Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

OPTN (optineurin)

Identity

Other namesALS12
FIP2
GLC1E
HIP7
HYPL
NRP
TFIIIA-INTP
HGNC (Hugo) OPTN
LocusID (NCBI) 10133
Location 10p13
Location_base_pair Starts at 13142082 and ends at 13180276 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)OPTN   17142
Entrez_Gene (NCBI)OPTN  10133  optineurin
Cards
GeneCards (Weizmann)OPTN
Ensembl (Hinxton)ENSG00000123240 [Gene_View]  chr10:13142082-13180276 [Contig_View]  OPTN [Vega]
AceView (NCBI)OPTN
Genatlas (Paris)OPTN
SOURCE (Stanford)NM_001008211 NM_001008212 NM_001008213 NM_021980
Genomic and cartography
GoldenPath (UCSC)OPTN  -  10p13   chr10:13142082-13180276 +  10p13   [Description]    (hg19-Feb_2009)
EnsemblOPTN - 10p13 [CytoView]
Mapping of homologs : NCBIOPTN [Mapview]
OMIM137760   602432   606657   613435   
Gene and transcription
Genbank (Entrez)AF049614 AF061034 AF061034 AF070533 AF420371
RefSeq transcript (SRS)NM_001008211 NM_001008212 NM_001008213 NM_021980
RefSeq transcript (Entrez)NM_001008211 NM_001008212 NM_001008213 NM_021980
RefSeq genomic (SRS)AC_000142 NC_000010 NC_018921 NG_012876 NT_008705 NW_001837931 NW_004929370
RefSeq genomic (Entrez)AC_000142 NC_000010 NC_018921 NG_012876 NT_008705 NW_001837931 NW_004929370
Consensus coding sequences : CCDS (NCBI)OPTN
Cluster EST : UnigeneHs.332706 [ SRS ] Hs.332706 [ NCBI ]
CGAP (NCI)Hs.332706
Alternative Splicing : Fast-db (Paris)GSHG0003210
Alternative Splicing GalleryENSG00000123240
Gene ExpressionOPTN [ NCBI-GEO ]   OPTN [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96CV9 (SRS) Q96CV9 (Uniprot)
NextProtQ96CV9  [Medical]
With graphics : InterProQ96CV9
Splice isoforms : SwissVarQ96CV9(Swissvar)
Domains : Interpro (SRS)NEMO_N   
Domains : Interpro (EBI)NEMO_N   
Related proteins : CluSTrQ96CV9
Domain families : Pfam (SRS)NEMO (PF11577)   
Domain families : Pfam (Sanger)NEMO (PF11577)   
Domain families : Pfam (NCBI)pfam11577   
DMDM10133
Blocks (Seattle)Q96CV9
PDB (SRS)2LO4    2LUE    3VTV    3VTW   
PDB (PDBSum)2LO4    2LUE    3VTV    3VTW   
PDB (IMB)2LO4    2LUE    3VTV    3VTW   
PDB (RSDB)2LO4    2LUE    3VTV    3VTW   
Human Protein AtlasENSG00000123240
HPRD03891
IPIIPI00304189   IPI00554537   IPI00514792   IPI00645442   
Protein Interaction databases
DIP (DOE-UCLA)Q96CV9
IntAct (EBI)Q96CV9
FunCoupENSG00000123240
REACTOMEOPTN
Protein Interaction Database10133
BioGRIDOPTN
InParanoidQ96CV9
Interologous Interaction database Q96CV9
IntegromeDBOPTN
Gene fusion - rearrangments
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)OPTN
SNP (GeneSNP Utah)OPTN
SNP : HGBaseOPTN
Genetic variants : HAPMAPOPTN
Somatic Mutations in Cancer : COSMICOPTN 
CONAN: Copy Number AnalysisOPTN 
Mutations and Diseases : HGMDOPTN
OMIM137760    602432    606657    613435   
GENETests137760    602432    606657    613435   
Disease Genetic AssociationOPTN
Huge Navigator OPTN [HugePedia]  OPTN [HugeCancerGEM]
Genomic VariantsOPTN  OPTN [DGVbeta]
ClinVarOPTN
snp3D : Map Gene to Disease10133
General knowledge
Homologs : HomoloGeneOPTN
Homology/Alignments : Family Browser (UCSC)OPTN
Phylogenetic Trees/Animal Genes : TreeFamOPTN
Chemical/Protein Interactions : CTD10133
Chemical/Pharm GKB GenePA31948
Clinical trialOPTN
Cancer Resource (Charite)ENSG00000123240
Ontology : AmiGOprotein targeting to Golgi  G2/M transition of mitotic cell cycle  Golgi membrane  mitotic cell cycle  protein binding  nucleoplasm  cytoplasm  Golgi apparatus  trans-Golgi network  cytosol  Golgi organization  signal transduction  protein C-terminus binding  cell death  Golgi to plasma membrane protein transport  perinuclear region of cytoplasm  Golgi ribbon formation  
Ontology : EGO-EBIprotein targeting to Golgi  G2/M transition of mitotic cell cycle  Golgi membrane  mitotic cell cycle  protein binding  nucleoplasm  cytoplasm  Golgi apparatus  trans-Golgi network  cytosol  Golgi organization  signal transduction  protein C-terminus binding  cell death  Golgi to plasma membrane protein transport  perinuclear region of cytoplasm  Golgi ribbon formation  
Other databases
Probes
Litterature
PubMed141 Pubmed reference(s) in Entrez
PubGeneOPTN
iHOPOPTN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Dec 3 19:56:13 CET 2013
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.