Atlas of Genetics and Cytogenetics in Oncology and Haematology


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OPRK1 (opioid receptor kappa 1)

Identity

Alias_namesopioid receptor
Alias_symbol (synonym)KOR
OPRK
Other aliasK-OR-1
KOR-1
HGNC (Hugo) OPRK1
LocusID (NCBI) 4986
Atlas_Id 49809
Location 8q11.23  [Link to chromosome band 8q11]
Location_base_pair Starts at 53225716 and ends at 53251697 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OPRK1   8154
Cards
Entrez_Gene (NCBI)OPRK1  4986  opioid receptor kappa 1
AliasesK-OR-1; KOR; KOR-1; OPRK
GeneCards (Weizmann)OPRK1
Ensembl hg19 (Hinxton)ENSG00000082556 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000082556 [Gene_View]  chr8:53225716-53251697 [Contig_View]  OPRK1 [Vega]
ICGC DataPortalENSG00000082556
TCGA cBioPortalOPRK1
AceView (NCBI)OPRK1
Genatlas (Paris)OPRK1
WikiGenes4986
SOURCE (Princeton)OPRK1
Genetics Home Reference (NIH)OPRK1
Genomic and cartography
GoldenPath hg38 (UCSC)OPRK1  -     chr8:53225716-53251697 -  8q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OPRK1  -     8q11.23   [Description]    (hg19-Feb_2009)
EnsemblOPRK1 - 8q11.23 [CytoView hg19]  OPRK1 - 8q11.23 [CytoView hg38]
Mapping of homologs : NCBIOPRK1 [Mapview hg19]  OPRK1 [Mapview hg38]
OMIM165196   
Gene and transcription
Genbank (Entrez)AF498922 AK023198 AK310233 AK310407 AK313058
RefSeq transcript (Entrez)NM_000912 NM_001282904 NM_001318497
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OPRK1
Cluster EST : UnigeneHs.106795 [ NCBI ]
CGAP (NCI)Hs.106795
Alternative Splicing GalleryENSG00000082556
Gene ExpressionOPRK1 [ NCBI-GEO ]   OPRK1 [ EBI - ARRAY_EXPRESS ]   OPRK1 [ SEEK ]   OPRK1 [ MEM ]
Gene Expression Viewer (FireBrowse)OPRK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4986
GTEX Portal (Tissue expression)OPRK1
Human Protein AtlasENSG00000082556-OPRK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41145   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41145  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41145
Splice isoforms : SwissVarP41145
PhosPhoSitePlusP41145
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Kappa_opi_rcpt    Opioid_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)OPRK1
DMDM Disease mutations4986
Blocks (Seattle)OPRK1
PDB (SRS)2A0D    2IQN    4DJH   
PDB (PDBSum)2A0D    2IQN    4DJH   
PDB (IMB)2A0D    2IQN    4DJH   
PDB (RSDB)2A0D    2IQN    4DJH   
Structural Biology KnowledgeBase2A0D    2IQN    4DJH   
SCOP (Structural Classification of Proteins)2A0D    2IQN    4DJH   
CATH (Classification of proteins structures)2A0D    2IQN    4DJH   
SuperfamilyP41145
Human Protein Atlas [tissue]ENSG00000082556-OPRK1 [tissue]
Peptide AtlasP41145
HPRD01309
IPIIPI00012735   IPI00789992   IPI00974279   
Protein Interaction databases
DIP (DOE-UCLA)P41145
IntAct (EBI)P41145
FunCoupENSG00000082556
BioGRIDOPRK1
STRING (EMBL)OPRK1
ZODIACOPRK1
Ontologies - Pathways
QuickGOP41145
Ontology : AmiGOopioid receptor activity  protein binding  plasma membrane  integral component of plasma membrane  immune response  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  neuropeptide signaling pathway  chemical synaptic transmission  sensory perception  behavior  locomotory behavior  response to radiation  integral component of membrane  sensory perception of pain  sensory perception of pain  dendrite  adenylate cyclase-inhibiting opioid receptor signaling pathway  response to insulin  positive regulation of dopamine secretion  negative regulation of luteinizing hormone secretion  opioid receptor signaling pathway  dynorphin receptor activity  dynorphin receptor activity  positive regulation of locomotion  maternal behavior  eating behavior  neuropeptide binding  neuron projection  perikaryon  response to morphine  response to estrogen  axon terminus  estrous cycle  response to ethanol  regulation of saliva secretion  behavioral response to cocaine  sensory perception of temperature stimulus  defense response to virus  regulation of sensory perception of pain  cellular response to lipopolysaccharide  positive regulation of p38MAPK cascade  positive regulation of potassium ion transmembrane transport  regulation of aerobic respiration  response to acrylamide  conditioned place preference  regulation of energy homeostasis  
