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ORC2 (origin recognition complex subunit 2)

Identity

Alias_namesORC2L
origin recognition complex, subunit 2 (yeast homolog)-like
origin recognition complex, subunit 2-like (yeast)
origin recognition complex, subunit 2 homolog (yeast)
origin recognition complex, subunit 2
Other alias
HGNC (Hugo) ORC2
LocusID (NCBI) 4999
Atlas_Id 43387
Location 2q33.1  [Link to chromosome band 2q33]
Location_base_pair Starts at 201774894 and ends at 201828424 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FAM126B (2q33.1) / ORC2 (2q33.1)ORC2 (2q33.1) / ALS2CR12 (2q33.1)ORC2 (2q33.1) / ORC2 (2q33.1)
ORC2 2q33.1 / ALS2CR12 2q33.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ORC2   8488
Cards
Entrez_Gene (NCBI)ORC2  4999  origin recognition complex subunit 2
AliasesORC2L
GeneCards (Weizmann)ORC2
Ensembl hg19 (Hinxton)ENSG00000115942 [Gene_View]  chr2:201774894-201828424 [Contig_View]  ORC2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000115942 [Gene_View]  chr2:201774894-201828424 [Contig_View]  ORC2 [Vega]
ICGC DataPortalENSG00000115942
TCGA cBioPortalORC2
AceView (NCBI)ORC2
Genatlas (Paris)ORC2
WikiGenes4999
SOURCE (Princeton)ORC2
Genetics Home Reference (NIH)ORC2
Genomic and cartography
GoldenPath hg19 (UCSC)ORC2  -     chr2:201774894-201828424 -  2q33.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ORC2  -     2q33.1   [Description]    (hg38-Dec_2013)
EnsemblORC2 - 2q33.1 [CytoView hg19]  ORC2 - 2q33.1 [CytoView hg38]
Mapping of homologs : NCBIORC2 [Mapview hg19]  ORC2 [Mapview hg38]
OMIM601182   
Gene and transcription
Genbank (Entrez)AI033876 AK302614 AK316433 BC014834 BM470184
RefSeq transcript (Entrez)NM_006190
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)ORC2
Cluster EST : UnigeneHs.444870 [ NCBI ]
CGAP (NCI)Hs.444870
Alternative Splicing GalleryENSG00000115942
Gene ExpressionORC2 [ NCBI-GEO ]   ORC2 [ EBI - ARRAY_EXPRESS ]   ORC2 [ SEEK ]   ORC2 [ MEM ]
Gene Expression Viewer (FireBrowse)ORC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4999
GTEX Portal (Tissue expression)ORC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13416   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13416  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13416
Splice isoforms : SwissVarQ13416
PhosPhoSitePlusQ13416
Domains : Interpro (EBI)ORC2   
Domain families : Pfam (Sanger)ORC2 (PF04084)   
Domain families : Pfam (NCBI)pfam04084   
Conserved Domain (NCBI)ORC2
DMDM Disease mutations4999
Blocks (Seattle)ORC2
PDB (SRS)5C8H   
PDB (PDBSum)5C8H   
PDB (IMB)5C8H   
PDB (RSDB)5C8H   
Structural Biology KnowledgeBase5C8H   
SCOP (Structural Classification of Proteins)5C8H   
CATH (Classification of proteins structures)5C8H   
SuperfamilyQ13416
Human Protein AtlasENSG00000115942
Peptide AtlasQ13416
HPRD03112
IPIIPI00013216   IPI00917775   IPI00917910   
Protein Interaction databases
DIP (DOE-UCLA)Q13416
IntAct (EBI)Q13416
FunCoupENSG00000115942
BioGRIDORC2
STRING (EMBL)ORC2
ZODIACORC2
Ontologies - Pathways
QuickGOQ13416
Ontology : AmiGOG1/S transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  nuclear chromosome, telomeric region  nuclear chromosome, telomeric region  heterochromatin  origin recognition complex  condensed chromosome inner kinetochore  DNA replication origin binding  protein binding  nucleus  nucleoplasm  nuclear origin of replication recognition complex  centrosome  DNA replication  DNA replication initiation  membrane  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  nuclear chromosome, telomeric region  nuclear chromosome, telomeric region  heterochromatin  origin recognition complex  condensed chromosome inner kinetochore  DNA replication origin binding  protein binding  nucleus  nucleoplasm  nuclear origin of replication recognition complex  centrosome  DNA replication  DNA replication initiation  membrane  
Pathways : BIOCARTACDK Regulation of DNA Replication [Genes]   
Pathways : KEGGCell cycle   
NDEx NetworkORC2
Atlas of Cancer Signalling NetworkORC2
Wikipedia pathwaysORC2
Orthology - Evolution
OrthoDB4999
GeneTree (enSembl)ENSG00000115942
Phylogenetic Trees/Animal Genes : TreeFamORC2
HOVERGENQ13416
HOGENOMQ13416
Homologs : HomoloGeneORC2
Homology/Alignments : Family Browser (UCSC)ORC2
Gene fusions - Rearrangements
Fusion : MitelmanORC2/ALS2CR12 [2q33.1/2q33.1]  
Fusion: TCGAORC2 2q33.1 ALS2CR12 2q33.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerORC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ORC2
dbVarORC2
ClinVarORC2
1000_GenomesORC2 
Exome Variant ServerORC2
ExAC (Exome Aggregation Consortium)ORC2 (select the gene name)
Genetic variants : HAPMAP4999
Genomic Variants (DGV)ORC2 [DGVbeta]
DECIPHER (Syndromes)2:201774894-201828424  ENSG00000115942
CONAN: Copy Number AnalysisORC2 
Mutations
ICGC Data PortalORC2 
TCGA Data PortalORC2 
Broad Tumor PortalORC2
OASIS PortalORC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICORC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDORC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ORC2
DgiDB (Drug Gene Interaction Database)ORC2
DoCM (Curated mutations)ORC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ORC2 (select a term)
intoGenORC2
Cancer3DORC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601182   
Orphanet
MedgenORC2
Genetic Testing Registry ORC2
NextProtQ13416 [Medical]
TSGene4999
GENETestsORC2
Huge Navigator ORC2 [HugePedia]
snp3D : Map Gene to Disease4999
BioCentury BCIQORC2
ClinGenORC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4999
Chemical/Pharm GKB GenePA32809
Clinical trialORC2
Miscellaneous
canSAR (ICR)ORC2 (select the gene name)
Probes
Litterature
PubMed74 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineORC2
EVEXORC2
GoPubMedORC2
iHOPORC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:19:54 CET 2017

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