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OPN4 (opsin 4)

Identity

Alias (NCBI)MOP
HGNC (Hugo) OPN4
HGNC Alias symbMOP
melanopsin
HGNC Alias namemelanopsin
HGNC Previous nameopsin 4 (melanopsin)
LocusID (NCBI) 94233
Atlas_Id 71135
Location 10q23.2  [Link to chromosome band 10q23]
Location_base_pair Starts at 86654547 and ends at 86666459 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)OPN4   14449
Cards
Entrez_Gene (NCBI)OPN4    opsin 4
AliasesMOP
GeneCards (Weizmann)OPN4
Ensembl hg19 (Hinxton)ENSG00000122375 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122375 [Gene_View]  ENSG00000122375 [Sequence]  chr10:86654547-86666459 [Contig_View]  OPN4 [Vega]
ICGC DataPortalENSG00000122375
TCGA cBioPortalOPN4
AceView (NCBI)OPN4
Genatlas (Paris)OPN4
SOURCE (Princeton)OPN4
Genetics Home Reference (NIH)OPN4
Genomic and cartography
GoldenPath hg38 (UCSC)OPN4  -     chr10:86654547-86666459 +  10q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OPN4  -     10q23.2   [Description]    (hg19-Feb_2009)
GoldenPathOPN4 - 10q23.2 [CytoView hg19]  OPN4 - 10q23.2 [CytoView hg38]
ImmunoBaseENSG00000122375
Genome Data Viewer NCBIOPN4 [Mapview hg19]  
OMIM606665   
Gene and transcription
Genbank (Entrez)AK310520 BC029291 BC113558 BC143688 BM672338
RefSeq transcript (Entrez)NM_001030015 NM_033282
Consensus coding sequences : CCDS (NCBI)OPN4
Gene ExpressionOPN4 [ NCBI-GEO ]   OPN4 [ EBI - ARRAY_EXPRESS ]   OPN4 [ SEEK ]   OPN4 [ MEM ]
Gene Expression Viewer (FireBrowse)OPN4 [ Firebrowse - Broad ]
GenevisibleExpression of OPN4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)94233
GTEX Portal (Tissue expression)OPN4
Human Protein AtlasENSG00000122375-OPN4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHM6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHM6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHM6
PhosPhoSitePlusQ9UHM6
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)    OPSIN (PS00238)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Opsin    Retinal_BS   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)OPN4
SuperfamilyQ9UHM6
AlphaFold pdb e-kbQ9UHM6   
Human Protein Atlas [tissue]ENSG00000122375-OPN4 [tissue]
HPRD05977
Protein Interaction databases
DIP (DOE-UCLA)Q9UHM6
IntAct (EBI)Q9UHM6
BioGRIDOPN4
STRING (EMBL)OPN4
ZODIACOPN4
Ontologies - Pathways
QuickGOQ9UHM6
Ontology : AmiGO11-cis retinal binding  protein binding  plasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  visual perception  phototransduction  phototransduction  optokinetic behavior  G protein-coupled photoreceptor activity  G protein-coupled photoreceptor activity  detection of visible light  integral component of membrane  protein-chromophore linkage  axon  dendrite  regulation of circadian rhythm  thermotaxis  perikaryon  rhythmic process  detection of temperature stimulus involved in thermoception  cellular response to light stimulus  photoreceptor disc membrane  hyaloid vascular plexus regression  sperm head plasma membrane  
Ontology : EGO-EBI11-cis retinal binding  protein binding  plasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  visual perception  phototransduction  phototransduction  optokinetic behavior  G protein-coupled photoreceptor activity  G protein-coupled photoreceptor activity  detection of visible light  integral component of membrane  protein-chromophore linkage  axon  dendrite  regulation of circadian rhythm  thermotaxis  perikaryon  rhythmic process  detection of temperature stimulus involved in thermoception  cellular response to light stimulus  photoreceptor disc membrane  hyaloid vascular plexus regression  sperm head plasma membrane  
NDEx NetworkOPN4
Atlas of Cancer Signalling NetworkOPN4
Wikipedia pathwaysOPN4
Orthology - Evolution
OrthoDB94233
GeneTree (enSembl)ENSG00000122375
Phylogenetic Trees/Animal Genes : TreeFamOPN4
Homologs : HomoloGeneOPN4
Homology/Alignments : Family Browser (UCSC)OPN4
Gene fusions - Rearrangements
Fusion : QuiverOPN4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOPN4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OPN4
dbVarOPN4
ClinVarOPN4
MonarchOPN4
1000_GenomesOPN4 
Exome Variant ServerOPN4
GNOMAD BrowserENSG00000122375
Varsome BrowserOPN4
ACMGOPN4 variants
VarityQ9UHM6
Genomic Variants (DGV)OPN4 [DGVbeta]
DECIPHEROPN4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOPN4 
Mutations
ICGC Data PortalOPN4 
TCGA Data PortalOPN4 
Broad Tumor PortalOPN4
OASIS PortalOPN4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOPN4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DOPN4
Mutations and Diseases : HGMDOPN4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaOPN4
DgiDB (Drug Gene Interaction Database)OPN4
DoCM (Curated mutations)OPN4
CIViC (Clinical Interpretations of Variants in Cancer)OPN4
Cancer3DOPN4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606665   
Orphanet
DisGeNETOPN4
MedgenOPN4
Genetic Testing Registry OPN4
NextProtQ9UHM6 [Medical]
GENETestsOPN4
Target ValidationOPN4
Huge Navigator OPN4 [HugePedia]
ClinGenOPN4
Clinical trials, drugs, therapy
MyCancerGenomeOPN4
Protein Interactions : CTDOPN4
Pharm GKB GenePA31940
PharosQ9UHM6
Clinical trialOPN4
Miscellaneous
canSAR (ICR)OPN4
HarmonizomeOPN4
DataMed IndexOPN4
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXOPN4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:13:38 CEST 2021

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