ORC6 (origin recognition complex subunit 6)

2010-10-01  

Identity

HGNC
LOCATION
16q11.2
LOCUSID
ALIAS
ORC6L
FUSION GENES

Other Information

Locus ID:

NCBI: 23594
MIM: 607213
HGNC: 17151
Ensembl: ENSG00000091651

Variants:

dbSNP: 23594
ClinVar: 23594
TCGA: ENSG00000091651
COSMIC: ORC6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000091651ENST00000219097Q9Y5N6
ENSG00000091651ENST00000219097A0A024R6R3
ENSG00000091651ENST00000563599H3BMA4
ENSG00000091651ENST00000566860H3BT22
ENSG00000091651ENST00000568364H3BTQ7

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Origin recognition complexKEGGhsa_M00284
Origin recognition complexKEGGM00284
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
Activation of ATR in response to replication stressREACTOMER-HSA-176187
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Activation of the pre-replicative complexREACTOMER-HSA-68962
E2F mediated regulation of DNA replicationREACTOMER-HSA-113510
E2F-enabled inhibition of pre-replication complex formationREACTOMER-HSA-113507
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
Switching of origins to a post-replicative stateREACTOMER-HSA-69052
Orc1 removal from chromatinREACTOMER-HSA-68949
Regulation of DNA replicationREACTOMER-HSA-69304
Removal of licensing factors from originsREACTOMER-HSA-69300
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
Assembly of the pre-replicative complexREACTOMER-HSA-68867
Assembly of the ORC complex at the origin of replicationREACTOMER-HSA-68616
CDC6 association with the ORC:origin complexREACTOMER-HSA-68689
CDT1 association with the CDC6:ORC:origin complexREACTOMER-HSA-68827
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
82660751993Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system.134
121697362002Orc6 involved in DNA replication, chromosome segregation, and cytokinesis.80
115930092001Functional analysis of mutant and wild-type Drosophila origin recognition complex.46
215025372011Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB.24
241375362013A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation.21
159100032005Ku80 binds to human replication origins prior to the assembly of the ORC complex.16
195416342009Functional analysis of an Orc6 mutant in Drosophila.16
191125052008Reduction of Orc6 expression sensitizes human colon cancer cells to 5-fluorouracil and cisplatin.9
214617832011Different roles of the human Orc6 protein in the replication initiation process.6
256914132015Further insight into the phenotype associated with a mutation in the ORC6 gene, causing Meier-Gorlin syndrome 3.4

Citation

Dessen P

ORC6 (origin recognition complex subunit 6)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51742/orc6