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ORAI2 (ORAI calcium release-activated calcium modulator 2)

Identity

Alias (NCBI)C7orf19
CBCIP2
MEM142B
TMEM142B
HGNC (Hugo) ORAI2
HGNC Alias symbCBCIP2
FLJ12474
FLJ14733
H_NH0514P08.8
HGNC Alias nameCAP-binding protein complex interacting protein 2
HGNC Previous nameC7orf19
 TMEM142B
HGNC Previous namechromosome 7 open reading frame 19
 transmembrane protein 142B
LocusID (NCBI) 80228
Atlas_Id 71544
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 102433575 and ends at 102456823 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD3E (11q23.3) / ORAI2 (7q22.1)HLA-B (6p21.33) / ORAI2 (7q22.1)ORAI2 (7q22.1) / CUX1 (7q22.1)
ORAI2 (7q22.1) / WHSC1 (4p16.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ORAI2   21667
Cards
Entrez_Gene (NCBI)ORAI2    ORAI calcium release-activated calcium modulator 2
AliasesC7orf19; CBCIP2; MEM142B; TMEM142B
GeneCards (Weizmann)ORAI2
Ensembl hg19 (Hinxton)ENSG00000160991 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160991 [Gene_View]  ENSG00000160991 [Sequence]  chr7:102433575-102456823 [Contig_View]  ORAI2 [Vega]
ICGC DataPortalENSG00000160991
TCGA cBioPortalORAI2
AceView (NCBI)ORAI2
Genatlas (Paris)ORAI2
SOURCE (Princeton)ORAI2
Genetics Home Reference (NIH)ORAI2
Genomic and cartography
GoldenPath hg38 (UCSC)ORAI2  -     chr7:102433575-102456823 +  7q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ORAI2  -     7q22.1   [Description]    (hg19-Feb_2009)
GoldenPathORAI2 - 7q22.1 [CytoView hg19]  ORAI2 - 7q22.1 [CytoView hg38]
ImmunoBaseENSG00000160991
Genome Data Viewer NCBIORAI2 [Mapview hg19]  
OMIM610929   
Gene and transcription
Genbank (Entrez)AF258552 AK022536 AK027639 AK056497 AK128753
RefSeq transcript (Entrez)NM_001126340 NM_001271818 NM_001271819 NM_032831
Consensus coding sequences : CCDS (NCBI)ORAI2
Gene ExpressionORAI2 [ NCBI-GEO ]   ORAI2 [ EBI - ARRAY_EXPRESS ]   ORAI2 [ SEEK ]   ORAI2 [ MEM ]
Gene Expression Viewer (FireBrowse)ORAI2 [ Firebrowse - Broad ]
GenevisibleExpression of ORAI2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80228
GTEX Portal (Tissue expression)ORAI2
Human Protein AtlasENSG00000160991-ORAI2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96SN7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96SN7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96SN7
PhosPhoSitePlusQ96SN7
Domains : Interpro (EBI)CRAC_channel    Orai-2    Orai_sf   
Domain families : Pfam (Sanger)Orai-1 (PF07856)   
Domain families : Pfam (NCBI)pfam07856   
Conserved Domain (NCBI)ORAI2
SuperfamilyQ96SN7
AlphaFold pdb e-kbQ96SN7   
Human Protein Atlas [tissue]ENSG00000160991-ORAI2 [tissue]
HPRD09860
Protein Interaction databases
DIP (DOE-UCLA)Q96SN7
IntAct (EBI)Q96SN7
BioGRIDORAI2
STRING (EMBL)ORAI2
ZODIACORAI2
Ontologies - Pathways
QuickGOQ96SN7
Ontology : AmiGOstore-operated calcium entry  protein binding  store-operated calcium channel activity  membrane  integral component of membrane  calcium ion transmembrane transport  
Ontology : EGO-EBIstore-operated calcium entry  protein binding  store-operated calcium channel activity  membrane  integral component of membrane  calcium ion transmembrane transport  
NDEx NetworkORAI2
Atlas of Cancer Signalling NetworkORAI2
Wikipedia pathwaysORAI2
Orthology - Evolution
OrthoDB80228
GeneTree (enSembl)ENSG00000160991
Phylogenetic Trees/Animal Genes : TreeFamORAI2
Homologs : HomoloGeneORAI2
Homology/Alignments : Family Browser (UCSC)ORAI2
Gene fusions - Rearrangements
Fusion : QuiverORAI2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerORAI2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ORAI2
dbVarORAI2
ClinVarORAI2
MonarchORAI2
1000_GenomesORAI2 
Exome Variant ServerORAI2
GNOMAD BrowserENSG00000160991
Varsome BrowserORAI2
ACMGORAI2 variants
VarityQ96SN7
Genomic Variants (DGV)ORAI2 [DGVbeta]
DECIPHERORAI2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisORAI2 
Mutations
ICGC Data PortalORAI2 
TCGA Data PortalORAI2 
Broad Tumor PortalORAI2
OASIS PortalORAI2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICORAI2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DORAI2
Mutations and Diseases : HGMDORAI2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaORAI2
DgiDB (Drug Gene Interaction Database)ORAI2
DoCM (Curated mutations)ORAI2
CIViC (Clinical Interpretations of Variants in Cancer)ORAI2
Cancer3DORAI2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610929   
Orphanet
DisGeNETORAI2
MedgenORAI2
Genetic Testing Registry ORAI2
NextProtQ96SN7 [Medical]
GENETestsORAI2
Target ValidationORAI2
Huge Navigator ORAI2 [HugePedia]
ClinGenORAI2
Clinical trials, drugs, therapy
MyCancerGenomeORAI2
Protein Interactions : CTDORAI2
Pharm GKB GenePA162398454
PharosQ96SN7
Clinical trialORAI2
Miscellaneous
canSAR (ICR)ORAI2
HarmonizomeORAI2
DataMed IndexORAI2
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXORAI2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:15:06 CEST 2021

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