Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ORAI2 (ORAI calcium release-activated calcium modulator 2)

Identity

Alias_namesC7orf19
TMEM142B
chromosome 7 open reading frame 19
transmembrane protein 142B
Alias_symbol (synonym)CBCIP2
FLJ12474
FLJ14733
H_NH0514P08.8
Other aliasMEM142B
HGNC (Hugo) ORAI2
LocusID (NCBI) 80228
Atlas_Id 71544
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 102073977 and ends at 102097268 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CD3E (11q23.3) / ORAI2 (7q22.1)HLA-B (6p21.33) / ORAI2 (7q22.1)ORAI2 (7q22.1) / CUX1 (7q22.1)
ORAI2 (7q22.1) / WHSC1 (4p16.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ORAI2   21667
Cards
Entrez_Gene (NCBI)ORAI2  80228  ORAI calcium release-activated calcium modulator 2
AliasesC7orf19; CBCIP2; MEM142B; TMEM142B
GeneCards (Weizmann)ORAI2
Ensembl hg19 (Hinxton)ENSG00000160991 [Gene_View]  chr7:102073977-102097268 [Contig_View]  ORAI2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000160991 [Gene_View]  chr7:102073977-102097268 [Contig_View]  ORAI2 [Vega]
ICGC DataPortalENSG00000160991
TCGA cBioPortalORAI2
AceView (NCBI)ORAI2
Genatlas (Paris)ORAI2
WikiGenes80228
SOURCE (Princeton)ORAI2
Genetics Home Reference (NIH)ORAI2
Genomic and cartography
GoldenPath hg19 (UCSC)ORAI2  -     chr7:102073977-102097268 +  7q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ORAI2  -     7q22.1   [Description]    (hg38-Dec_2013)
EnsemblORAI2 - 7q22.1 [CytoView hg19]  ORAI2 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBIORAI2 [Mapview hg19]  ORAI2 [Mapview hg38]
OMIM610929   
Gene and transcription
Genbank (Entrez)AF258552 AK022536 AK027639 AK056497 AK128753
RefSeq transcript (Entrez)NM_001126340 NM_001271818 NM_001271819 NM_032831
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)ORAI2
Cluster EST : UnigeneHs.736659 [ NCBI ]
CGAP (NCI)Hs.736659
Alternative Splicing GalleryENSG00000160991
Gene ExpressionORAI2 [ NCBI-GEO ]   ORAI2 [ EBI - ARRAY_EXPRESS ]   ORAI2 [ SEEK ]   ORAI2 [ MEM ]
Gene Expression Viewer (FireBrowse)ORAI2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80228
GTEX Portal (Tissue expression)ORAI2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96SN7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96SN7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96SN7
Splice isoforms : SwissVarQ96SN7
PhosPhoSitePlusQ96SN7
Domains : Interpro (EBI)CRAC_channel    Orai-2   
Domain families : Pfam (Sanger)Orai-1 (PF07856)   
Domain families : Pfam (NCBI)pfam07856   
Conserved Domain (NCBI)ORAI2
DMDM Disease mutations80228
Blocks (Seattle)ORAI2
SuperfamilyQ96SN7
Human Protein AtlasENSG00000160991
Peptide AtlasQ96SN7
HPRD09860
IPIIPI00045842   IPI00947153   IPI00946299   IPI00946990   IPI00946414   
Protein Interaction databases
DIP (DOE-UCLA)Q96SN7
IntAct (EBI)Q96SN7
FunCoupENSG00000160991
BioGRIDORAI2
STRING (EMBL)ORAI2
ZODIACORAI2
Ontologies - Pathways
QuickGOQ96SN7
Ontology : AmiGOstore-operated calcium entry  protein binding  store-operated calcium channel activity  membrane  integral component of membrane  growth cone  calcium ion transmembrane transport  
Ontology : EGO-EBIstore-operated calcium entry  protein binding  store-operated calcium channel activity  membrane  integral component of membrane  growth cone  calcium ion transmembrane transport  
Pathways : KEGGCalcium signaling pathway   
NDEx NetworkORAI2
Atlas of Cancer Signalling NetworkORAI2
Wikipedia pathwaysORAI2
Orthology - Evolution
OrthoDB80228
GeneTree (enSembl)ENSG00000160991
Phylogenetic Trees/Animal Genes : TreeFamORAI2
HOVERGENQ96SN7
HOGENOMQ96SN7
Homologs : HomoloGeneORAI2
Homology/Alignments : Family Browser (UCSC)ORAI2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerORAI2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ORAI2
dbVarORAI2
ClinVarORAI2
1000_GenomesORAI2 
Exome Variant ServerORAI2
ExAC (Exome Aggregation Consortium)ORAI2 (select the gene name)
Genetic variants : HAPMAP80228
Genomic Variants (DGV)ORAI2 [DGVbeta]
DECIPHER (Syndromes)7:102073977-102097268  ENSG00000160991
CONAN: Copy Number AnalysisORAI2 
Mutations
ICGC Data PortalORAI2 
TCGA Data PortalORAI2 
Broad Tumor PortalORAI2
OASIS PortalORAI2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICORAI2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDORAI2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ORAI2
DgiDB (Drug Gene Interaction Database)ORAI2
DoCM (Curated mutations)ORAI2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ORAI2 (select a term)
intoGenORAI2
Cancer3DORAI2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610929   
Orphanet
MedgenORAI2
Genetic Testing Registry ORAI2
NextProtQ96SN7 [Medical]
TSGene80228
GENETestsORAI2
Huge Navigator ORAI2 [HugePedia]
snp3D : Map Gene to Disease80228
BioCentury BCIQORAI2
ClinGenORAI2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80228
Chemical/Pharm GKB GenePA162398454
Clinical trialORAI2
Miscellaneous
canSAR (ICR)ORAI2 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineORAI2
EVEXORAI2
GoPubMedORAI2
iHOPORAI2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 12:37:25 CET 2017

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