Atlas of Genetics and Cytogenetics in Oncology and Haematology


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OPRL1 (opioid related nociceptin receptor 1)

Identity

Alias_namesopiate receptor-like 1
Alias_symbol (synonym)NOCIR
ORL1
OOR
KOR-3
NOPr
Other aliasNOP
HGNC (Hugo) OPRL1
LocusID (NCBI) 4987
Atlas_Id 71137
Location 20q13.33  [Link to chromosome band 20q13]
Location_base_pair Starts at 64080082 and ends at 64100643 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
OPRL1 (20q13.33) / PRPF6 (20q13.33)OPRL1 (20q13.33) / RUSC1 (1q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OPRL1   8155
Cards
Entrez_Gene (NCBI)OPRL1  4987  opioid related nociceptin receptor 1
AliasesKOR-3; NOCIR; NOP; NOPr; 
OOR; ORL1
GeneCards (Weizmann)OPRL1
Ensembl hg19 (Hinxton)ENSG00000125510 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125510 [Gene_View]  chr20:64080082-64100643 [Contig_View]  OPRL1 [Vega]
ICGC DataPortalENSG00000125510
TCGA cBioPortalOPRL1
AceView (NCBI)OPRL1
Genatlas (Paris)OPRL1
WikiGenes4987
SOURCE (Princeton)OPRL1
Genetics Home Reference (NIH)OPRL1
Genomic and cartography
GoldenPath hg38 (UCSC)OPRL1  -     chr20:64080082-64100643 +  20q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OPRL1  -     20q13.33   [Description]    (hg19-Feb_2009)
EnsemblOPRL1 - 20q13.33 [CytoView hg19]  OPRL1 - 20q13.33 [CytoView hg38]
Mapping of homologs : NCBIOPRL1 [Mapview hg19]  OPRL1 [Mapview hg38]
OMIM602548   
Gene and transcription
Genbank (Entrez)AF115266 AF126470 AF285093 AF285094 AF285095
RefSeq transcript (Entrez)NM_000913 NM_001200019 NM_001318853 NM_001318854 NM_001318855 NM_182647
RefSeq genomic (Entrez)NC_000020 NC_018931 NT_187624
Consensus coding sequences : CCDS (NCBI)OPRL1
Cluster EST : UnigeneHs.736944 [ NCBI ]
CGAP (NCI)Hs.736944
Alternative Splicing GalleryENSG00000125510
Gene ExpressionOPRL1 [ NCBI-GEO ]   OPRL1 [ EBI - ARRAY_EXPRESS ]   OPRL1 [ SEEK ]   OPRL1 [ MEM ]
Gene Expression Viewer (FireBrowse)OPRL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4987
GTEX Portal (Tissue expression)OPRL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41146   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41146  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41146
Splice isoforms : SwissVarP41146
PhosPhoSitePlusP41146
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Opioid_rcpt    X_opioid_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)OPRL1
DMDM Disease mutations4987
Blocks (Seattle)OPRL1
PDB (SRS)4EA3    5DHG    5DHH   
PDB (PDBSum)4EA3    5DHG    5DHH   
PDB (IMB)4EA3    5DHG    5DHH   
PDB (RSDB)4EA3    5DHG    5DHH   
Structural Biology KnowledgeBase4EA3    5DHG    5DHH   
SCOP (Structural Classification of Proteins)4EA3    5DHG    5DHH   
CATH (Classification of proteins structures)4EA3    5DHG    5DHH   
SuperfamilyP41146
Human Protein AtlasENSG00000125510
Peptide AtlasP41146
HPRD03971
IPIIPI00012736   IPI00215696   IPI00383507   
Protein Interaction databases
DIP (DOE-UCLA)P41146
IntAct (EBI)P41146
FunCoupENSG00000125510
BioGRIDOPRL1
STRING (EMBL)OPRL1
ZODIACOPRL1
Ontologies - Pathways
QuickGOP41146
Ontology : AmiGOnociceptin receptor activity  positive regulation of protein phosphorylation  G-protein coupled receptor activity  G-protein coupled receptor activity  protein binding  plasma membrane  integral component of plasma membrane  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  neuropeptide signaling pathway  chemical synaptic transmission  sensory perception  protein C-terminus binding  sensory perception of pain  sensory perception of pain  negative regulation of cAMP biosynthetic process  cytoplasmic vesicle  response to estradiol  positive regulation of urine volume  opioid receptor signaling pathway  eating behavior  neuropeptide binding  neuron projection  estrous cycle  negative regulation of blood pressure  positive regulation of gastric acid secretion  negative regulation of voltage-gated calcium channel activity  positive regulation of sensory perception of pain  regulation of locomotor rhythm  
Ontology : EGO-EBInociceptin receptor activity  positive regulation of protein phosphorylation  G-protein coupled receptor activity  G-protein coupled receptor activity  protein binding  plasma membrane  integral component of plasma membrane  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  neuropeptide signaling pathway  chemical synaptic transmission  sensory perception  protein C-terminus binding  sensory perception of pain  sensory perception of pain  negative regulation of cAMP biosynthetic process  cytoplasmic vesicle  response to estradiol  positive regulation of urine volume  opioid receptor signaling pathway  eating behavior  neuropeptide binding  neuron projection  estrous cycle  negative regulation of blood pressure  positive regulation of gastric acid secretion  negative regulation of voltage-gated calcium channel activity  positive regulation of sensory perception of pain  regulation of locomotor rhythm  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkOPRL1
Atlas of Cancer Signalling NetworkOPRL1
Wikipedia pathwaysOPRL1
Orthology - Evolution
OrthoDB4987
GeneTree (enSembl)ENSG00000125510
Phylogenetic Trees/Animal Genes : TreeFamOPRL1
HOVERGENP41146
HOGENOMP41146
Homologs : HomoloGeneOPRL1
Homology/Alignments : Family Browser (UCSC)OPRL1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOPRL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OPRL1
dbVarOPRL1
ClinVarOPRL1
1000_GenomesOPRL1 
Exome Variant ServerOPRL1
ExAC (Exome Aggregation Consortium)OPRL1 (select the gene name)
Genetic variants : HAPMAP4987
Genomic Variants (DGV)OPRL1 [DGVbeta]
DECIPHEROPRL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOPRL1 
Mutations
ICGC Data PortalOPRL1 
TCGA Data PortalOPRL1 
Broad Tumor PortalOPRL1
OASIS PortalOPRL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOPRL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOPRL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OPRL1
DgiDB (Drug Gene Interaction Database)OPRL1
DoCM (Curated mutations)OPRL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OPRL1 (select a term)
intoGenOPRL1
Cancer3DOPRL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602548   
Orphanet
MedgenOPRL1
Genetic Testing Registry OPRL1
NextProtP41146 [Medical]
TSGene4987
GENETestsOPRL1
Target ValidationOPRL1
Huge Navigator OPRL1 [HugePedia]
snp3D : Map Gene to Disease4987
BioCentury BCIQOPRL1
ClinGenOPRL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4987
Chemical/Pharm GKB GenePA31944
Clinical trialOPRL1
Miscellaneous
canSAR (ICR)OPRL1 (select the gene name)
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOPRL1
EVEXOPRL1
GoPubMedOPRL1
iHOPOPRL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:33:38 CEST 2017

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