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OSBPL2 (oxysterol binding protein like 2)

Identity

Alias (NCBI)DFNA67
DNFA67
ORP-2
ORP2
HGNC (Hugo) OSBPL2
HGNC Alias symbKIAA0772
ORP-2
DFNA67
HGNC Previous nameoxysterol-binding protein-like 2
 oxysterol binding protein-like 2
LocusID (NCBI) 9885
Atlas_Id 57733
Location 20q13.33  [Link to chromosome band 20q13]
Location_base_pair Starts at 62238521 and ends at 62296183 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
OSBPL2 (20q13.33) / CDH4 (20q13.33)OSBPL2 (20q13.33) / CELSR1 (22q13.31)OSBPL2 (20q13.33) / DLGAP4 (20q11.23)
OSBPL2 (20q13.33) / OSBPL2 (20q13.33)OSBPL2 (20q13.33) / PLD1 (3q26.31)TTC31 (2p13.1) / OSBPL2 (20q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)OSBPL2   15761
Cards
Entrez_Gene (NCBI)OSBPL2    oxysterol binding protein like 2
AliasesDFNA67; DNFA67; ORP-2; ORP2
GeneCards (Weizmann)OSBPL2
Ensembl hg19 (Hinxton)ENSG00000130703 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130703 [Gene_View]  ENSG00000130703 [Sequence]  chr20:62238521-62296183 [Contig_View]  OSBPL2 [Vega]
ICGC DataPortalENSG00000130703
TCGA cBioPortalOSBPL2
AceView (NCBI)OSBPL2
Genatlas (Paris)OSBPL2
SOURCE (Princeton)OSBPL2
Genetics Home Reference (NIH)OSBPL2
Genomic and cartography
GoldenPath hg38 (UCSC)OSBPL2  -     chr20:62238521-62296183 +  20q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OSBPL2  -     20q13.33   [Description]    (hg19-Feb_2009)
GoldenPathOSBPL2 - 20q13.33 [CytoView hg19]  OSBPL2 - 20q13.33 [CytoView hg38]
ImmunoBaseENSG00000130703
Genome Data Viewer NCBIOSBPL2 [Mapview hg19]  
OMIM606731   616340   
Gene and transcription
Genbank (Entrez)AB018315 AF331963 AF392447 AK000230 AK093592
RefSeq transcript (Entrez)NM_001001691 NM_001278649 NM_001363878 NM_014835 NM_144498
Consensus coding sequences : CCDS (NCBI)OSBPL2
Gene ExpressionOSBPL2 [ NCBI-GEO ]   OSBPL2 [ EBI - ARRAY_EXPRESS ]   OSBPL2 [ SEEK ]   OSBPL2 [ MEM ]
Gene Expression Viewer (FireBrowse)OSBPL2 [ Firebrowse - Broad ]
GenevisibleExpression of OSBPL2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9885
GTEX Portal (Tissue expression)OSBPL2
Human Protein AtlasENSG00000130703-OSBPL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H1P3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H1P3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H1P3
PhosPhoSitePlusQ9H1P3
Domaine pattern : Prosite (Expaxy)OSBP (PS01013)   
Domains : Interpro (EBI)OSBP_sf    Oxysterol-bd    Oxysterol-bd_CS   
Domain families : Pfam (Sanger)Oxysterol_BP (PF01237)   
Domain families : Pfam (NCBI)pfam01237   
Conserved Domain (NCBI)OSBPL2
PDB (RSDB)5ZM8   
PDB Europe5ZM8   
PDB (PDBSum)5ZM8   
PDB (IMB)5ZM8   
Structural Biology KnowledgeBase5ZM8   
SCOP (Structural Classification of Proteins)5ZM8   
CATH (Classification of proteins structures)5ZM8   
SuperfamilyQ9H1P3
AlphaFold pdb e-kbQ9H1P3   
Human Protein Atlas [tissue]ENSG00000130703-OSBPL2 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9H1P3
IntAct (EBI)Q9H1P3
BioGRIDOSBPL2
STRING (EMBL)OSBPL2
ZODIACOSBPL2
Ontologies - Pathways
QuickGOQ9H1P3
Ontology : AmiGOprotein binding  phosphatidylinositol-4,5-bisphosphate binding  lipid droplet  cytosol  cytosol  cytosol  bile acid biosynthetic process  plasma membrane organization  phosphatidylinositol transfer activity  sterol transporter activity  cholesterol binding  cholesterol binding  phospholipid transport  membrane  cholesterol transport  extrinsic component of cytoplasmic side of plasma membrane  intracellular cholesterol transport  sterol binding  intracellular membrane-bounded organelle  protein homotetramerization  intermembrane lipid transfer  cholesterol transfer activity  
Ontology : EGO-EBIprotein binding  phosphatidylinositol-4,5-bisphosphate binding  lipid droplet  cytosol  cytosol  cytosol  bile acid biosynthetic process  plasma membrane organization  phosphatidylinositol transfer activity  sterol transporter activity  cholesterol binding  cholesterol binding  phospholipid transport  membrane  cholesterol transport  extrinsic component of cytoplasmic side of plasma membrane  intracellular cholesterol transport  sterol binding  intracellular membrane-bounded organelle  protein homotetramerization  intermembrane lipid transfer  cholesterol transfer activity  
NDEx NetworkOSBPL2
Atlas of Cancer Signalling NetworkOSBPL2
Wikipedia pathwaysOSBPL2
Orthology - Evolution
OrthoDB9885
GeneTree (enSembl)ENSG00000130703
Phylogenetic Trees/Animal Genes : TreeFamOSBPL2
Homologs : HomoloGeneOSBPL2
Homology/Alignments : Family Browser (UCSC)OSBPL2
Gene fusions - Rearrangements
Fusion : QuiverOSBPL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOSBPL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OSBPL2
dbVarOSBPL2
ClinVarOSBPL2
MonarchOSBPL2
1000_GenomesOSBPL2 
Exome Variant ServerOSBPL2
GNOMAD BrowserENSG00000130703
Varsome BrowserOSBPL2
ACMGOSBPL2 variants
VarityQ9H1P3
Genomic Variants (DGV)OSBPL2 [DGVbeta]
DECIPHEROSBPL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOSBPL2 
Mutations
ICGC Data PortalOSBPL2 
TCGA Data PortalOSBPL2 
Broad Tumor PortalOSBPL2
OASIS PortalOSBPL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOSBPL2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DOSBPL2
Mutations and Diseases : HGMDOSBPL2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaOSBPL2
DgiDB (Drug Gene Interaction Database)OSBPL2
DoCM (Curated mutations)OSBPL2
CIViC (Clinical Interpretations of Variants in Cancer)OSBPL2
Cancer3DOSBPL2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606731    616340   
Orphanet
DisGeNETOSBPL2
MedgenOSBPL2
Genetic Testing Registry OSBPL2
NextProtQ9H1P3 [Medical]
GENETestsOSBPL2
Target ValidationOSBPL2
Huge Navigator OSBPL2 [HugePedia]
ClinGenOSBPL2
Clinical trials, drugs, therapy
MyCancerGenomeOSBPL2
Protein Interactions : CTDOSBPL2
Pharm GKB GenePA32827
PharosQ9H1P3
Clinical trialOSBPL2
Miscellaneous
canSAR (ICR)OSBPL2
HarmonizomeOSBPL2
DataMed IndexOSBPL2
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXOSBPL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:23:54 CEST 2021

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