Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ORC1 (origin recognition complex, subunit 1)

Identity

Other namesHSORC1
ORC1L
PARC1
HGNC (Hugo) ORC1
LocusID (NCBI) 4998
Atlas_Id 52158
Location 1p32.3
Location_base_pair Starts at 52838501 and ends at 52870143 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ORC1   8487
Cards
Entrez_Gene (NCBI)ORC1  4998  origin recognition complex, subunit 1
GeneCards (Weizmann)ORC1
Ensembl hg19 (Hinxton)ENSG00000085840 [Gene_View]  chr1:52838501-52870143 [Contig_View]  ORC1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000085840 [Gene_View]  chr1:52838501-52870143 [Contig_View]  ORC1 [Vega]
ICGC DataPortalENSG00000085840
TCGA cBioPortalORC1
AceView (NCBI)ORC1
Genatlas (Paris)ORC1
WikiGenes4998
SOURCE (Princeton)ORC1
Genomic and cartography
GoldenPath hg19 (UCSC)ORC1  -     chr1:52838501-52870143 -  1p32.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ORC1  -     1p32.3   [Description]    (hg38-Dec_2013)
EnsemblORC1 - 1p32.3 [CytoView hg19]  ORC1 - 1p32.3 [CytoView hg38]
Mapping of homologs : NCBIORC1 [Mapview hg19]  ORC1 [Mapview hg38]
OMIM224690   601902   
Gene and transcription
Genbank (Entrez)AK291909 AK303420 BC011539 BP280383 DB156841
RefSeq transcript (Entrez)NM_001190818 NM_001190819 NM_004153
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_028251 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)ORC1
Cluster EST : UnigeneHs.17908 [ NCBI ]
CGAP (NCI)Hs.17908
Alternative Splicing : Fast-db (Paris)GSHG0002104
Alternative Splicing GalleryENSG00000085840
Gene ExpressionORC1 [ NCBI-GEO ]     ORC1 [ SEEK ]   ORC1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13415 (Uniprot)
NextProtQ13415  [Medical]
With graphics : InterProQ13415
Splice isoforms : SwissVarQ13415 (Swissvar)
Domaine pattern : Prosite (Expaxy)BAH (PS51038)   
Domains : Interpro (EBI)AAA+_ATPase    ATPase_AAA_core    BAH_dom    Cdc6_C_dom    P-loop_NTPase    WHTH_DNA-bd_dom   
Related proteins : CluSTrQ13415
Domain families : Pfam (Sanger)AAA (PF00004)    BAH (PF01426)    Cdc6_C (PF09079)   
Domain families : Pfam (NCBI)pfam00004    pfam01426    pfam09079   
Domain families : Smart (EMBL)AAA (SM00382)  BAH (SM00439)  Cdc6_C (SM01074)  
DMDM Disease mutations4998
Blocks (Seattle)Q13415
Human Protein AtlasENSG00000085840
Peptide AtlasQ13415
HPRD03544
IPIIPI00013215   IPI00975911   
Protein Interaction databases
DIP (DOE-UCLA)Q13415
IntAct (EBI)Q13415
FunCoupENSG00000085840
BioGRIDORC1
IntegromeDBORC1
STRING (EMBL)ORC1
Ontologies - Pathways
QuickGOQ13415
Ontology : AmiGOG1/S transition of mitotic cell cycle  regulation of transcription involved in G1/S transition of mitotic cell cycle  mitotic cell cycle  origin recognition complex  DNA binding  chromatin binding  protein binding  ATP binding  nucleus  nucleoplasm  nuclear origin of replication recognition complex  nucleolus  cytoplasm  cytosol  plasma membrane  DNA replication  DNA replication initiation  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  regulation of transcription involved in G1/S transition of mitotic cell cycle  mitotic cell cycle  origin recognition complex  DNA binding  chromatin binding  protein binding  ATP binding  nucleus  nucleoplasm  nuclear origin of replication recognition complex  nucleolus  cytoplasm  cytosol  plasma membrane  DNA replication  DNA replication initiation  
Pathways : BIOCARTACDK Regulation of DNA Replication [Genes]   
Pathways : KEGGCell cycle   
Protein Interaction DatabaseORC1
DoCM (Curated mutations)ORC1
Wikipedia pathwaysORC1
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerORC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ORC1
dbVarORC1
ClinVarORC1
1000_GenomesORC1 
Exome Variant ServerORC1
SNP (GeneSNP Utah)ORC1
SNP : HGBaseORC1
Genetic variants : HAPMAPORC1
Genomic Variants (DGV)ORC1 [DGVbeta]
Mutations
ICGC Data PortalORC1 
TCGA Data PortalORC1 
Tumor PortalORC1
Somatic Mutations in Cancer : COSMICORC1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:52838501-52870143
CONAN: Copy Number AnalysisORC1 
Mutations and Diseases : HGMDORC1
OMIM224690    601902   
MedgenORC1
NextProtQ13415 [Medical]
GENETestsORC1
Disease Genetic AssociationORC1
Huge Navigator ORC1 [HugePedia]  ORC1 [HugeCancerGEM]
snp3D : Map Gene to Disease4998
DGIdb (Drug Gene Interaction db)ORC1
General knowledge
Homologs : HomoloGeneORC1
Homology/Alignments : Family Browser (UCSC)ORC1
Phylogenetic Trees/Animal Genes : TreeFamORC1
Chemical/Protein Interactions : CTD4998
Chemical/Pharm GKB GenePA32808
Clinical trialORC1
Cancer Resource (Charite)ENSG00000085840
Other databases
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
CoreMineORC1
GoPubMedORC1
iHOPORC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 14:56:17 CEST 2015

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