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ORC5 (origin recognition complex subunit 5)

Identity

Alias_namesregulatory subunit 117
ORC5L
Alias_symbol (synonym)Orc5p
ORC5T
PPP1R117
Other aliasORC5P
HGNC (Hugo) ORC5
LocusID (NCBI) 5001
Atlas_Id 43389
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 103766788 and ends at 103848495 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ORC5 (7q22.1) / PREB (2p23.3)ORC5 (7q22.1) / SHC3 (9q22.1)PRKAG2 (7q36.1) / ORC5 (7q22.1)
PRKAG2 7q36.1 / ORC5 7q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ORC5   8491
Cards
Entrez_Gene (NCBI)ORC5  5001  origin recognition complex subunit 5
AliasesORC5L; ORC5P; ORC5T; PPP1R117
GeneCards (Weizmann)ORC5
Ensembl hg19 (Hinxton)ENSG00000164815 [Gene_View]  chr7:103766788-103848495 [Contig_View]  ORC5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164815 [Gene_View]  chr7:103766788-103848495 [Contig_View]  ORC5 [Vega]
ICGC DataPortalENSG00000164815
TCGA cBioPortalORC5
AceView (NCBI)ORC5
Genatlas (Paris)ORC5
WikiGenes5001
SOURCE (Princeton)ORC5
Genetics Home Reference (NIH)ORC5
Genomic and cartography
GoldenPath hg19 (UCSC)ORC5  -     chr7:103766788-103848495 -  7q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ORC5  -     7q22.1   [Description]    (hg38-Dec_2013)
EnsemblORC5 - 7q22.1 [CytoView hg19]  ORC5 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBIORC5 [Mapview hg19]  ORC5 [Mapview hg38]
OMIM602331   
Gene and transcription
Genbank (Entrez)AF047599 AF049127 AF081459 AK223361 AK292285
RefSeq transcript (Entrez)NM_001197292 NM_002553 NM_181747
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_029899 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)ORC5
Cluster EST : UnigeneHs.432948 [ NCBI ]
CGAP (NCI)Hs.432948
Alternative Splicing GalleryENSG00000164815
Gene ExpressionORC5 [ NCBI-GEO ]   ORC5 [ EBI - ARRAY_EXPRESS ]   ORC5 [ SEEK ]   ORC5 [ MEM ]
Gene Expression Viewer (FireBrowse)ORC5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5001
GTEX Portal (Tissue expression)ORC5
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43913   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43913  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43913
Splice isoforms : SwissVarO43913
PhosPhoSitePlusO43913
Domains : Interpro (EBI)ORC5    P-loop_NTPase   
Domain families : Pfam (Sanger)ORC5_C (PF14630)   
Domain families : Pfam (NCBI)pfam14630   
Conserved Domain (NCBI)ORC5
DMDM Disease mutations5001
Blocks (Seattle)ORC5
SuperfamilyO43913
Human Protein AtlasENSG00000164815
Peptide AtlasO43913
HPRD09086
IPIIPI00015143   IPI01013160   IPI00927862   IPI00409636   
Protein Interaction databases
DIP (DOE-UCLA)O43913
IntAct (EBI)O43913
FunCoupENSG00000164815
BioGRIDORC5
STRING (EMBL)ORC5
ZODIACORC5
Ontologies - Pathways
QuickGOO43913
Ontology : AmiGOG1/S transition of mitotic cell cycle  nucleotide binding  nuclear chromosome, telomeric region  origin recognition complex  molecular_function  DNA replication origin binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nuclear origin of replication recognition complex  nuclear origin of replication recognition complex  cytoplasm  DNA replication  DNA replication  DNA replication initiation  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  nucleotide binding  nuclear chromosome, telomeric region  origin recognition complex  molecular_function  DNA replication origin binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nuclear origin of replication recognition complex  nuclear origin of replication recognition complex  cytoplasm  DNA replication  DNA replication  DNA replication initiation  
Pathways : BIOCARTACDK Regulation of DNA Replication [Genes]   
Pathways : KEGGCell cycle   
NDEx NetworkORC5
Atlas of Cancer Signalling NetworkORC5
Wikipedia pathwaysORC5
Orthology - Evolution
OrthoDB5001
GeneTree (enSembl)ENSG00000164815
Phylogenetic Trees/Animal Genes : TreeFamORC5
HOVERGENO43913
HOGENOMO43913
Homologs : HomoloGeneORC5
Homology/Alignments : Family Browser (UCSC)ORC5
Gene fusions - Rearrangements
Fusion : MitelmanPRKAG2/ORC5 [7q36.1/7q22.1]  [t(7;7)(q22;q36)]  
Fusion: TCGAPRKAG2 7q36.1 ORC5 7q22.1 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerORC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ORC5
dbVarORC5
ClinVarORC5
1000_GenomesORC5 
Exome Variant ServerORC5
ExAC (Exome Aggregation Consortium)ORC5 (select the gene name)
Genetic variants : HAPMAP5001
Genomic Variants (DGV)ORC5 [DGVbeta]
DECIPHER (Syndromes)7:103766788-103848495  ENSG00000164815
CONAN: Copy Number AnalysisORC5 
Mutations
ICGC Data PortalORC5 
TCGA Data PortalORC5 
Broad Tumor PortalORC5
OASIS PortalORC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICORC5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDORC5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ORC5
DgiDB (Drug Gene Interaction Database)ORC5
DoCM (Curated mutations)ORC5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ORC5 (select a term)
intoGenORC5
Cancer3DORC5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602331   
Orphanet
MedgenORC5
Genetic Testing Registry ORC5
NextProtO43913 [Medical]
TSGene5001
GENETestsORC5
Huge Navigator ORC5 [HugePedia]
snp3D : Map Gene to Disease5001
BioCentury BCIQORC5
ClinGenORC5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5001
Chemical/Pharm GKB GenePA32812
Clinical trialORC5
Miscellaneous
canSAR (ICR)ORC5 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineORC5
EVEXORC5
GoPubMedORC5
iHOPORC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:19:55 CET 2017

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