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ORAI1 (ORAI calcium release-activated calcium modulator 1)

Identity

Alias_namesTMEM142A
transmembrane protein 142A
Alias_symbol (synonym)FLJ14466
CRACM1
Other aliasIMD9
ORAT1
TAM2
HGNC (Hugo) ORAI1
LocusID (NCBI) 84876
Atlas_Id 46187
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 121626550 and ends at 121642040 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ORAI1   25896
LRG (Locus Reference Genomic)LRG_93
Cards
Entrez_Gene (NCBI)ORAI1  84876  ORAI calcium release-activated calcium modulator 1
AliasesCRACM1; IMD9; ORAT1; TAM2; 
TMEM142A
GeneCards (Weizmann)ORAI1
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr12:121626550-121642040 [Contig_View]  ORAI1 [Vega]
TCGA cBioPortalORAI1
AceView (NCBI)ORAI1
Genatlas (Paris)ORAI1
WikiGenes84876
SOURCE (Princeton)ORAI1
Genetics Home Reference (NIH)ORAI1
Genomic and cartography
GoldenPath hg38 (UCSC)ORAI1  -     chr12:121626550-121642040 +  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ORAI1  -     12q24.31   [Description]    (hg19-Feb_2009)
EnsemblORAI1 - 12q24.31 [CytoView hg19]  ORAI1 - 12q24.31 [CytoView hg38]
Mapping of homologs : NCBIORAI1 [Mapview hg19]  ORAI1 [Mapview hg38]
OMIM610277   612782   615883   
Gene and transcription
Genbank (Entrez)AK027372 BC013386 BC015369 BC075831 BC104633
RefSeq transcript (Entrez)NM_032790
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ORAI1
Cluster EST : UnigeneHs.55148 [ NCBI ]
CGAP (NCI)Hs.55148
Gene ExpressionORAI1 [ NCBI-GEO ]   ORAI1 [ EBI - ARRAY_EXPRESS ]   ORAI1 [ SEEK ]   ORAI1 [ MEM ]
Gene Expression Viewer (FireBrowse)ORAI1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84876
GTEX Portal (Tissue expression)ORAI1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96D31   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96D31  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96D31
Splice isoforms : SwissVarQ96D31
PhosPhoSitePlusQ96D31
Domains : Interpro (EBI)CRAC_channel   
Domain families : Pfam (Sanger)Orai-1 (PF07856)   
Domain families : Pfam (NCBI)pfam07856   
Conserved Domain (NCBI)ORAI1
DMDM Disease mutations84876
Blocks (Seattle)ORAI1
PDB (SRS)2MAK    4EHQ   
PDB (PDBSum)2MAK    4EHQ   
PDB (IMB)2MAK    4EHQ   
PDB (RSDB)2MAK    4EHQ   
Structural Biology KnowledgeBase2MAK    4EHQ   
SCOP (Structural Classification of Proteins)2MAK    4EHQ   
CATH (Classification of proteins structures)2MAK    4EHQ   
SuperfamilyQ96D31
Peptide AtlasQ96D31
HPRD08599
IPIIPI00303699   IPI01009662   
Protein Interaction databases
DIP (DOE-UCLA)Q96D31
IntAct (EBI)Q96D31
BioGRIDORAI1
STRING (EMBL)ORAI1
ZODIACORAI1
Ontologies - Pathways
QuickGOQ96D31
Ontology : AmiGOstore-operated calcium entry  adaptive immune response  protein binding  calmodulin binding  integral component of plasma membrane  store-operated calcium channel activity  membrane  identical protein binding  regulation of calcium ion transport  positive regulation of calcium ion transport  calcium ion transmembrane transport  
Ontology : EGO-EBIstore-operated calcium entry  adaptive immune response  protein binding  calmodulin binding  integral component of plasma membrane  store-operated calcium channel activity  membrane  identical protein binding  regulation of calcium ion transport  positive regulation of calcium ion transport  calcium ion transmembrane transport  
Pathways : KEGGCalcium signaling pathway    Primary immunodeficiency   
NDEx NetworkORAI1
Atlas of Cancer Signalling NetworkORAI1
Wikipedia pathwaysORAI1
Orthology - Evolution
OrthoDB84876
Phylogenetic Trees/Animal Genes : TreeFamORAI1
HOVERGENQ96D31
HOGENOMQ96D31
Homologs : HomoloGeneORAI1
Homology/Alignments : Family Browser (UCSC)ORAI1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerORAI1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ORAI1
dbVarORAI1
ClinVarORAI1
1000_GenomesORAI1 
Exome Variant ServerORAI1
ExAC (Exome Aggregation Consortium)ORAI1 (select the gene name)
Genetic variants : HAPMAP84876
Genomic Variants (DGV)ORAI1 [DGVbeta]
DECIPHERORAI1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisORAI1 
Mutations
ICGC Data PortalORAI1 
TCGA Data PortalORAI1 
Broad Tumor PortalORAI1
OASIS PortalORAI1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDORAI1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch ORAI1
DgiDB (Drug Gene Interaction Database)ORAI1
DoCM (Curated mutations)ORAI1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ORAI1 (select a term)
intoGenORAI1
Cancer3DORAI1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610277    612782    615883   
Orphanet2388    21581   
MedgenORAI1
Genetic Testing Registry ORAI1
NextProtQ96D31 [Medical]
TSGene84876
GENETestsORAI1
Target ValidationORAI1
Huge Navigator ORAI1 [HugePedia]
snp3D : Map Gene to Disease84876
BioCentury BCIQORAI1
ClinGenORAI1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84876
Chemical/Pharm GKB GenePA162398445
Clinical trialORAI1
Miscellaneous
canSAR (ICR)ORAI1 (select the gene name)
Probes
Litterature
PubMed232 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineORAI1
EVEXORAI1
GoPubMedORAI1
iHOPORAI1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:48:02 CEST 2017

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