Atlas of Genetics and Cytogenetics in Oncology and Haematology


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OPRM1 (opioid receptor mu 1)

Identity

Alias_namesopioid receptor
Alias_symbol (synonym)MOR1
Other aliasLMOR
M-OR-1
MOP
MOR
OPRM
HGNC (Hugo) OPRM1
LocusID (NCBI) 4988
Atlas_Id 50098
Location 6q25.2  [Link to chromosome band 6q25]
Location_base_pair Starts at 154089762 and ends at 154091957 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OPRM1   8156
LRG (Locus Reference Genomic)LRG_1007
Cards
Entrez_Gene (NCBI)OPRM1  4988  opioid receptor mu 1
AliasesLMOR; M-OR-1; MOP; MOR; 
MOR1; OPRM
GeneCards (Weizmann)OPRM1
Ensembl hg19 (Hinxton)ENSG00000112038 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112038 [Gene_View]  ENSG00000112038 [Sequence]  chr6:154089762-154091957 [Contig_View]  OPRM1 [Vega]
ICGC DataPortalENSG00000112038
TCGA cBioPortalOPRM1
AceView (NCBI)OPRM1
Genatlas (Paris)OPRM1
WikiGenes4988
SOURCE (Princeton)OPRM1
Genetics Home Reference (NIH)OPRM1
Genomic and cartography
GoldenPath hg38 (UCSC)OPRM1  -     chr6:154089762-154091957 +  6q25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OPRM1  -     6q25.2   [Description]    (hg19-Feb_2009)
EnsemblOPRM1 - 6q25.2 [CytoView hg19]  OPRM1 - 6q25.2 [CytoView hg38]
Mapping of homologs : NCBIOPRM1 [Mapview hg19]  OPRM1 [Mapview hg38]
OMIM600018   
Gene and transcription
Genbank (Entrez)AK309655 AK313901 AY036622 AY036623 AY195733
RefSeq transcript (Entrez)NM_000914 NM_001008503 NM_001008504 NM_001008505 NM_001145279 NM_001145280 NM_001145281 NM_001145282 NM_001145283 NM_001145284 NM_001145285 NM_001145286 NM_001145287 NM_001285522 NM_001285523 NM_001285524 NM_001285526 NM_001285527 NM_001285528
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OPRM1
Cluster EST : UnigeneHs.2353 [ NCBI ]
CGAP (NCI)Hs.2353
Alternative Splicing GalleryENSG00000112038
Gene ExpressionOPRM1 [ NCBI-GEO ]   OPRM1 [ EBI - ARRAY_EXPRESS ]   OPRM1 [ SEEK ]   OPRM1 [ MEM ]
Gene Expression Viewer (FireBrowse)OPRM1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4988
GTEX Portal (Tissue expression)OPRM1
Human Protein AtlasENSG00000112038-OPRM1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35372   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35372  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35372
Splice isoforms : SwissVarP35372
PhosPhoSitePlusP35372
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Mu_opioid_rcpt    Opioid_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)OPRM1
DMDM Disease mutations4988
Blocks (Seattle)OPRM1
SuperfamilyP35372
Human Protein Atlas [tissue]ENSG00000112038-OPRM1 [tissue]
Peptide AtlasP35372
HPRD02484
IPIIPI00514084   IPI00922644   IPI00975883   IPI00967650   IPI00217416   IPI00922515   IPI00942295   IPI00943201   IPI00922493   IPI00922551   IPI00922913   IPI00930737   IPI00976694   IPI00922430   IPI00922177   IPI00977804   
Protein Interaction databases
DIP (DOE-UCLA)P35372
IntAct (EBI)P35372
FunCoupENSG00000112038
BioGRIDOPRM1
STRING (EMBL)OPRM1
ZODIACOPRM1
Ontologies - Pathways
QuickGOP35372
Ontology : AmiGOG-protein alpha-subunit binding  G-protein alpha-subunit binding  acute inflammatory response to antigenic stimulus  G protein-coupled receptor activity  G protein-coupled receptor activity  beta-endorphin receptor activity  beta-endorphin receptor activity  voltage-gated calcium channel activity  protein binding  endosome  endoplasmic reticulum  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  focal adhesion  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-activating dopamine receptor signaling pathway  negative regulation of adenylate cyclase activity  phospholipase C-activating G protein-coupled receptor signaling pathway  neuropeptide signaling pathway  sensory perception  locomotory behavior  protein C-terminus binding  negative regulation of cell proliferation  response to radiation  cytokine-mediated signaling pathway  sensory perception of pain  sensory perception of pain  protein domain specific binding  axon  dendrite  filamin binding  adenylate cyclase-inhibiting opioid receptor signaling pathway  G-protein beta-subunit binding  response to food  positive regulation of appetite  response to lipopolysaccharide  dendrite membrane  dendrite cytoplasm  opioid receptor signaling pathway  opioid receptor signaling pathway  morphine receptor activity  morphine receptor activity  wound healing  response to cocaine  sarcolemma  eating behavior  neuropeptide binding  perikaryon  estrous cycle  membrane raft  behavioral response to ethanol  positive regulation of neurogenesis  regulation of sensory perception of pain  excitatory postsynaptic potential  negative regulation of Wnt protein secretion  positive regulation of ERK1 and ERK2 cascade  calcium ion transmembrane transport  response to growth factor  cellular response to morphine  regulation of cellular response to stress  spine apparatus  integral component of postsynaptic membrane  integral component of presynaptic membrane  negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  regulation of NMDA receptor activity  
