClinGenOPLAH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26873
Chemical/Pharm GKB GenePA31935
Clinical trialOPLAH
Miscellaneous
canSAR (ICR)OPLAH (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOPLAH
EVEXOPLAH
GoPubMedOPLAH
iHOPOPLAH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:18:47 CET 2017

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