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ORC3 (origin recognition complex subunit 3)

Identity

Alias_namesORC3L
origin recognition complex, subunit 3 (yeast homolog)-like
origin recognition complex, subunit 3-like (yeast)
origin recognition complex, subunit 3 honolog (yeast)
origin recognition complex, subunit 3
Alias_symbol (synonym)IMAGE50150
LATHEO
Other aliasLAT
HGNC (Hugo) ORC3
LocusID (NCBI) 23595
Atlas_Id 56028
Location 6q15  [Link to chromosome band 6q15]
Location_base_pair Starts at 87590067 and ends at 87667454 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ORC3 (6q15) / CTDP1 (18q23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ORC3   8489
Cards
Entrez_Gene (NCBI)ORC3  23595  origin recognition complex subunit 3
AliasesLAT; LATHEO; ORC3L
GeneCards (Weizmann)ORC3
Ensembl hg19 (Hinxton)ENSG00000135336 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135336 [Gene_View]  ENSG00000135336 [Sequence]  chr6:87590067-87667454 [Contig_View]  ORC3 [Vega]
ICGC DataPortalENSG00000135336
TCGA cBioPortalORC3
AceView (NCBI)ORC3
Genatlas (Paris)ORC3
WikiGenes23595
SOURCE (Princeton)ORC3
Genetics Home Reference (NIH)ORC3
Genomic and cartography
GoldenPath hg38 (UCSC)ORC3  -     chr6:87590067-87667454 +  6q15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ORC3  -     6q15   [Description]    (hg19-Feb_2009)
EnsemblORC3 - 6q15 [CytoView hg19]  ORC3 - 6q15 [CytoView hg38]
Mapping of homologs : NCBIORC3 [Mapview hg19]  ORC3 [Mapview hg38]
OMIM604972   
Gene and transcription
Genbank (Entrez)AF093535 AF125507 AF135044 AK094135 AK222795
RefSeq transcript (Entrez)NM_001197259 NM_012381 NM_181837
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ORC3
Cluster EST : UnigeneHs.410228 [ NCBI ]
CGAP (NCI)Hs.410228
Alternative Splicing GalleryENSG00000135336
Gene ExpressionORC3 [ NCBI-GEO ]   ORC3 [ EBI - ARRAY_EXPRESS ]   ORC3 [ SEEK ]   ORC3 [ MEM ]
Gene Expression Viewer (FireBrowse)ORC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23595
GTEX Portal (Tissue expression)ORC3
Human Protein AtlasENSG00000135336-ORC3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBD5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBD5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBD5
Splice isoforms : SwissVarQ9UBD5
PhosPhoSitePlusQ9UBD5
Domains : Interpro (EBI)ORC3   
Domain families : Pfam (Sanger)ORC3_N (PF07034)   
Domain families : Pfam (NCBI)pfam07034   
Conserved Domain (NCBI)ORC3
DMDM Disease mutations23595
Blocks (Seattle)ORC3
PDB (SRS)5UJ8    5UJM   
PDB (PDBSum)5UJ8    5UJM   
PDB (IMB)5UJ8    5UJM   
PDB (RSDB)5UJ8    5UJM   
Structural Biology KnowledgeBase5UJ8    5UJM   
SCOP (Structural Classification of Proteins)5UJ8    5UJM   
CATH (Classification of proteins structures)5UJ8    5UJM   
SuperfamilyQ9UBD5
Human Protein Atlas [tissue]ENSG00000135336-ORC3 [tissue]
Peptide AtlasQ9UBD5
HPRD05398
IPIIPI00294402   IPI00374747   IPI00908798   IPI00910327   IPI00983590   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBD5
IntAct (EBI)Q9UBD5
FunCoupENSG00000135336
BioGRIDORC3
STRING (EMBL)ORC3
ZODIACORC3
Ontologies - Pathways
QuickGOQ9UBD5
Ontology : AmiGOG1/S transition of mitotic cell cycle  nuclear chromosome, telomeric region  origin recognition complex  DNA replication origin binding  DNA replication origin binding  protein binding  nucleoplasm  nucleoplasm  nuclear pre-replicative complex  nuclear origin of replication recognition complex  nuclear origin of replication recognition complex  DNA replication  pre-replicative complex assembly involved in nuclear cell cycle DNA replication  DNA replication initiation  nuclear body  DNA replication preinitiation complex  neural precursor cell proliferation  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  nuclear chromosome, telomeric region  origin recognition complex  DNA replication origin binding  DNA replication origin binding  protein binding  nucleoplasm  nucleoplasm  nuclear pre-replicative complex  nuclear origin of replication recognition complex  nuclear origin of replication recognition complex  DNA replication  pre-replicative complex assembly involved in nuclear cell cycle DNA replication  DNA replication initiation  nuclear body  DNA replication preinitiation complex  neural precursor cell proliferation  
Pathways : KEGGCell cycle   
NDEx NetworkORC3
Atlas of Cancer Signalling NetworkORC3
Wikipedia pathwaysORC3
Orthology - Evolution
OrthoDB23595
GeneTree (enSembl)ENSG00000135336
Phylogenetic Trees/Animal Genes : TreeFamORC3
HOVERGENQ9UBD5
HOGENOMQ9UBD5
Homologs : HomoloGeneORC3
Homology/Alignments : Family Browser (UCSC)ORC3
Gene fusions - Rearrangements
Fusion : QuiverORC3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerORC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ORC3
dbVarORC3
ClinVarORC3
1000_GenomesORC3 
Exome Variant ServerORC3
ExAC (Exome Aggregation Consortium)ENSG00000135336
GNOMAD BrowserENSG00000135336
Varsome BrowserORC3
Genetic variants : HAPMAP23595
Genomic Variants (DGV)ORC3 [DGVbeta]
DECIPHERORC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisORC3 
Mutations
ICGC Data PortalORC3 
TCGA Data PortalORC3 
Broad Tumor PortalORC3
OASIS PortalORC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICORC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDORC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ORC3
DgiDB (Drug Gene Interaction Database)ORC3
DoCM (Curated mutations)ORC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ORC3 (select a term)
intoGenORC3
Cancer3DORC3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604972   
Orphanet
DisGeNETORC3
MedgenORC3
Genetic Testing Registry ORC3
NextProtQ9UBD5 [Medical]
TSGene23595
GENETestsORC3
Target ValidationORC3
Huge Navigator ORC3 [HugePedia]
snp3D : Map Gene to Disease23595
BioCentury BCIQORC3
ClinGenORC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23595
Chemical/Pharm GKB GenePA32810
Clinical trialORC3
Miscellaneous
canSAR (ICR)ORC3 (select the gene name)
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineORC3
EVEXORC3
GoPubMedORC3
iHOPORC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:42:13 CEST 2018

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