OPRL1 (opioid related nociceptin receptor 1)

2014-11-01  

Identity

HGNC
LOCATION
20q13.33
LOCUSID
ALIAS
KOR-3,KOR3,NOCIR,NOP,NOPr,OOR,OPRL,ORL1,PNOCR
FUSION GENES

Other Information

Locus ID:

NCBI: 4987
MIM: 602548
HGNC: 8155
Ensembl: ENSG00000125510

Variants:

dbSNP: 4987
ClinVar: 4987
TCGA: ENSG00000125510
COSMIC: OPRL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125510ENST00000336866P41146
ENSG00000125510ENST00000349451P41146
ENSG00000125510ENST00000355631P41146

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445043Opioid-Related DisordersDiseaseClinicalAnnotation, VariantAnnotationassociatedPD
PA452618opioidsChemicalClinicalAnnotation, VariantAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
225961632012Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.155
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
237408992013Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD.50
237990312013Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls.24
150167232004Ligand-regulated internalization of the opioid receptor-like 1: a confocal study.19
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
206827552011A pilot study of gene/gene and gene/environment interactions in Alzheimer disease.19
179107402008Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence.16
179107402008Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence.16
182693822008Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence.13

Citation

Dessen P

OPRL1 (opioid related nociceptin receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71137/oprl1