Ontology : EGO-EBIG-protein alpha-subunit binding  G-protein alpha-subunit binding  acute inflammatory response to antigenic stimulus  G protein-coupled receptor activity  G protein-coupled receptor activity  beta-endorphin receptor activity  beta-endorphin receptor activity  voltage-gated calcium channel activity  protein binding  endosome  endoplasmic reticulum  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  focal adhesion  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-activating dopamine receptor signaling pathway  negative regulation of adenylate cyclase activity  phospholipase C-activating G protein-coupled receptor signaling pathway  neuropeptide signaling pathway  sensory perception  locomotory behavior  protein C-terminus binding  negative regulation of cell proliferation  response to radiation  cytokine-mediated signaling pathway  sensory perception of pain  sensory perception of pain  protein domain specific binding  axon  dendrite  filamin binding  adenylate cyclase-inhibiting opioid receptor signaling pathway  G-protein beta-subunit binding  response to food  positive regulation of appetite  response to lipopolysaccharide  dendrite membrane  dendrite cytoplasm  opioid receptor signaling pathway  opioid receptor signaling pathway  morphine receptor activity  morphine receptor activity  wound healing  response to cocaine  sarcolemma  eating behavior  neuropeptide binding  perikaryon  estrous cycle  membrane raft  behavioral response to ethanol  positive regulation of neurogenesis  regulation of sensory perception of pain  excitatory postsynaptic potential  negative regulation of Wnt protein secretion  positive regulation of ERK1 and ERK2 cascade  calcium ion transmembrane transport  response to growth factor  cellular response to morphine  regulation of cellular response to stress  spine apparatus  integral component of postsynaptic membrane  integral component of presynaptic membrane  negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  regulation of NMDA receptor activity  
Pathways : KEGGNeuroactive ligand-receptor interaction    Estrogen signaling pathway    Morphine addiction   
NDEx NetworkOPRM1
Atlas of Cancer Signalling NetworkOPRM1
Wikipedia pathwaysOPRM1
Orthology - Evolution
OrthoDB4988
GeneTree (enSembl)ENSG00000112038
Phylogenetic Trees/Animal Genes : TreeFamOPRM1
HOVERGENP35372
HOGENOMP35372
Homologs : HomoloGeneOPRM1
Homology/Alignments : Family Browser (UCSC)OPRM1
Gene fusions - Rearrangements
Fusion : QuiverOPRM1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOPRM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OPRM1
dbVarOPRM1
ClinVarOPRM1
1000_GenomesOPRM1 
Exome Variant ServerOPRM1
ExAC (Exome Aggregation Consortium)ENSG00000112038
GNOMAD BrowserENSG00000112038
Varsome BrowserOPRM1
Genetic variants : HAPMAP4988
Genomic Variants (DGV)OPRM1 [DGVbeta]
DECIPHEROPRM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOPRM1 
Mutations
ICGC Data PortalOPRM1 
TCGA Data PortalOPRM1 
Broad Tumor PortalOPRM1
OASIS PortalOPRM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOPRM1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOPRM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OPRM1
DgiDB (Drug Gene Interaction Database)OPRM1
DoCM (Curated mutations)OPRM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OPRM1 (select a term)
intoGenOPRM1
Cancer3DOPRM1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600018   
Orphanet
DisGeNETOPRM1
MedgenOPRM1
Genetic Testing Registry OPRM1
NextProtP35372 [Medical]
TSGene4988
GENETestsOPRM1
Target ValidationOPRM1
Huge Navigator OPRM1 [HugePedia]
snp3D : Map Gene to Disease4988
BioCentury BCIQOPRM1
ClinGenOPRM1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4988
Chemical/Pharm GKB GenePA31945
Clinical trialOPRM1
Miscellaneous
canSAR (ICR)OPRM1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOPRM1
EVEXOPRM1
GoPubMedOPRM1
iHOPOPRM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:27:44 CET 2018

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