Ontology : EGO-EBIopioid receptor activity  protein binding  plasma membrane  integral component of plasma membrane  immune response  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  neuropeptide signaling pathway  chemical synaptic transmission  sensory perception  behavior  locomotory behavior  response to radiation  integral component of membrane  sensory perception of pain  sensory perception of pain  dendrite  adenylate cyclase-inhibiting opioid receptor signaling pathway  response to insulin  positive regulation of dopamine secretion  negative regulation of luteinizing hormone secretion  opioid receptor signaling pathway  dynorphin receptor activity  dynorphin receptor activity  positive regulation of locomotion  maternal behavior  eating behavior  neuropeptide binding  neuron projection  perikaryon  response to morphine  response to estrogen  axon terminus  estrous cycle  response to ethanol  regulation of saliva secretion  behavioral response to cocaine  sensory perception of temperature stimulus  defense response to virus  regulation of sensory perception of pain  cellular response to lipopolysaccharide  positive regulation of p38MAPK cascade  positive regulation of potassium ion transmembrane transport  regulation of aerobic respiration  response to acrylamide  conditioned place preference  regulation of energy homeostasis  
Pathways : BIOCARTARepression of Pain Sensation by the Transcriptional Regulator DREAM [Genes]   
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkOPRK1
Atlas of Cancer Signalling NetworkOPRK1
Wikipedia pathwaysOPRK1
Orthology - Evolution
OrthoDB4986
GeneTree (enSembl)ENSG00000082556
Phylogenetic Trees/Animal Genes : TreeFamOPRK1
HOVERGENP41145
HOGENOMP41145
Homologs : HomoloGeneOPRK1
Homology/Alignments : Family Browser (UCSC)OPRK1
Gene fusions - Rearrangements
Tumor Fusion PortalOPRK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOPRK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OPRK1
dbVarOPRK1
ClinVarOPRK1
1000_GenomesOPRK1 
Exome Variant ServerOPRK1
ExAC (Exome Aggregation Consortium)ENSG00000082556
GNOMAD BrowserENSG00000082556
Genetic variants : HAPMAP4986
Genomic Variants (DGV)OPRK1 [DGVbeta]
DECIPHEROPRK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOPRK1 
Mutations
ICGC Data PortalOPRK1 
TCGA Data PortalOPRK1 
Broad Tumor PortalOPRK1
OASIS PortalOPRK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOPRK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOPRK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OPRK1
DgiDB (Drug Gene Interaction Database)OPRK1
DoCM (Curated mutations)OPRK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OPRK1 (select a term)
intoGenOPRK1
Cancer3DOPRK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM165196   
Orphanet
DisGeNETOPRK1
MedgenOPRK1
Genetic Testing Registry OPRK1
NextProtP41145 [Medical]
TSGene4986
GENETestsOPRK1
Target ValidationOPRK1
Huge Navigator OPRK1 [HugePedia]
snp3D : Map Gene to Disease4986
BioCentury BCIQOPRK1
ClinGenOPRK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4986
Chemical/Pharm GKB GenePA31943
Clinical trialOPRK1
Miscellaneous
canSAR (ICR)OPRK1 (select the gene name)
Probes
Litterature
PubMed97 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOPRK1
EVEXOPRK1
GoPubMedOPRK1
iHOPOPRK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:27:16 CET 2017

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