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OSBP (oxysterol binding protein)

Identity

Alias (NCBI)OSBP1
HGNC (Hugo) OSBP
HGNC Alias symbOSBP1
LocusID (NCBI) 5007
Atlas_Id 47320
Location 11q12.1  [Link to chromosome band 11q12]
Location_base_pair Starts at 59574398 and ends at 59615774 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DOCK8 (9p24.3) / OSBP (11q12.1)OSBP (11q12.1) / GAL (11q13.3)OSBP (11q12.1) / SRRM1 (1p36.11)
DOCK8 9p24.3 / OSBP 11q12.1OSBP 11q12.1 / GAL 11q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)OSBP   8503
Cards
Entrez_Gene (NCBI)OSBP    oxysterol binding protein
AliasesOSBP1
GeneCards (Weizmann)OSBP
Ensembl hg19 (Hinxton)ENSG00000110048 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110048 [Gene_View]  ENSG00000110048 [Sequence]  chr11:59574398-59615774 [Contig_View]  OSBP [Vega]
ICGC DataPortalENSG00000110048
TCGA cBioPortalOSBP
AceView (NCBI)OSBP
Genatlas (Paris)OSBP
SOURCE (Princeton)OSBP
Genetics Home Reference (NIH)OSBP
Genomic and cartography
GoldenPath hg38 (UCSC)OSBP  -     chr11:59574398-59615774 -  11q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OSBP  -     11q12.1   [Description]    (hg19-Feb_2009)
GoldenPathOSBP - 11q12.1 [CytoView hg19]  OSBP - 11q12.1 [CytoView hg38]
ImmunoBaseENSG00000110048
Genome Data Viewer NCBIOSBP [Mapview hg19]  
OMIM167040   
Gene and transcription
Genbank (Entrez)AF185696 AK299071 AK310538 BC011581 BC017975
RefSeq transcript (Entrez)NM_002556
Consensus coding sequences : CCDS (NCBI)OSBP
Gene ExpressionOSBP [ NCBI-GEO ]   OSBP [ EBI - ARRAY_EXPRESS ]   OSBP [ SEEK ]   OSBP [ MEM ]
Gene Expression Viewer (FireBrowse)OSBP [ Firebrowse - Broad ]
GenevisibleExpression of OSBP in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5007
GTEX Portal (Tissue expression)OSBP
Human Protein AtlasENSG00000110048-OSBP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22059   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP22059  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22059
PhosPhoSitePlusP22059
Domaine pattern : Prosite (Expaxy)OSBP (PS01013)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)OSBP_sf    Oxysterol-bd    Oxysterol-bd_CS    PH-like_dom_sf    PH_domain   
Domain families : Pfam (Sanger)Oxysterol_BP (PF01237)    PH (PF00169)   
Domain families : Pfam (NCBI)pfam01237    pfam00169   
Domain families : Smart (EMBL)PH (SM00233)  
Conserved Domain (NCBI)OSBP
PDB (RSDB)2RR3   
PDB Europe2RR3   
PDB (PDBSum)2RR3   
PDB (IMB)2RR3   
Structural Biology KnowledgeBase2RR3   
SCOP (Structural Classification of Proteins)2RR3   
CATH (Classification of proteins structures)2RR3   
SuperfamilyP22059
AlphaFold pdb e-kbP22059   
Human Protein Atlas [tissue]ENSG00000110048-OSBP [tissue]
HPRD01327
Protein Interaction databases
DIP (DOE-UCLA)P22059
IntAct (EBI)P22059
BioGRIDOSBP
STRING (EMBL)OSBP
ZODIACOSBP
Ontologies - Pathways
QuickGOP22059
Ontology : AmiGOGolgi membrane  protein binding  nucleoplasm  nucleolus  cytoplasm  endoplasmic reticulum membrane  Golgi apparatus  trans-Golgi network  cytosol  cytosol  cytosol  plasma membrane  bile acid biosynthetic process  oxysterol binding  sterol transporter activity  sterol transport  membrane  membrane  protein domain specific binding  cell junction  intracellular cholesterol transport  sterol binding  positive regulation of insulin secretion involved in cellular response to glucose stimulus  positive regulation of tyrosine phosphorylation of STAT protein  intracellular membrane-bounded organelle  perinuclear region of cytoplasm  phosphatidylinositol-4-phosphate binding  perinuclear endoplasmic reticulum  intermembrane lipid transfer  sterol transfer activity  positive regulation of secretory granule organization  
Ontology : EGO-EBIGolgi membrane  protein binding  nucleoplasm  nucleolus  cytoplasm  endoplasmic reticulum membrane  Golgi apparatus  trans-Golgi network  cytosol  cytosol  cytosol  plasma membrane  bile acid biosynthetic process  oxysterol binding  sterol transporter activity  sterol transport  membrane  membrane  protein domain specific binding  cell junction  intracellular cholesterol transport  sterol binding  positive regulation of insulin secretion involved in cellular response to glucose stimulus  positive regulation of tyrosine phosphorylation of STAT protein  intracellular membrane-bounded organelle  perinuclear region of cytoplasm  phosphatidylinositol-4-phosphate binding  perinuclear endoplasmic reticulum  intermembrane lipid transfer  sterol transfer activity  positive regulation of secretory granule organization  
NDEx NetworkOSBP
Atlas of Cancer Signalling NetworkOSBP
Wikipedia pathwaysOSBP
Orthology - Evolution
OrthoDB5007
GeneTree (enSembl)ENSG00000110048
Phylogenetic Trees/Animal Genes : TreeFamOSBP
Homologs : HomoloGeneOSBP
Homology/Alignments : Family Browser (UCSC)OSBP
Gene fusions - Rearrangements
Fusion : MitelmanDOCK8/OSBP [9p24.3/11q12.1]  
Fusion : MitelmanOSBP/GAL [11q12.1/11q13.3]  
Fusion : QuiverOSBP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOSBP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OSBP
dbVarOSBP
ClinVarOSBP
MonarchOSBP
1000_GenomesOSBP 
Exome Variant ServerOSBP
GNOMAD BrowserENSG00000110048
Varsome BrowserOSBP
ACMGOSBP variants
VarityP22059
Genomic Variants (DGV)OSBP [DGVbeta]
DECIPHEROSBP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOSBP 
Mutations
ICGC Data PortalOSBP 
TCGA Data PortalOSBP 
Broad Tumor PortalOSBP
OASIS PortalOSBP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOSBP  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DOSBP
Mutations and Diseases : HGMDOSBP
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaOSBP
DgiDB (Drug Gene Interaction Database)OSBP
DoCM (Curated mutations)OSBP
CIViC (Clinical Interpretations of Variants in Cancer)OSBP
Cancer3DOSBP
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM167040   
Orphanet
DisGeNETOSBP
MedgenOSBP
Genetic Testing Registry OSBP
NextProtP22059 [Medical]
GENETestsOSBP
Target ValidationOSBP
Huge Navigator OSBP [HugePedia]
ClinGenOSBP
Clinical trials, drugs, therapy
MyCancerGenomeOSBP
Protein Interactions : CTDOSBP
Pharm GKB GenePA32822
PharosP22059
Clinical trialOSBP
Miscellaneous
canSAR (ICR)OSBP
HarmonizomeOSBP
DataMed IndexOSBP
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXOSBP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:23:53 CEST 2021

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